109514 20230519145559.0 doi 10.3390/biomedicines9121775 sideral 125912 ART-2021-125912 eng Abás E. Universidad de Zaragoza (orcid)0000-0002-6674-7364 Selective anticancer and antimicrobial metallodrugs based on Gold(III) dithiocarbamate complexes 2021 Access copy available to the general public Unrestricted New dithiocarbamate cycloaurated complexes have been synthesized and their physicochemical and in vitro antitumor properties have been evaluated. All the performed studies highlighted good transport through the blood and biodistribution, according to the balance between the properties of hydrophilicity/lipophilicity and the binding of moderate strength to the BSA protein. Furthermore, none of the complexes exhibited reduction or decomposition reactions, presenting excellent physiological stability. The in vitro cytotoxic effect was evaluated on human colon cancer cell line Caco-2/TC7, and the complexes showed great antiproliferative activity and excellent selectivity, as much less effect was detected on normal Caco-2/TC7 cells. Most of the complexes exhibit antiproliferative activity that was better than or similar to auranofin, and at least nine times better than that of cisplatin. Its action mechanism is still under discussion since no evidence of cell cycle arrest was found, but an antioxidant role was shown for some of the selective complexes. All complexes were also tested as antimicrobial drugs, exhibiting good activity towards S. aureus and E. coli. bacteria and C. albicans and C. neoformans fungi. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). info:eu-repo/grantAgreement/ES/DGA/A20-20R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.757 2021 BIOCHEMISTRY & MOLECULAR BIOLOGY 121 / 297 = 0.407 2021 Q2 T2 PHARMACOLOGY & PHARMACY 87 / 279 = 0.312 2021 Q2 T1 MEDICINE, RESEARCH & EXPERIMENTAL 62 / 140 = 0.443 2021 Q2 T2 0.874 2021 Medicine (miscellaneous) 2021 Q1 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2021 Q1 3.0 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Aguirre-Ramírez D. (orcid)0000-0002-1829-6319 Laguna M. (orcid)0000-0002-5801-3352 Grasa L. Universidad de Zaragoza (orcid)0000-0002-5306-9365 2009 750 Universidad de Zaragoza Dpto. Química Analítica Área Química Analítica 1012 410 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Fisiología 9, 12 (2021), [18 pp] Biomedicines 2227-9059 1860276 http://zaguan.unizar.es/record/109514/files/texto_completo.pdf Versión publicada 2826554 http://zaguan.unizar.es/record/109514/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:109514 articulos driver 2023-05-18-15:58:29 ARTICLE