109645 20230519145429.0 doi 10.1063/5.0061499 sideral 125468 ART-2021-125468 eng Goya, G. F. Next generation of nanozymes: a perspective of the challenges to match biological performance 2021 Access copy available to the general public Unrestricted Nanomaterials with enzyme-like activity have been the spotlight of scientific and technological efforts to substitute natural enzymes, not only in biological research but also for industrial manufacturing, medicine, and environment healing. Notable advancements in this field along the last years relied on to the rational design of single-atom active sites, knowledge of the underlying atomic structure, and realistic abinitio theoretical models of the electronic configuration at the active site. Thus, it is plausible that a next generation of nanozymes still to come will show even improved catalytic efficiency and substrate specificity. However, the dynamic nature of the protein cage surrounding most active sites in biological enzymes adds a flexible functionality that possess a challenge for nanozyme’s mimicking of their natural counterparts. We offer a perspective about where the main strategies to improve nanozymes are headed and identify some of the big challenges faced along the road to better performance. We also outline some of the most exciting bio-inspired ideas that could potentially change this field. info:eu-repo/grantAgreement/ES/DGA/E13-20R info:eu-repo/grantAgreement/ES/DGA/E28-20R info:eu-repo/grantAgreement/EC/H2020/101007629 /EU/Nanomaterials for Enzymatic Control of Oxidative Stress Toxicity and Free Radical Generation/NESTOR This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101007629 -NESTOR info:eu-repo/grantAgreement/EC/H2020/823717/EU/Enabling Science and Technology through European Electron Microscopy/ESTEEM3 This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 823717-ESTEEM3 info:eu-repo/grantAgreement/ES/MCIU/RTC-2017-6620-1 info:eu-repo/grantAgreement/ES/MICINN/PID2019-106947RB-C21 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 2.877 2021 PHYSICS, APPLIED 74 / 161 = 0.46 2021 Q2 T2 0.668 2021 Physics and Astronomy (miscellaneous) 2021 Q2 4.7 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Mayoral, A. Universidad de Zaragoza (orcid)0000-0002-5229-2717 Winkler, E. Zysler, R. D. Bagnato, C. Raineri, M. Fuentes-García, J. A. Lima, E. 2003 395 Universidad de Zaragoza Dpto. Física Materia Condensa. Área Física Materia Condensada 130, 19 (2021), 190903-23 J. appl. physi. Journal of Applied Physics 0021-8979 9087540 http://zaguan.unizar.es/record/109645/files/texto_completo.pdf Versión publicada 1431370 http://zaguan.unizar.es/record/109645/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:109645 articulos driver 2023-05-18-14:16:29 ARTICLE