000109461 001__ 109461
000109461 005__ 20230519145446.0
000109461 0247_ $$2doi$$a10.1016/j.neuropharm.2021.108753
000109461 0248_ $$2sideral$$a125609
000109461 037__ $$aART-2021-125609
000109461 041__ $$aeng
000109461 100__ $$aGiménez-Gómez, Pablo
000109461 245__ $$aDecreased kynurenine pathway potentiate resilience to social defeat effect on cocaine reward
000109461 260__ $$c2021
000109461 5060_ $$aAccess copy available to the general public$$fUnrestricted
000109461 5203_ $$aThe kynurenine (KYN) pathway of tryptophan (TRP) degradation is activated by stress and inflammatory factors. It is now well established that social stress induces the activation of the immune system, with central inflammation and KYN metabolism being two of the main factors linking stress with depression.
The aim of the present study was to evaluate the long-lasting changes in the KYN pathway induced by social defeat (SD) associated with the resilience or susceptibility to an increase in the conditioned rewarding effects of cocaine. Mice were exposed to repeated SD and 3 weeks later, a conditioned place preference (CPP) induced by a subthreshold dose of cocaine (1.5 mg/kg) was developed. KYN levels in plasma, cerebellum, hippocampus, striatum and limbic forebrain were studied at the end of the CPP procedure. Changes in the KYN pathway after exposure to pharmacological (oxytocin and indomethacin) and environmental interventions (environmental enrichment) were also evaluated.
Our results showed that defeated susceptible (SD-S) mice had higher conditioning scores than resilient mice (SD-R). In addition, although KYN concentration was elevated in all defeated mice, SD-R mice showed smaller increases in KYN concentration in the cerebellum than SD-S mice. Oxytocin or Indomethacin treatment before SD normalized cocaine-induced CPP, although the increase in the KYN pathway was maintained. However, environmental enrichment before SD normalized cocaine-induced CPP and prevented the increase in the KYN pathway.
The present study highlights the role of the KYN pathway and anti-inflammatory drugs acting on TRP metabolism as pharmacological targets to potentiate resilience to social stress effects.
000109461 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-105847RB-I00$$9info:eu-repo/grantAgreement/ES/MINECO/PSI2017-83023-R
000109461 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000109461 590__ $$a5.273$$b2021
000109461 592__ $$a1.323$$b2021
000109461 594__ $$a9.6$$b2021
000109461 591__ $$aPHARMACOLOGY & PHARMACY$$b66 / 279 = 0.237$$c2021$$dQ1$$eT1
000109461 593__ $$aPharmacology$$c2021$$dQ1
000109461 591__ $$aNEUROSCIENCES$$b82 / 275 = 0.298$$c2021$$dQ2$$eT1
000109461 593__ $$aCellular and Molecular Neuroscience$$c2021$$dQ1
000109461 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000109461 700__ $$aBallestín, Raúl
000109461 700__ $$aGil de Biedma-Elduayen, Leticia
000109461 700__ $$aVidal, Rebeca
000109461 700__ $$0(orcid)0000-0002-8890-4869$$aFerrer-Pérez, Carmen$$uUniversidad de Zaragoza
000109461 700__ $$aReguilón, Marina D.
000109461 700__ $$aO'Shea, Esther
000109461 700__ $$aMiñarro, José
000109461 700__ $$aColado, María Isabel
000109461 700__ $$aRodríguez-Arias, Marta
000109461 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000109461 773__ $$g197 (2021), 108753 [16 pp.]$$pNeuropharmacology$$tNEUROPHARMACOLOGY$$x0028-3908
000109461 8564_ $$s6536485$$uhttps://zaguan.unizar.es/record/109461/files/texto_completo.pdf$$yVersión publicada
000109461 8564_ $$s2489004$$uhttps://zaguan.unizar.es/record/109461/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000109461 909CO $$ooai:zaguan.unizar.es:109461$$particulos$$pdriver
000109461 951__ $$a2023-05-18-14:38:39
000109461 980__ $$aARTICLE