000109327 001__ 109327
000109327 005__ 20220111162035.0
000109327 0247_ $$2doi$$a10.1111/ejn.14127
000109327 0248_ $$2sideral$$a111724
000109327 037__ $$aART-2018-111724
000109327 041__ $$aeng
000109327 100__ $$0(orcid)0000-0002-3380-7252$$aMontagud-Romero, Sandra
000109327 245__ $$aSocial defeat stress: mechanisms underlying the increase in rewarding effects of drugs of abuse
000109327 260__ $$c2018
000109327 5060_ $$aAccess copy available to the general public$$fUnrestricted
000109327 5203_ $$aSocial interaction is known to be the main source of stress in human beings, which explains the translational importance of this research in animals. Evidence reported over the last decade has revealed that, when exposed to social defeat experiences (brief episodes of social confrontations during adolescence and adulthood), the rodent brain undergoes remodeling and functional modifications, which in turn lead to an increase in the rewarding and reinstating effects of different drugs of abuse. The mechanisms by which social stress cause changes in the brain and behavior are unknown, and so the objective of this review is to contemplate how social defeat stress induces longlasting consequences that modify the reward system. First of all, we will describe the most characteristic results of the short-and longterm consequences of social defeat stress on the rewarding effects of drugs of abuse such as psychostimulants and alcohol. Secondly, and throughout the review, we will carefully assess the neurobiological mechanisms underlying these effects, including changes in the dopaminergic system, corticotrophin releasing factor signaling, epigenetic modifications and the neuroinflammatory response. To conclude, we will consider the advantages and disadvantages and the translational value of the social defeat stress model, and will discuss challenges and future directions.
000109327 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/RD12-0028-0005$$9info:eu-repo/grantAgreement/ES/ISCIII/RD16-0017-0007$$9info:eu-repo/grantAgreement/ES/MINECO/PSI2014-51847-R$$9info:eu-repo/grantAgreement/ES/MINECO/PSI2017-83023-R
000109327 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000109327 590__ $$a2.784$$b2018
000109327 591__ $$aNEUROSCIENCES$$b142 / 266 = 0.534$$c2018$$dQ3$$eT2
000109327 592__ $$a1.501$$b2018
000109327 593__ $$aNeuroscience (miscellaneous)$$c2018$$dQ1
000109327 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000109327 700__ $$0(orcid)0000-0001-5990-1266$$aBlanco-Gandía, María Carmen
000109327 700__ $$aReguilón, Marina D.
000109327 700__ $$0(orcid)0000-0002-8890-4869$$aFerrer-Pérez, Carmen
000109327 700__ $$aBallestín, Raul
000109327 700__ $$aMiñarro, José
000109327 700__ $$aRodríguez-Arias, Marta
000109327 773__ $$g48, 9 (2018), 2948-2970$$pEur. j. neurosci.$$tEUROPEAN JOURNAL OF NEUROSCIENCE$$x0953-816X
000109327 8564_ $$s953292$$uhttps://zaguan.unizar.es/record/109327/files/texto_completo.pdf$$yPostprint
000109327 8564_ $$s1006693$$uhttps://zaguan.unizar.es/record/109327/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000109327 909CO $$ooai:zaguan.unizar.es:109327$$particulos$$pdriver
000109327 951__ $$a2022-01-11-13:44:52
000109327 980__ $$aARTICLE