109470 20230519145514.0 doi 10.3389/fphys.2021.674223 sideral 125674 ART-2021-125674 eng Riccio, J Universidad de Zaragoza (orcid)0000-0002-6264-4229 Characterization of Atrial Propagation Patterns and Fibrotic Substrate With a Modified Omnipolar Electrogram Strategy in Multi-Electrode Arrays 2021 Access copy available to the general public Unrestricted Introduction: The omnipolar electrogram method was recently proposed to try to generate orientation-independent electrograms. It estimates the electric field from the bipolar electrograms of a clique, under the assumption of locally plane and homogeneous propagation. The local electric field evolution over time describes a loop trajectory from which omnipolar signals in the propagation direction, substrate and propagation features, are derived. In this work, we propose substrate and conduction velocity mapping modalities based on a modified version of the omnipolar electrogram method, which aims to reduce orientation-dependent residual components in the standard approach.</p> & nbsp;</p> Methods: A simulated electrical propagation in 2D, with a tissue including a circular patch of diffuse fibrosis, was used for validation. Unipolar electrograms were calculated in a multi-electrode array, also deriving bipolar electrograms along the two main directions of the grid. Simulated bipolar electrograms were also contaminated with real noise, to assess the robustness of the mapping strategies against noise. The performance of the maps in identifying fibrosis and in reproducing unipolar reference voltage maps was evaluated. Bipolar voltage maps were also considered for performance comparison.</p> & nbsp;</p> Results: Results show that the modified omnipolar mapping strategies are more accurate and robust against noise than bipolar and standard omnipolar maps in fibrosis detection (accuracies higher than 85 vs. 80% and 70%, respectively). They present better correlation with unipolar reference voltage maps than bipolar and original omnipolar maps (Pearson''s correlations higher than 0.75 vs. 0.60 and 0.70, respectively).</p> & nbsp;</p> Conclusion: The modified omnipolar method improves fibrosis detection, characterization of substrate and propagation, also reducing the residual sensitivity to directionality over the standard approach and improving robustness against noise. Nevertheless, studies with real electrograms will elucidate its impact in catheter ablation interventions.</p> info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group info:eu-repo/grantAgreement/EC/H2020/766082/EU/MultidisciplinarY training network for ATrial fibRillation monItoring, treAtment and progression/MY-ATRIA This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 766082-MY-ATRIA info:eu-repo/grantAgreement/ES/MICINN-FEDER/PID2019-105674RB-I00 info:eu-repo/grantAgreement/ES/MICINN/PID2019-104881RB-I00 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.755 2021 PHYSIOLOGY 20 / 81 = 0.247 2021 Q1 T1 1.126 2021 Physiology (medical) 2021 Q1 Physiology 2021 Q1 6.6 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Alcaine, A (orcid)0000-0002-0166-2837 Rocher, S Martinez-Mateu, L Laranjo, S Saiz, J Laguna, P Universidad de Zaragoza (orcid)0000-0003-3434-9254 Martinez, JP Universidad de Zaragoza (orcid)0000-0002-7503-3339 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 12 (2021) Front. physiol. FRONTIERS IN PHYSIOLOGY 1664-042X 5678926 http://zaguan.unizar.es/record/109470/files/texto_completo.pdf Versión publicada 2262230 http://zaguan.unizar.es/record/109470/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:109470 articulos driver 2023-05-18-15:14:31 ARTICLE