109092 20260202145620.0 doi 10.3390/antiox10111853 sideral 125454 ART-2021-125454 eng Fuentes-Broto, Lorena Universidad de Zaragoza (orcid)0000-0003-2656-6750 Effects of daily melatonin supplementation on visual loss, circadian rhythms, and hepatic oxidative damage in a rodent model of retinitis pigmentosa 2021 Access copy available to the general public Unrestricted Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases characterized by a progressive loss of visual function that primarily affect photoreceptors, resulting in the complete disorganization and remodeling of the retina. Progression of the disease is enhanced by increased oxidative stress in the retina, aqueous humor, plasma, and liver of RP animal models and patients. Melatonin has beneficial effects against age-related macular degeneration, glaucoma, and diabetic retinopathy, in which oxidative stress plays a key role. In the present study, we used the P23HxLE rat as an animal model of RP. Melatonin treatment (10 mgkg b.w. daily in drinking water for 6 months) improved the parameters of visual function and decreased the rate of desynchronization of the circadian rhythm, both in P23HxLE and wild-type rats. Melatonin reduced oxidative stress and increased antioxidant defenses in P23HxLE animals. In wild-type animals, melatonin did not modify any of the oxidative stress markers analyzed and reduced the levels of total antioxidant defenses. Treatment with melatonin improved visual function, circadian synchronization, and hepatic oxidative stress in P23HxLE rats, an RP model, and had beneficial effects against age-related visual damage in wild-type rats. info:eu-repo/grantAgreement/ES/DGA/B08-17R info:eu-repo/grantAgreement/ES/ISCIII/PI13-01124 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 7.675 2021 BIOCHEMISTRY & MOLECULAR BIOLOGY 50 / 297 = 0.168 2021 Q1 T1 FOOD SCIENCE & TECHNOLOGY 12 / 144 = 0.083 2021 Q1 T1 CHEMISTRY, MEDICINAL 4 / 63 = 0.063 2021 Q1 T1 1.008 2021 Biochemistry 2021 Q1 Physiology 2021 Q1 Molecular Biology 2021 Q1 Clinical Biochemistry 2021 Q1 6.5 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Perdices, Lorena Segura, Francisco Universidad de Zaragoza (orcid)0000-0002-9250-9060 Orduna-Hospital, Elvira Universidad de Zaragoza (orcid)0000-0003-2710-1875 Insa-Sánchez, Gema Universidad de Zaragoza (orcid)0000-0002-4836-7106 Sánchez-Cano, Ana I. Cuenca, Nicolás Pinilla, Isabel 1012 410 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Fisiología 1013 646 Universidad de Zaragoza Dpto. Cirugía Área Oftalmología 2002 647 Universidad de Zaragoza Dpto. Física Aplicada Área Óptica 10, 11 (2021), 1853 [16 pp] Antioxidants Antioxidants 2076-3921 1790542 http://zaguan.unizar.es/record/109092/files/texto_completo.pdf Versión publicada 2708211 http://zaguan.unizar.es/record/109092/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:109092 articulos driver 2026-02-02-14:49:03 ARTICLE