000109346 001__ 109346
000109346 005__ 20230519145423.0
000109346 0247_ $$2doi$$a10.3390/nano11112939
000109346 0248_ $$2sideral$$a125469
000109346 037__ $$aART-2021-125469
000109346 041__ $$aeng
000109346 100__ $$aGonçalves, J.
000109346 245__ $$aCoating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency
000109346 260__ $$c2021
000109346 5060_ $$aAccess copy available to the general public$$fUnrestricted
000109346 5203_ $$aMagnetic nanoparticles (NP), such as magnetite, have been the subject of research for application in the biomedical field, especially in Magnetic Hyperthermia Therapy (MHT), a promising technique for cancer therapy. NP are often coated with different compounds such as natural or synthetic polymers to protect them from oxidation and enhance their colloidal electrostatic stability while maintaining their thermal efficiency. In this work, the synthesis and characterization of magnetite nanoparticles coated with fucoidan, a biopolymer with recognized biocompatibility and antitumoral activity, is reported. The potential application of NP in MHT was evaluated through the assessment of Specific Loss Power (SLP) under an electromagnetic field amplitude of 14.7 kA m−1 and at 276 kHz. For fucoidan-coated NP, it was obtained SLP values of 100 and 156 W/g, corresponding to an Intrinsic Loss Power (ILP) of 1.7 and 2.6 nHm2kg−1, respectively. These values are, in general, higher than the ones reported in the literature for non-coated magnetite NP or coated with other polymers. Furthermore, in vitro assays showed that fucoidan and fucoidan-coated NP are biocompatible. The particle size (between ca. 6 to 12 nm), heating efficiency, and biocompatibility of fucoidan-coated magnetite NP meet the required criteria for MHT application.
000109346 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/RYC-2018-024561-I$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 823717-ESTEEM3$$9info:eu-repo/grantAgreement/EC/H2020/823717/EU/Enabling Science and Technology through European Electron Microscopy/ESTEEM3
000109346 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000109346 590__ $$a5.719$$b2021
000109346 592__ $$a0.839$$b2021
000109346 594__ $$a6.6$$b2021
000109346 591__ $$aPHYSICS, APPLIED$$b37 / 161 = 0.23$$c2021$$dQ1$$eT1
000109346 593__ $$aMaterials Science (miscellaneous)$$c2021$$dQ1
000109346 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b109 / 345 = 0.316$$c2021$$dQ2$$eT1
000109346 593__ $$aChemical Engineering (miscellaneous)$$c2021$$dQ1
000109346 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b55 / 180 = 0.306$$c2021$$dQ2$$eT1
000109346 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b53 / 109 = 0.486$$c2021$$dQ2$$eT2
000109346 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000109346 700__ $$aNunes, C.
000109346 700__ $$aFerreira, L.
000109346 700__ $$aCruz, M. M.
000109346 700__ $$aOliveira, H.
000109346 700__ $$aBastos, V.
000109346 700__ $$0(orcid)0000-0002-5229-2717$$aMayoral, A.$$uUniversidad de Zaragoza
000109346 700__ $$aZhang, Q.
000109346 700__ $$aFerreira, P.
000109346 7102_ $$12003$$2395$$aUniversidad de Zaragoza$$bDpto. Física Materia Condensa.$$cÁrea Física Materia Condensada
000109346 773__ $$g11, 11 (2021), 2939 [20 PP.]$$pNanomaterials (Basel)$$tNanomaterials$$x2079-4991
000109346 8564_ $$s3614513$$uhttps://zaguan.unizar.es/record/109346/files/texto_completo.pdf$$yVersión publicada
000109346 8564_ $$s2769182$$uhttps://zaguan.unizar.es/record/109346/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000109346 909CO $$ooai:zaguan.unizar.es:109346$$particulos$$pdriver
000109346 951__ $$a2023-05-18-14:09:30
000109346 980__ $$aARTICLE