A validated finite element model to reproduce Helmholtz’s theory of accommodation: a powerful tool to investigate presbyopia
Resumen: Purpose
To reproduce human in vivo accommodation numerically. For that purpose, a finite element model specific for a 29-year-old subject was designed. Once the proposed numerical model was validated, the decrease in accommodative amplitude with age was simulated according to data available in the literature.

Methods
In contrast with previous studies, the non-accommodated eye condition was the reference configuration. Consequently, two aspects were specifically highlighted: contraction of the ciliary muscle, which was simulated by a continuum electro-mechanical model and incorporation of initial lens capsule stresses, which allowed the lens to become accommodated after releasing the resting zonular tension.

Results
The morphological changes and contraction of the ciliary muscle were calibrated accurately according to the experimental data from the literature. All dynamic optical and biometric lens measurements validated the model. With the proposed numerical model, presbyopia was successfully simulated.

Conclusions
The most widespread theory of accommodation, proposed by Helmholtz, was simulated accurately. Assuming the same initial stresses in the lens capsule over time, stiffening of the lens nucleus is the main cause of presbyopia.

Idioma: Inglés
DOI: 10.1111/opo.12876
Año: 2021
Publicado en: OPHTHALMIC AND PHYSIOLOGICAL OPTICS 41, 6 (2021), 1241-1253
ISSN: 0275-5408

Factor impacto JCR: 3.992 (2021)
Categ. JCR: OPHTHALMOLOGY rank: 17 / 62 = 0.274 (2021) - Q2 - T1
Factor impacto CITESCORE: 4.1 - Health Professions (Q1) - Medicine (Q2) - Neuroscience (Q3)

Factor impacto SCIMAGO: 1.051 - Optometry (Q1) - Ophthalmology (Q1)

Financiación: info:eu-repo/grantAgreement/ES/MCIU/DPI2017-84047-R
Tipo y forma: Article (Published version)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)

Creative Commons You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.


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 Record created 2021-12-16, last modified 2023-12-15


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