109104 20230519145518.0 doi 10.1002/anie.202013563 sideral 122246 ART-2021-122246 eng Soria-Carrera, H. (orcid)0000-0002-5823-0314 On-POM Ring-Opening Polymerisation of N-Carboxyanhydrides 2021 Access copy available to the general public Unrestricted The ring-opening polymerisation of a-amino acid N-carboxyanhydrides (NCAs) offers a simple and scalable route to polypeptides with predicted and narrow molecular weight distributions. Here we show how polyoxometalates (POMs)-redox-active molecular metal-oxide anions-can serve as inorganic scaffold initiators for such NCA polymerisations. This "On-POM polymerisation" strategy serves as an innovative platform to design hybrid materials with additive or synergistic properties stemming from the inorganic and polypeptide component parts. We have used this synthetic approach to synthesise a library of bactericidal poly(lysine)-POM hybrid derivatives that can be used to prevent biofilm formation. This versatile "On-POM polymerisation" method provides a flexible synthetic approach for combining inorganic scaffolds with amino acids, and the potential to tailor and improve the specificity and performance of hybrid antimicrobial materials. info:eu-repo/grantAgreement/ES/CSIC/i-Link+2019-LINK20270 info:eu-repo/grantAgreement/ES/DGA-FSE/CIBER-BBN info:eu-repo/grantAgreement/ES/DGA-FSE/E15-20R info:eu-repo/grantAgreement/ES/DGA-FSE/E31-17R info:eu-repo/grantAgreement/ES/DGA-FSE/E47-20R info:eu-repo/grantAgreement/ES/MCIU/PGC2018-097583-B-I00 info:eu-repo/grantAgreement/ES/MCIU/PID2019-105881RB-I00 info:eu-repo/grantAgreement/ES/MCIU/PID2019-109333RB-I00 info:eu-repo/grantAgreement/ES/MCIU/RYC-2013-12570 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 16.823 2021 CHEMISTRY, MULTIDISCIPLINARY 15 / 180 = 0.083 2021 Q1 T1 5.126 2021 Chemistry (miscellaneous) 2021 Q1 Catalysis 2021 Q1 23.9 2021 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Franco-Castillo, I. (orcid)0000-0002-8263-0473 Romero, P. (orcid)0000-0003-1378-0571 Martin, S. Universidad de Zaragoza (orcid)0000-0001-9193-3874 de la Fuente, J.M. (orcid)0000-0003-1081-8482 Mitchell, S.G. (orcid)0000-0003-4848-414X Martin-Rapun, R. Universidad de Zaragoza (orcid)0000-0003-0702-8260 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 2012 755 Universidad de Zaragoza Dpto. Química Física Área Química Física 60, 7 (2021), 3449-3453 Angew. Chem. (Int. ed.) ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 1433-7851 519050 http://zaguan.unizar.es/record/109104/files/texto_completo.pdf Postprint 1046048 http://zaguan.unizar.es/record/109104/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:109104 articulos driver 2023-05-18-15:20:32 ARTICLE