109543 20240122154815.0 doi 10.3390/nu13061838 sideral 127165 ART-2021-127165 eng Martínez-Beamonte, R. Universidad de Zaragoza (orcid)0000-0002-8100-5596 Dietary avian proteins are comparable to soybean proteins on the atherosclerosis development and fatty liver disease in apoe-deficient mice 2021 Access copy available to the general public Unrestricted Background and aim: The type and amount of dietary protein has become a topic of re-newed interest in light of their involvement in metabolic diseases, atherosclerosis and thrombosis. However, little attention has been devoted to the effect of avian proteins despite their wide human consumption. The aim was to investigate the influence of chicken and turkey as sources of protein compared with that of soybean on atherosclerosis and fatty liver disease. Methods and results: To this purpose, male and female Apoe-deficient were fed purified Western diets differing in their protein sources for 12 weeks. After this period, blood, liver, aortic tree and heart base samples were taken for analyses of plasma lipids and atherosclerosis. Plasma triglycerides, non-esterified fatty acids, esterified cholesterol levels and radical oxygen species in lipoproteins changed depending on the diet and sex. Females consuming the turkey protein-containing diet showed decreased athero-sclerotic foci, as evidenced by the en face atherosclerosis analyses. The presence of macrophages and smooth muscle cells in plaques were not modified, and no changes were observed in hepatic lipid droplets in the studied groups either. Paraoxonase activity was higher in the group consuming turkey protein without sex differences, but only in females, it was significantly associated with aor-tic lesion areas. Conclusions: Compared to soybean protein, the consumption of avian proteins depending on sex resulted in similar or lower atherosclerosis development and comparable hepatic steatosis. info:eu-repo/grantAgreement/ES/CIBERObn/CB06-03-1012 info:eu-repo/grantAgreement/ES/DGA/B16-20R info:eu-repo/grantAgreement/ES/MICINN AEI/PID2019-104915RB-I00 info:eu-repo/grantAgreement/ES/MICINN/SAF2016-75441-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 6.706 2021 NUTRITION & DIETETICS 15 / 90 = 0.167 2021 Q1 T1 1.287 2021 Nutrition and Dietetics 2021 Q1 Food Science 2021 Q1 7.9 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Sánchez-Marco, J. (orcid)0000-0002-9023-741X Lázaro, G. Barco, M. Herrero-Continente, T. Serrano-Megías, M. Botaya, D. Arnal, C. Universidad de Zaragoza (orcid)0000-0003-1197-4276 Barranquero, C. (orcid)0000-0002-8442-8041 Surra, J.C. Universidad de Zaragoza (orcid)0000-0002-5841-0462 Osada, J. Universidad de Zaragoza (orcid)0000-0002-8251-8457 Navarro, M.A. Universidad de Zaragoza (orcid)0000-0002-0108-1004 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 2008 700 Universidad de Zaragoza Dpto. Produc.Animal Cienc.Ali. Área Producción Animal 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 1002 050 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Biología Celular 13, 6 (2021), 1838 [14 pp.] Nutrients Nutrients 2072-6643 1337191 http://zaguan.unizar.es/record/109543/files/texto_completo.pdf Versión publicada 2735340 http://zaguan.unizar.es/record/109543/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:109543 articulos driver 2024-01-22-15:40:21 ARTICLE