000109103 001__ 109103
000109103 005__ 20231215090957.0
000109103 0247_ $$2doi$$a10.1002/jsfa.11017
000109103 0248_ $$2sideral$$a122446
000109103 037__ $$aART-2021-122446
000109103 041__ $$aeng
000109103 100__ $$aLópez-Miranda, S.
000109103 245__ $$aModified cyclodextrin type and dehydration methods exert a significant effect on the antimicrobial activity of encapsulated carvacrol and thymol
000109103 260__ $$c2021
000109103 5060_ $$aAccess copy available to the general public$$fUnrestricted
000109103 5203_ $$aBACKGROUND
The antimicrobial activity of essential oils and their constituents has led to increasing interest in using them as natural preservative agents. However, their high sensitivity to light and oxygen, their volatility and their low aqueous solubility are all obstacles to their application in the food, cosmetic or pharmaceutical industries. Encapsulation in cyclodextrins (CDs) is a solution for the application of such essential oils.
RESULTS
The complexation of carvacrol and thymol with hydroxypropyl (HP)‐α‐, HP‐β‐ and HP‐γ‐CD, the behavior of the solid complexes prepared by freeze‐drying and spray‐drying methods and the antibacterial activity of solid complexes were studied. Kc values of HP‐α‐ and HP‐γ‐CD complexes with carvacrol (118.4 and 365.7 L mol−1) and thymol (112.5 and 239.7 L mol −1) were far lower than those observed for HP‐β‐CD complexes with carvacrol (2268.2 L mol −1) and thymol (881.6 L mol −1). The lower stability of HP‐α‐ and HP‐γ‐CD complexes increased the release of compounds, thereby affecting the antimicrobial activity of carvacrol and thymol to a lesser extent than complexation with HP‐β‐CD, normally used in the encapsulation of carvacrol and thymol. HP‐β‐CD encapsulation of carvacrol and thymol markedly reduced their antimicrobial activity. The freeze‐drying method barely affected the antimicrobial activity of carvacrol and thymol after encapsulation, while spray drying could be considered for the production of solid complexes in combination with the appropriate CD.
CONCLUSIONS
It was thus demonstrated that HP‐α‐ and HP‐γ‐CD are very suitable alternatives for the encapsulation of carvacrol and thymol with the purpose of preserving their bacteriostatic and bactericidal activities.
000109103 536__ $$9info:eu-repo/grantAgreement/ES/DGA/FSE$$9info:eu-repo/grantAgreement/ES/MINECO/PGC2018-093789-B-I00
000109103 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000109103 590__ $$a4.125$$b2021
000109103 592__ $$a0.705$$b2021
000109103 594__ $$a6.9$$b2021
000109103 591__ $$aAGRICULTURE, MULTIDISCIPLINARY$$b12 / 59 = 0.203$$c2021$$dQ1$$eT1
000109103 593__ $$aAgronomy and Crop Science$$c2021$$dQ1
000109103 591__ $$aCHEMISTRY, APPLIED$$b21 / 72 = 0.292$$c2021$$dQ2$$eT1
000109103 593__ $$aNutrition and Dietetics$$c2021$$dQ1
000109103 591__ $$aFOOD SCIENCE & TECHNOLOGY$$b49 / 144 = 0.34$$c2021$$dQ2$$eT2
000109103 593__ $$aFood Science$$c2021$$dQ1
000109103 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/submittedVersion
000109103 700__ $$0(orcid)0000-0001-5053-8309$$aBerdejo, D.$$uUniversidad de Zaragoza
000109103 700__ $$0(orcid)0000-0003-3752-4660$$aPagán, E.$$uUniversidad de Zaragoza
000109103 700__ $$0(orcid)0000-0002-7629-8101$$aGarcía-Gonzalo, D.$$uUniversidad de Zaragoza
000109103 700__ $$0(orcid)0000-0002-0238-6328$$aPagán, R.$$uUniversidad de Zaragoza
000109103 7102_ $$12008$$2780$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Tecnología de Alimentos
000109103 773__ $$g101, 9 (2021), 3827-3835$$pJ. Sci. Food Agric.$$tJournal of the science of food and agriculture$$x0022-5142
000109103 8564_ $$s449480$$uhttps://zaguan.unizar.es/record/109103/files/texto_completo.pdf$$yPreprint
000109103 8564_ $$s1390959$$uhttps://zaguan.unizar.es/record/109103/files/texto_completo.jpg?subformat=icon$$xicon$$yPreprint
000109103 909CO $$ooai:zaguan.unizar.es:109103$$particulos$$pdriver
000109103 951__ $$a2023-12-15-09:01:13
000109103 980__ $$aARTICLE