109706 20230519145555.0 doi 10.3390/pharmaceutics13121988 sideral 126772 ART-2021-126772 eng Arauzo, B. Universidad de Zaragoza (orcid)0000-0002-1407-5922 Excipient-free inhalable microparticles of Azithromycin produced by electrospray: A novel approach to direct pulmonary delivery of antibiotics 2021 Access copy available to the general public Unrestricted Inhalation therapy offers several advantages in respiratory disease treatment. Azithromycin is a macrolide antibiotic with poor solubility and bioavailability but with a high potential to be used to fight lung infections. The main objective of this study was to generate a new inhalable dry powder azithromycin formulation. To this end, an electrospray was used, yielding a particle size around 2.5 µm, which is considered suitable to achieve total deposition in the respiratory system. The physicochemical properties and morphology of the obtained microparticles were analysed with a battery of characterization techniques. In vitro deposition assays were evaluated after aerosolization of the powder at constant flow rate (100 L/min) and the consideration of the simulation of two different realistic breathing profiles (healthy and chronic obstructive pulmonary disease (COPD) patients) into a next generation impactor (NGI). The formulation was effective in vitro against two types of bacteria, Staphylococcus aureus and Pseudomonas aeruginosa. Finally, the particles were biocompatible, as evidenced by tests on the alveolar cell line (A549) and bronchial cell line (Calu-3). © 2021 by the authors. Licensee MDPI, Basel, Switzerland. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 6.525 2021 PHARMACOLOGY & PHARMACY 39 / 279 = 0.14 2021 Q1 T1 0.922 2021 Pharmaceutical Science 2021 Q1 6.0 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Lopez-Mendez, T.B. Lobera, M.P. Universidad de Zaragoza (orcid)0000-0002-2436-1041 Calzada-Funes, J. Universidad de Zaragoza (orcid)0000-0002-1603-7305 Pedraz, J.L. Santamaria, J. Universidad de Zaragoza (orcid)0000-0002-8701-9745 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 13, 12 (2021), 1988 [17 pp] Pharmaceutics Pharmaceutics 1999-4923 11148143 http://zaguan.unizar.es/record/109706/files/texto_completo.pdf Versión publicada 2763176 http://zaguan.unizar.es/record/109706/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:109706 articulos driver 2023-05-18-15:54:28 ARTICLE