109592 20230519145407.0 doi 10.1007/s10237-020-01415-3 sideral 123309 ART-2021-123309 eng Escuer, J. (orcid)0000-0001-7620-3355 Influence of vessel curvature and plaque composition on drug transport in the arterial wall following drug-eluting stent implantation 2021 Access copy available to the general public Unrestricted In the last decade, many computational models have been developed to describe the transport of drug eluted from stents and the subsequent uptake into arterial tissue. Each of these models has its own set of limitations: for example, models typically employ simplified stent and arterial geometries, some models assume a homogeneous arterial wall, and others neglect the influence of blood flow and plasma filtration on the drug transport process. In this study, we focus on two common limitations. Specifically, we provide a comprehensive investigation of the influence of arterial curvature and plaque composition on drug transport in the arterial wall following drug-eluting stent implantation. The arterial wall is considered as a three-layered structure including the subendothelial space, the media and the adventitia, with porous membranes separating them (endothelium, internal and external elastic lamina). Blood flow is modelled by the Navier–Stokes equations, while Darcy’s law is used to calculate plasma filtration through the porous layers. Our findings demonstrate that arterial curvature and plaque composition have important influences on the spatiotemporal distribution of drug, with potential implications in terms of effectiveness of the treatment. Since the majority of computational models tend to neglect these features, these models are likely to be under- or over-estimating drug uptake and redistribution in arterial tissue. info:eu-repo/grantAgreement/ES/DGA-FSE/T24-17R info:eu-repo/grantAgreement/ES/DGA/LMP121-18 info:eu-repo/grantAgreement/ES/ISCIII/CIBER info:eu-repo/grantAgreement/ES/MINECO/BES-2014-069737 info:eu-repo/grantAgreement/ES/MINECO/DPI2016-76630-C2-1-R info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.623 2021 BIOPHYSICS 32 / 72 = 0.444 2021 Q2 T2 ENGINEERING, BIOMEDICAL 55 / 98 = 0.561 2021 Q3 T2 0.761 2021 Mechanical Engineering 2021 Q1 Biotechnology 2021 Q1 5.3 2021 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Aznar, I. McCormick, C. Peña, E. Universidad de Zaragoza (orcid)0000-0002-0664-5024 McGinty, S. Martínez, M.A. Universidad de Zaragoza (orcid)0000-0002-8375-0354 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. (2021), [20 pp] Biomech. model. mechanobiol. BIOMECHANICS AND MODELING IN MECHANOBIOLOGY 1617-7959 1904576 http://zaguan.unizar.es/record/109592/files/texto_completo.pdf Postprint 2458208 http://zaguan.unizar.es/record/109592/files/texto_completo.jpg?subformat=icon icon Postprint https://rdcu.be/cf8sk Texto completo de la revista oai:zaguan.unizar.es:109592 articulos driver 2023-05-18-13:48:31 ARTICLE