000109570 001__ 109570
000109570 005__ 20230519145342.0
000109570 0247_ $$2doi$$a10.1007/s00418-021-01965-2
000109570 0248_ $$2sideral$$a122522
000109570 037__ $$aART-2021-122522
000109570 041__ $$aeng
000109570 100__ $$aIruzubieta, Pablo
000109570 245__ $$aPrimary cilia presence and implications in bladder cancer progression and invasiveness
000109570 260__ $$c2021
000109570 5060_ $$aAccess copy available to the general public$$fUnrestricted
000109570 5203_ $$aUrothelial bladder cancer is the tenth most common cancer worldwide. It is divided into muscle and non-muscle invading bladder cancer. Primary cilia have been related to several cancer hallmarks such as proliferation, epithelial-to-mesenchymal transition (EMT) or tumoral progression mainly through signaling pathways as Hedgehog (Hh). In the present study, we used immunohistochemical and ultrastructural techniques in human tissues of healthy bladder, non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC) to study and clarify the activation of epithelial-to-mesenchymal transition and Hedgehog signaling pathway and the presence of primary cilia. Thus, we found a clear correlation between EMT and Hedgehog activation and bladder cancer stage and progression. Moreover, we identified the presence of primary cilia in these tissues. Interestingly, we found that in NMIBC, some ciliated cells cross the basement membrane and localized in lamina propria, near blood vessels. These results show a correlation between EMT beginning from urothelial basal cells and primary cilia assembly and suggest a potential implication of this structure in tumoral migration and invasiveness (likely in a Hh-dependent way). Hence, primary cilia may play a fundamental role in urothelial bladder cancer progression and suppose a potential therapeutic target.
000109570 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000109570 590__ $$a2.531$$b2021
000109570 592__ $$a0.944$$b2021
000109570 594__ $$a7.3$$b2021
000109570 591__ $$aMICROSCOPY$$b4 / 9 = 0.444$$c2021$$dQ2$$eT2
000109570 593__ $$aHistology$$c2021$$dQ1
000109570 591__ $$aCELL BIOLOGY$$b163 / 195 = 0.836$$c2021$$dQ4$$eT3
000109570 593__ $$aMolecular Biology$$c2021$$dQ1
000109570 593__ $$aMedical Laboratory Technology$$c2021$$dQ1
000109570 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000109570 700__ $$0(orcid)0000-0001-7453-2470$$aCastiella, Tomás
000109570 700__ $$0(orcid)0000-0002-7453-1766$$aMonleón, Eva$$uUniversidad de Zaragoza
000109570 700__ $$aBerga, Carmen
000109570 700__ $$0(orcid)0000-0001-8567-4327$$aMuñoz, Guillermo$$uUniversidad de Zaragoza
000109570 700__ $$0(orcid)0000-0002-9951-1075$$aJunquera, Concepción.$$uUniversidad de Zaragoza
000109570 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000109570 7102_ $$11013$$2020$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Anatomía Patológica
000109570 773__ $$g155 (2021), 547–560$$pHistochem. cell biol.$$tHISTOCHEMISTRY AND CELL BIOLOGY$$x0948-6143
000109570 8564_ $$s7681217$$uhttps://zaguan.unizar.es/record/109570/files/texto_completo.pdf$$yPostprint
000109570 8564_ $$s2417243$$uhttps://zaguan.unizar.es/record/109570/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000109570 909CO $$ooai:zaguan.unizar.es:109570$$particulos$$pdriver
000109570 951__ $$a2023-05-18-13:16:45
000109570 980__ $$aARTICLE