000109585 001__ 109585
000109585 005__ 20240319080946.0
000109585 0247_ $$2doi$$a10.1038/s41390-021-01519-1
000109585 0248_ $$2sideral$$a125747
000109585 037__ $$aART-2022-125747
000109585 041__ $$aeng
000109585 100__ $$aSalazar-Tortosa, D. F.
000109585 245__ $$aInterplay of physical activity and genetic variants of the endothelial lipase on cardiovascular disease risk factors
000109585 260__ $$c2022
000109585 5060_ $$aAccess copy available to the general public$$fUnrestricted
000109585 5203_ $$aBackground: The aim of this study was to investigate the association of endothelial lipase gene (LIPG) polymorphisms with cardiovascular disease (CVD) risk factors in adolescents and their interaction with physical activity. Methods Six polymorphisms of LIPG were genotyped in 1057 European adolescents (12-18 years old) enrolled in the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) Study. CVD risk factors related to lipid profile, blood pressure, adiposity and glucose regulation were recorded. Physical activity was objectively measured by accelerometry. Results: The major C allele of rs2000813, the minor T allele of rs2276269 and the minor G allele of rs9951026 were associated with lower levels of several CVD risk factors related to lipid profile. We also found a significant association of the TTACA LIPG haplotype (rs2000812, rs2000813, rs8093249, rs2276269 and rs9951026) with higher concentrations of low-density cholesterol and apolipoprotein B. Finally, the interaction between physical activity and the polymorphisms rs2000813, rs2276269 and rs9951026 had a significant influence on several CVD risk factors. Conclusions: LIPG polymorphisms were significantly associated with CVD risk factors in European adolescents. Interestingly, alleles of these polymorphisms were associated with a better cardiovascular profile in physically active adolescents only. High physical activity may reduce the development of CVD, modulating its genetic risk. Impact: Using gene-phenotype and gene x environment analyses, we detected associations between the endothelial lipase gene and cardiovascular risk factors, along with interactions with physical activity. This study shows that physical activity may modulate the influence of gene on cardiovascular risk in adolescents. These results bring insights into the mechanisms by which physical activity positively influences CVD in adolescents.
000109585 536__ $$9info:eu-repo/grantAgreement/ES/MEC/FPU16-02127$$9info:eu-repo/grantAgreement/ES/MEC/FPU13-03410$$9info:eu-repo/grantAgreement/EUR/FP6/FOOD-CT-2005-007034
000109585 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000109585 590__ $$a3.6$$b2022
000109585 591__ $$aPEDIATRICS$$b23 / 130 = 0.177$$c2022$$dQ1$$eT1
000109585 594__ $$a6.1$$b2022
000109585 592__ $$a1.04$$b2022
000109585 593__ $$aPediatrics, Perinatology and Child Health$$c2022$$dQ1
000109585 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000109585 700__ $$aPascual-Gamarra, J. M.
000109585 700__ $$aLabayen, I.
000109585 700__ $$aRupérez, A. I.
000109585 700__ $$aCensi, L.
000109585 700__ $$aBeghin, L.
000109585 700__ $$aMichels, N.
000109585 700__ $$aGonzález-Gross, M.
000109585 700__ $$aManios, Y.
000109585 700__ $$aLambrinou, C. P.
000109585 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L. A.$$uUniversidad de Zaragoza
000109585 700__ $$aMeirhaeghe, A.
000109585 700__ $$aCastillo, M. J.
000109585 700__ $$aRuiz, J. R.
000109585 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000109585 773__ $$g91 (2022), 929–936$$pPediatr. res.$$tPediatric research$$x0031-3998
000109585 8564_ $$s693192$$uhttps://zaguan.unizar.es/record/109585/files/texto_completo.pdf$$yPostprint
000109585 8564_ $$s1229706$$uhttps://zaguan.unizar.es/record/109585/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000109585 909CO $$ooai:zaguan.unizar.es:109585$$particulos$$pdriver
000109585 951__ $$a2024-03-18-12:34:47
000109585 980__ $$aARTICLE