000109470 001__ 109470
000109470 005__ 20230519145514.0
000109470 0247_ $$2doi$$a10.3389/fphys.2021.674223
000109470 0248_ $$2sideral$$a125674
000109470 037__ $$aART-2021-125674
000109470 041__ $$aeng
000109470 100__ $$0(orcid)0000-0002-6264-4229$$aRiccio, J$$uUniversidad de Zaragoza
000109470 245__ $$aCharacterization of Atrial Propagation Patterns and Fibrotic Substrate With a Modified Omnipolar Electrogram Strategy in Multi-Electrode Arrays
000109470 260__ $$c2021
000109470 5060_ $$aAccess copy available to the general public$$fUnrestricted
000109470 5203_ $$aIntroduction: The omnipolar electrogram method was recently proposed to try to generate orientation-independent electrograms. It estimates the electric field from the bipolar electrograms of a clique, under the assumption of locally plane and homogeneous propagation. The local electric field evolution over time describes a loop trajectory from which omnipolar signals in the propagation direction, substrate and propagation features, are derived. In this work, we propose substrate and conduction velocity mapping modalities based on a modified version of the omnipolar electrogram method, which aims to reduce orientation-dependent residual components in the standard approach.</p> & nbsp;</p> Methods: A simulated electrical propagation in 2D, with a tissue including a circular patch of diffuse fibrosis, was used for validation. Unipolar electrograms were calculated in a multi-electrode array, also deriving bipolar electrograms along the two main directions of the grid. Simulated bipolar electrograms were also contaminated with real noise, to assess the robustness of the mapping strategies against noise. The performance of the maps in identifying fibrosis and in reproducing unipolar reference voltage maps was evaluated. Bipolar voltage maps were also considered for performance comparison.</p> & nbsp;</p> Results: Results show that the modified omnipolar mapping strategies are more accurate and robust against noise than bipolar and standard omnipolar maps in fibrosis detection (accuracies higher than 85 vs. 80% and 70%, respectively). They present better correlation with unipolar reference voltage maps than bipolar and original omnipolar maps (Pearson''s correlations higher than 0.75 vs. 0.60 and 0.70, respectively).</p> & nbsp;</p> Conclusion: The modified omnipolar method improves fibrosis detection, characterization of substrate and propagation, also reducing the residual sensitivity to directionality over the standard approach and improving robustness against noise. Nevertheless, studies with real electrograms will elucidate its impact in catheter ablation interventions.</p>
000109470 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-104881RB-I00$$9info:eu-repo/grantAgreement/ES/MICINN-FEDER/PID2019-105674RB-I00$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 766082-MY-ATRIA$$9info:eu-repo/grantAgreement/EC/H2020/766082/EU/MultidisciplinarY training network for ATrial fibRillation monItoring, treAtment and progression/MY-ATRIA$$9info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group
000109470 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000109470 590__ $$a4.755$$b2021
000109470 592__ $$a1.126$$b2021
000109470 594__ $$a6.6$$b2021
000109470 591__ $$aPHYSIOLOGY$$b20 / 81 = 0.247$$c2021$$dQ1$$eT1
000109470 593__ $$aPhysiology (medical)$$c2021$$dQ1
000109470 593__ $$aPhysiology$$c2021$$dQ1
000109470 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000109470 700__ $$0(orcid)0000-0002-0166-2837$$aAlcaine, A
000109470 700__ $$aRocher, S
000109470 700__ $$aMartinez-Mateu, L
000109470 700__ $$aLaranjo, S
000109470 700__ $$aSaiz, J
000109470 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, P$$uUniversidad de Zaragoza
000109470 700__ $$0(orcid)0000-0002-7503-3339$$aMartinez, JP$$uUniversidad de Zaragoza
000109470 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000109470 773__ $$g12 (2021)$$pFront. physiol.$$tFRONTIERS IN PHYSIOLOGY$$x1664-042X
000109470 8564_ $$s5678926$$uhttps://zaguan.unizar.es/record/109470/files/texto_completo.pdf$$yVersión publicada
000109470 8564_ $$s2262230$$uhttps://zaguan.unizar.es/record/109470/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000109470 909CO $$ooai:zaguan.unizar.es:109470$$particulos$$pdriver
000109470 951__ $$a2023-05-18-15:14:31
000109470 980__ $$aARTICLE