000109510 001__ 109510
000109510 005__ 20240209144726.0
000109510 0247_ $$2doi$$a10.1016/j.bspc.2021.102719
000109510 0248_ $$2sideral$$a125677
000109510 037__ $$aART-2021-125677
000109510 041__ $$aeng
000109510 100__ $$aPalmieri, Flavio
000109510 245__ $$aECG-based monitoring of blood potassium concentration: Periodic versus principal component as lead transformation for biomarker robustness
000109510 260__ $$c2021
000109510 5060_ $$aAccess copy available to the general public$$fUnrestricted
000109510 5203_ $$aObjective: The aim of this study is to compare the performance of two electrocardiogram (ECG) lead-space reduction (LSR) techniques in generating a transformed ECG lead from which T-wave morphology markers can be reliably derived to non-invasively monitor blood potassium concentration ([K+]) in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). These LSR techniques are: (1) principal component analysis (PCA), learned on the T wave, and (2) periodic component analysis (πCA), either learned on the whole QRST complex (πCB) or on the T wave (πCT). We hypothesized πCA is less sensitive to non-periodic disturbances, like noise and body position changes (BPC), than PCA, thus leading to more reliable T wave morphology markers. Methods: We compared the ability of T wave morphology markers obtained from PCA, πCB and πCT in tracking [K+] in an ESRD-HD dataset, including 29 patients, during and after HD (evaluated by correlation and residual fitting error analysis). We also studied their robustness to BPC using an annotated database, including 20 healthy individuals, as well as to different levels of noise using a simulation set-up (assessed by means of Mann–Whitney U test and relative error, respectively). Results: The performance of both πCB and πCT-based markers in following [K+]-variations during HD was comparable, and superior to that from PCA-based markers. Moreover, πCT-based markers showed superior robustness against BPC and noise. Conclusion: Both πCB and πCT outperform PCA in terms of monitoring [K+] in ESRD-HD patients, as well as of robustness against BPC and low SNR, with πCT showing the highest stability for continuous post-HD monitoring. Significance: The usage of πCA (i) increases the accuracy in monitoring dynamic [K+] variations in ESRD-HD patients and (ii) reduces the sensitivity to BPC and noise in deriving T wave morphology markers. © 2021 The Author(s)
000109510 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-104881RB-I00$$9info:eu-repo/grantAgreement/ES/MICINN-FEDER/PID2019-105674RB-I00$$9info:eu-repo/grantAgreement/EUR/ERC-2014-StG-638284$$9info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group
000109510 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000109510 590__ $$a5.076$$b2021
000109510 592__ $$a1.211$$b2021
000109510 594__ $$a6.9$$b2021
000109510 591__ $$aENGINEERING, BIOMEDICAL$$b30 / 98 = 0.306$$c2021$$dQ2$$eT1
000109510 593__ $$aSignal Processing$$c2021$$dQ1
000109510 593__ $$aHealth Informatics$$c2021$$dQ1
000109510 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000109510 700__ $$aGomis, Pedro
000109510 700__ $$aRuiz, José Esteban
000109510 700__ $$aFerreira, Dina
000109510 700__ $$0(orcid)0000-0003-0226-4950$$aMartín-Yebra, Alba
000109510 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, Esther$$uUniversidad de Zaragoza
000109510 700__ $$0(orcid)0000-0002-7503-3339$$aMartínez, Juan Pablo$$uUniversidad de Zaragoza
000109510 700__ $$0(orcid)0000-0003-4130-5866$$aRamírez, Julia
000109510 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, Pablo$$uUniversidad de Zaragoza
000109510 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000109510 773__ $$g68 (2021), 102719 [11 pp.]$$pBiomed. signal proces. control$$tBiomedical Signal Processing and Control$$x1746-8094
000109510 8564_ $$s3992167$$uhttps://zaguan.unizar.es/record/109510/files/texto_completo.pdf$$yVersión publicada
000109510 8564_ $$s2426403$$uhttps://zaguan.unizar.es/record/109510/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000109510 909CO $$ooai:zaguan.unizar.es:109510$$particulos$$pdriver
000109510 951__ $$a2024-02-09-14:45:41
000109510 980__ $$aARTICLE