109071 20231215090956.0 doi 10.1038/s41598-021-89145-z sideral 125154 ART-2021-125154 eng Cabeza-Gil, I. Universidad de Zaragoza (orcid)0000-0001-8219-2365 A numerical investigation of changes in lens shape during accommodation 2021 Access copy available to the general public Unrestricted The purpose of this study was to investigate how the mechanical properties and geometry of the lens influence the changes in lens shape during accommodation. To do so, ex vivo stretching tests of the isolated lens were simulated via finite element analysis. In these tests, the lens is stretched from the accommodated state to the non-accommodated state. Several key characteristics of the lens were studied: the stiffness gradient of the lens material, the distribution of the capsule thickness, the mechanical properties of the capsule and the material comprising the lens, nucleus and cortex, and the influence of two different age-related lens geometries (17 and 29 y/o subjects). To determine the effects on the changes in lens shape during accommodation, changes in the anterior and posterior radius, the lens and nucleus thicknesses and the equatorial lens diameter were analysed. The results suggest that multiple factors exert statistically significant influences on how the lens changes its shape, but two factors predominate over the rest: the stiffness ratio between the nucleus and cortex and the stiffness of the capsule, specifically the posterior surface. info:eu-repo/grantAgreement/ES/DGA-FSE/T24-20R info:eu-repo/grantAgreement/ES/MINECO/DPI2017-84047-R info:eu-repo/grantAgreement/ES/MINECO/PRE2018-084021 info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-U27 Unit-CIBER-BBN info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.997 2021 MULTIDISCIPLINARY SCIENCES 19 / 74 = 0.257 2021 Q2 T1 1.005 2021 Multidisciplinary 2021 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Grasa, J. Universidad de Zaragoza (orcid)0000-0002-6870-0594 Calvo, B. Universidad de Zaragoza (orcid)0000-0001-9713-1813 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 11 (2021), 9639 [12 pp.] Sci. rep. (Nat. Publ. Group) Scientific reports (Nature Publishing Group) 2045-2322 3842727 http://zaguan.unizar.es/record/109071/files/texto_completo.pdf Versión publicada 2569606 http://zaguan.unizar.es/record/109071/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:109071 articulos driver 2023-12-15-09:00:06 ARTICLE