A validated finite element model to reproduce Helmholtz’s theory of accommodation: a powerful tool to investigate presbyopia
Cabeza-Gil, Iulen (Universidad de Zaragoza) ; Grasa, Jorge (Universidad de Zaragoza) ; Calvo, Begoña (Universidad de Zaragoza)
Resumen: Purpose
To reproduce human in vivo accommodation numerically. For that purpose, a finite element model specific for a 29-year-old subject was designed. Once the proposed numerical model was validated, the decrease in accommodative amplitude with age was simulated according to data available in the literature.
Methods
In contrast with previous studies, the non-accommodated eye condition was the reference configuration. Consequently, two aspects were specifically highlighted: contraction of the ciliary muscle, which was simulated by a continuum electro-mechanical model and incorporation of initial lens capsule stresses, which allowed the lens to become accommodated after releasing the resting zonular tension.
Results
The morphological changes and contraction of the ciliary muscle were calibrated accurately according to the experimental data from the literature. All dynamic optical and biometric lens measurements validated the model. With the proposed numerical model, presbyopia was successfully simulated.
Conclusions
The most widespread theory of accommodation, proposed by Helmholtz, was simulated accurately. Assuming the same initial stresses in the lens capsule over time, stiffening of the lens nucleus is the main cause of presbyopia.
Idioma: Inglés
DOI: 10.1111/opo.12876
Año: 2021
Publicado en: OPHTHALMIC AND PHYSIOLOGICAL OPTICS 41, 6 (2021), 1241-1253
ISSN: 0275-5408
Factor impacto JCR: 3.992 (2021)
Categ. JCR: OPHTHALMOLOGY rank: 17 / 62 = 0.274 (2021) - Q2 - T1
Factor impacto CITESCORE: 4.1 - Health Professions (Q1) - Medicine (Q2) - Neuroscience (Q3)
Factor impacto SCIMAGO: 1.051 - Optometry (Q1) - Ophthalmology (Q1)
Financiación: info:eu-repo/grantAgreement/ES/MCIU/DPI2017-84047-R
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace.
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To reproduce human in vivo accommodation numerically. For that purpose, a finite element model specific for a 29-year-old subject was designed. Once the proposed numerical model was validated, the decrease in accommodative amplitude with age was simulated according to data available in the literature.
Methods
In contrast with previous studies, the non-accommodated eye condition was the reference configuration. Consequently, two aspects were specifically highlighted: contraction of the ciliary muscle, which was simulated by a continuum electro-mechanical model and incorporation of initial lens capsule stresses, which allowed the lens to become accommodated after releasing the resting zonular tension.
Results
The morphological changes and contraction of the ciliary muscle were calibrated accurately according to the experimental data from the literature. All dynamic optical and biometric lens measurements validated the model. With the proposed numerical model, presbyopia was successfully simulated.
Conclusions
The most widespread theory of accommodation, proposed by Helmholtz, was simulated accurately. Assuming the same initial stresses in the lens capsule over time, stiffening of the lens nucleus is the main cause of presbyopia.
Idioma: Inglés
DOI: 10.1111/opo.12876
Año: 2021
Publicado en: OPHTHALMIC AND PHYSIOLOGICAL OPTICS 41, 6 (2021), 1241-1253
ISSN: 0275-5408
Factor impacto JCR: 3.992 (2021)
Categ. JCR: OPHTHALMOLOGY rank: 17 / 62 = 0.274 (2021) - Q2 - T1
Factor impacto CITESCORE: 4.1 - Health Professions (Q1) - Medicine (Q2) - Neuroscience (Q3)
Factor impacto SCIMAGO: 1.051 - Optometry (Q1) - Ophthalmology (Q1)
Financiación: info:eu-repo/grantAgreement/ES/MCIU/DPI2017-84047-R
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. Exportado de SIDERAL (2023-12-15-09:00:03)
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Registro creado el 2021-12-16, última modificación el 2023-12-15