109688 20230519145550.0 doi 10.3390/ph14070603 sideral 126730 ART-2021-126730 eng Perez-Laguna, V Photodynamic Therapy Combined with Antibiotics or Antifungals against Microorganisms That Cause Skin and Soft Tissue Infections: A Planktonic and Biofilm Approach to Overcome Resistances 2021 Access copy available to the general public Unrestricted The present review covers combination approaches of antimicrobial photodynamic therapy (aPDT) plus antibiotics or antifungals to attack bacteria and fungi in vitro (both planktonic and biofilm forms) focused on those microorganisms that cause infections in skin and soft tissues. The combination can prevent failure in the fight against these microorganisms: antimicrobial drugs can increase the susceptibility of microorganisms to aPDT and prevent the possibility of regrowth of those that were not inactivated during the irradiation; meanwhile, aPDT is effective regardless of the resistance pattern of the strain and their use does not contribute to the selection of antimicrobial resistance. Additive or synergistic antimicrobial effects in vitro are evaluated and the best combinations are presented. The use of combined treatment of aPDT with antimicrobials could help overcome the difficulty of fighting high level of resistance microorganisms and, as it is a multi-target approach, it could make the selection of resistant microorganisms more difficult. info:eu-repo/grantAgreement/ES/DGA/B10-17R info:eu-repo/grantAgreement/ES/ISCIII-REIPI/RD16-0016-0001 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.215 2021 PHARMACOLOGY & PHARMACY 69 / 279 = 0.247 2021 Q1 T1 CHEMISTRY, MEDICINAL 16 / 63 = 0.254 2021 Q2 T1 0.851 2021 Pharmaceutical Science 2021 Q1 Drug Discovery 2021 Q1 4.0 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Garcia-Luque, I Ballesta, S Rezusta López, A Universidad de Zaragoza (orcid)0000-0001-7294-245X Gilaberte Calzada, Y Universidad de Zaragoza (orcid)0000-0001-8034-3617 1011 630 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Microbiología 1007 183 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Área Dermatología 14, 7 (2021), 603 [21 pp] Pharmaceuticals Pharmaceuticals 1424-8247 668581 http://zaguan.unizar.es/record/109688/files/texto_completo.pdf Versión publicada 2689437 http://zaguan.unizar.es/record/109688/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:109688 articulos driver 2023-05-18-15:50:00 ARTICLE