000109645 001__ 109645
000109645 005__ 20230519145429.0
000109645 0247_ $$2doi$$a10.1063/5.0061499
000109645 0248_ $$2sideral$$a125468
000109645 037__ $$aART-2021-125468
000109645 041__ $$aeng
000109645 100__ $$aGoya, G. F.
000109645 245__ $$aNext generation of nanozymes: a perspective of the challenges to match biological performance
000109645 260__ $$c2021
000109645 5060_ $$aAccess copy available to the general public$$fUnrestricted
000109645 5203_ $$aNanomaterials with enzyme-like activity have been the spotlight of scientific and technological efforts to substitute natural enzymes, not only in biological research but also for industrial manufacturing, medicine, and environment healing. Notable advancements in this field along the last years relied on to the rational design of single-atom active sites, knowledge of the underlying atomic structure, and realistic abinitio theoretical models of the electronic configuration at the active site. Thus, it is plausible that a next generation of nanozymes still to come will show even improved catalytic efficiency and substrate specificity. However, the dynamic nature of the protein cage surrounding most active sites in biological enzymes adds a flexible functionality that possess a challenge for nanozyme’s mimicking of their natural counterparts. We offer a perspective about where the main strategies to improve nanozymes are headed and identify some of the big challenges faced along the road to better performance. We also outline some of the most exciting bio-inspired ideas that could potentially change this field.
000109645 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E13-20R$$9info:eu-repo/grantAgreement/ES/DGA/E28-20R$$9info:eu-repo/grantAgreement/EC/H2020/101007629 /EU/Nanomaterials for Enzymatic Control of Oxidative Stress Toxicity and Free Radical Generation/NESTOR$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101007629 -NESTOR$$9info:eu-repo/grantAgreement/EC/H2020/823717/EU/Enabling Science and Technology through European Electron Microscopy/ESTEEM3$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 823717-ESTEEM3$$9info:eu-repo/grantAgreement/ES/MCIU/RTC-2017-6620-1$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-106947RB-C21
000109645 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000109645 590__ $$a2.877$$b2021
000109645 592__ $$a0.668$$b2021
000109645 594__ $$a4.7$$b2021
000109645 591__ $$aPHYSICS, APPLIED$$b74 / 161 = 0.46$$c2021$$dQ2$$eT2
000109645 593__ $$aPhysics and Astronomy (miscellaneous)$$c2021$$dQ2
000109645 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000109645 700__ $$0(orcid)0000-0002-5229-2717$$aMayoral, A.$$uUniversidad de Zaragoza
000109645 700__ $$aWinkler, E.
000109645 700__ $$aZysler, R. D.
000109645 700__ $$aBagnato, C.
000109645 700__ $$aRaineri, M.
000109645 700__ $$aFuentes-García, J. A.
000109645 700__ $$aLima, E.
000109645 7102_ $$12003$$2395$$aUniversidad de Zaragoza$$bDpto. Física Materia Condensa.$$cÁrea Física Materia Condensada
000109645 773__ $$g130, 19 (2021), 190903-23$$pJ. appl. physi.$$tJournal of Applied Physics$$x0021-8979
000109645 8564_ $$s9087540$$uhttps://zaguan.unizar.es/record/109645/files/texto_completo.pdf$$yVersión publicada
000109645 8564_ $$s1431370$$uhttps://zaguan.unizar.es/record/109645/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000109645 909CO $$ooai:zaguan.unizar.es:109645$$particulos$$pdriver
000109645 951__ $$a2023-05-18-14:16:29
000109645 980__ $$aARTICLE