000109104 001__ 109104 000109104 005__ 20230519145518.0 000109104 0247_ $$2doi$$a10.1002/anie.202013563 000109104 0248_ $$2sideral$$a122246 000109104 037__ $$aART-2021-122246 000109104 041__ $$aeng 000109104 100__ $$0(orcid)0000-0002-5823-0314$$aSoria-Carrera, H. 000109104 245__ $$aOn-POM Ring-Opening Polymerisation of N-Carboxyanhydrides 000109104 260__ $$c2021 000109104 5060_ $$aAccess copy available to the general public$$fUnrestricted 000109104 5203_ $$aThe ring-opening polymerisation of a-amino acid N-carboxyanhydrides (NCAs) offers a simple and scalable route to polypeptides with predicted and narrow molecular weight distributions. Here we show how polyoxometalates (POMs)-redox-active molecular metal-oxide anions-can serve as inorganic scaffold initiators for such NCA polymerisations. This "On-POM polymerisation" strategy serves as an innovative platform to design hybrid materials with additive or synergistic properties stemming from the inorganic and polypeptide component parts. We have used this synthetic approach to synthesise a library of bactericidal poly(lysine)-POM hybrid derivatives that can be used to prevent biofilm formation. This versatile "On-POM polymerisation" method provides a flexible synthetic approach for combining inorganic scaffolds with amino acids, and the potential to tailor and improve the specificity and performance of hybrid antimicrobial materials. 000109104 536__ $$9info:eu-repo/grantAgreement/ES/CSIC/i-Link+2019-LINK20270$$9info:eu-repo/grantAgreement/ES/DGA-FSE/CIBER-BBN$$9info:eu-repo/grantAgreement/ES/DGA-FSE/E15-20R$$9info:eu-repo/grantAgreement/ES/DGA-FSE/E31-17R$$9info:eu-repo/grantAgreement/ES/DGA-FSE/E47-20R$$9info:eu-repo/grantAgreement/ES/MCIU/PGC2018-097583-B-I00$$9info:eu-repo/grantAgreement/ES/MCIU/PID2019-105881RB-I00$$9info:eu-repo/grantAgreement/ES/MCIU/PID2019-109333RB-I00$$9info:eu-repo/grantAgreement/ES/MCIU/RYC-2013-12570 000109104 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000109104 590__ $$a16.823$$b2021 000109104 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b15 / 180 = 0.083$$c2021$$dQ1$$eT1 000109104 594__ $$a23.9$$b2021 000109104 592__ $$a5.126$$b2021 000109104 593__ $$aChemistry (miscellaneous)$$c2021$$dQ1 000109104 593__ $$aCatalysis$$c2021$$dQ1 000109104 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000109104 700__ $$0(orcid)0000-0002-8263-0473$$aFranco-Castillo, I. 000109104 700__ $$0(orcid)0000-0003-1378-0571$$aRomero, P. 000109104 700__ $$0(orcid)0000-0001-9193-3874$$aMartin, S.$$uUniversidad de Zaragoza 000109104 700__ $$0(orcid)0000-0003-1081-8482$$ade la Fuente, J.M. 000109104 700__ $$0(orcid)0000-0003-4848-414X$$aMitchell, S.G. 000109104 700__ $$0(orcid)0000-0003-0702-8260$$aMartin-Rapun, R.$$uUniversidad de Zaragoza 000109104 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica 000109104 7102_ $$12012$$2755$$aUniversidad de Zaragoza$$bDpto. Química Física$$cÁrea Química Física 000109104 773__ $$g60, 7 (2021), 3449-3453$$pAngew. Chem. (Int. ed.)$$tANGEWANDTE CHEMIE-INTERNATIONAL EDITION$$x1433-7851 000109104 8564_ $$s519050$$uhttps://zaguan.unizar.es/record/109104/files/texto_completo.pdf$$yPostprint 000109104 8564_ $$s1046048$$uhttps://zaguan.unizar.es/record/109104/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000109104 909CO $$ooai:zaguan.unizar.es:109104$$particulos$$pdriver 000109104 951__ $$a2023-05-18-15:20:32 000109104 980__ $$aARTICLE