000109637 001__ 109637
000109637 005__ 20230519145507.0
000109637 0247_ $$2doi$$a10.3390/ijms22105279
000109637 0248_ $$2sideral$$a126110
000109637 037__ $$aART-2021-126110
000109637 041__ $$aeng
000109637 100__ $$aGonzalez-Portilla, Macarena
000109637 245__ $$aPairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice
000109637 260__ $$c2021
000109637 5060_ $$aAccess copy available to the general public$$fUnrestricted
000109637 5203_ $$aAlcohol binge drinking (BD) and poor nutritional habits are two frequent behaviors among many adolescents that alter gut microbiota in a pro-inflammatory direction. Dysbiotic changes in the gut microbiome are observed after alcohol and high-fat diet (HFD) consumption, even before obesity onset. In this study, we investigate the neuroinflammatory response of adolescent BD when combined with a continuous or intermittent HFD and its effects on adult ethanol consumption by using a self-administration (SA) paradigm in mice. The inflammatory biomarkers IL-6 and CX3CL1 were measured in the striatum 24 h after BD, 3 weeks later and after the ethanol (EtOH) SA. Adolescent BD increased alcohol consumption in the oral SA and caused a greater motivation to seek the substance. Likewise, mice with intermittent access to HFD exhibited higher EtOH consumption, while the opposite effect was found in mice with continuous HFD access. Biochemical analyses showed that after BD and three weeks later, striatal levels of IL-6 and CX3CL1 were increased. In addition, in saline-treated mice, CX3CL1 was increased after continuous access to HFD. After oral SA procedure, striatal IL-6 was increased only in animals exposed to BD and HFD. In addition, striatal CX3CL1 levels were increased in all BD- and HFD-exposed groups. Overall, our findings show that adolescent BD and intermittent HFD increase adult alcohol intake and point to neuroinflammation as an important mechanism modulating this interaction.021 by the authors. Licensee MDPI, Basel, Switzerland.
000109637 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000109637 590__ $$a6.208$$b2021
000109637 592__ $$a1.176$$b2021
000109637 594__ $$a6.9$$b2021
000109637 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b69 / 297 = 0.232$$c2021$$dQ1$$eT1
000109637 593__ $$aComputer Science Applications$$c2021$$dQ1
000109637 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b50 / 180 = 0.278$$c2021$$dQ2$$eT1
000109637 593__ $$aInorganic Chemistry$$c2021$$dQ1
000109637 593__ $$aSpectroscopy$$c2021$$dQ1
000109637 593__ $$aOrganic Chemistry$$c2021$$dQ1
000109637 593__ $$aPhysical and Theoretical Chemistry$$c2021$$dQ1
000109637 593__ $$aMolecular Biology$$c2021$$dQ1
000109637 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000109637 700__ $$0(orcid)0000-0002-3380-7252$$aMontagud-Romero, Sandra$$uUniversidad de Zaragoza
000109637 700__ $$aNavarrete, Francisco
000109637 700__ $$aGasparyan, Ani
000109637 700__ $$aManzanares, Jorge
000109637 700__ $$aMinarro, José
000109637 700__ $$aRodriguez-Arias, Marta
000109637 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000109637 773__ $$g22, 10 (2021), 5279 [23 pp]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000109637 8564_ $$s2932740$$uhttps://zaguan.unizar.es/record/109637/files/texto_completo.pdf$$yVersión publicada
000109637 8564_ $$s2782659$$uhttps://zaguan.unizar.es/record/109637/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000109637 909CO $$ooai:zaguan.unizar.es:109637$$particulos$$pdriver
000109637 951__ $$a2023-05-18-15:06:39
000109637 980__ $$aARTICLE