109327 20220111162035.0 doi 10.1111/ejn.14127 sideral 111724 ART-2018-111724 eng Montagud-Romero, Sandra (orcid)0000-0002-3380-7252 Social defeat stress: mechanisms underlying the increase in rewarding effects of drugs of abuse 2018 Social interaction is known to be the main source of stress in human beings, which explains the translational importance of this research in animals. Evidence reported over the last decade has revealed that, when exposed to social defeat experiences (brief episodes of social confrontations during adolescence and adulthood), the rodent brain undergoes remodeling and functional modifications, which in turn lead to an increase in the rewarding and reinstating effects of different drugs of abuse. The mechanisms by which social stress cause changes in the brain and behavior are unknown, and so the objective of this review is to contemplate how social defeat stress induces longlasting consequences that modify the reward system. First of all, we will describe the most characteristic results of the short-and longterm consequences of social defeat stress on the rewarding effects of drugs of abuse such as psychostimulants and alcohol. Secondly, and throughout the review, we will carefully assess the neurobiological mechanisms underlying these effects, including changes in the dopaminergic system, corticotrophin releasing factor signaling, epigenetic modifications and the neuroinflammatory response. To conclude, we will consider the advantages and disadvantages and the translational value of the social defeat stress model, and will discuss challenges and future directions. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/ISCIII/RD12-0028-0005 info:eu-repo/grantAgreement/ES/ISCIII/RD16-0017-0007 info:eu-repo/grantAgreement/ES/MINECO/PSI2014-51847-R info:eu-repo/grantAgreement/ES/MINECO/PSI2017-83023-R info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 2.784 2018 NEUROSCIENCES 142 / 266 = 0.534 2018 Q3 T2 1.501 2018 Neuroscience (miscellaneous) 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Blanco-Gandía, María Carmen (orcid)0000-0001-5990-1266 Reguilón, Marina D. Ferrer-Pérez, Carmen (orcid)0000-0002-8890-4869 Ballestín, Raul Miñarro, José Rodríguez-Arias, Marta 48, 9 (2018), 2948-2970 Eur. j. neurosci. EUROPEAN JOURNAL OF NEUROSCIENCE 0953-816X 953292 http://zaguan.unizar.es/record/109327/files/texto_completo.pdf Postprint 1006693 http://zaguan.unizar.es/record/109327/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:109327 articulos driver 2022-01-11-13:44:52 ARTICLE