000109071 001__ 109071 000109071 005__ 20231215090956.0 000109071 0247_ $$2doi$$a10.1038/s41598-021-89145-z 000109071 0248_ $$2sideral$$a125154 000109071 037__ $$aART-2021-125154 000109071 041__ $$aeng 000109071 100__ $$0(orcid)0000-0001-8219-2365$$aCabeza-Gil, I.$$uUniversidad de Zaragoza 000109071 245__ $$aA numerical investigation of changes in lens shape during accommodation 000109071 260__ $$c2021 000109071 5060_ $$aAccess copy available to the general public$$fUnrestricted 000109071 5203_ $$aThe purpose of this study was to investigate how the mechanical properties and geometry of the lens influence the changes in lens shape during accommodation. To do so, ex vivo stretching tests of the isolated lens were simulated via finite element analysis. In these tests, the lens is stretched from the accommodated state to the non-accommodated state. Several key characteristics of the lens were studied: the stiffness gradient of the lens material, the distribution of the capsule thickness, the mechanical properties of the capsule and the material comprising the lens, nucleus and cortex, and the influence of two different age-related lens geometries (17 and 29 y/o subjects). To determine the effects on the changes in lens shape during accommodation, changes in the anterior and posterior radius, the lens and nucleus thicknesses and the equatorial lens diameter were analysed. The results suggest that multiple factors exert statistically significant influences on how the lens changes its shape, but two factors predominate over the rest: the stiffness ratio between the nucleus and cortex and the stiffness of the capsule, specifically the posterior surface. 000109071 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/PRE2018-084021$$9info:eu-repo/grantAgreement/ES/MINECO/DPI2017-84047-R$$9info:eu-repo/grantAgreement/ES/DGA-FSE/T24-20R$$9info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-U27 Unit-CIBER-BBN 000109071 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000109071 590__ $$a4.997$$b2021 000109071 592__ $$a1.005$$b2021 000109071 591__ $$aMULTIDISCIPLINARY SCIENCES$$b19 / 74 = 0.257$$c2021$$dQ2$$eT1 000109071 593__ $$aMultidisciplinary$$c2021$$dQ1 000109071 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000109071 700__ $$0(orcid)0000-0002-6870-0594$$aGrasa, J.$$uUniversidad de Zaragoza 000109071 700__ $$0(orcid)0000-0001-9713-1813$$aCalvo, B.$$uUniversidad de Zaragoza 000109071 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est. 000109071 773__ $$g11 (2021), 9639 [12 pp.]$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322 000109071 8564_ $$s3842727$$uhttps://zaguan.unizar.es/record/109071/files/texto_completo.pdf$$yVersión publicada 000109071 8564_ $$s2569606$$uhttps://zaguan.unizar.es/record/109071/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000109071 909CO $$ooai:zaguan.unizar.es:109071$$particulos$$pdriver 000109071 951__ $$a2023-12-15-09:00:06 000109071 980__ $$aARTICLE