000109710 001__ 109710 000109710 005__ 20230519145556.0 000109710 0247_ $$2doi$$a10.3390/biom11121762 000109710 0248_ $$2sideral$$a126776 000109710 037__ $$aART-2021-126776 000109710 041__ $$aeng 000109710 100__ $$aMartins, A.C. 000109710 245__ $$aBXD recombinant inbred mice as a model to study neurotoxicity 000109710 260__ $$c2021 000109710 5060_ $$aAccess copy available to the general public$$fUnrestricted 000109710 5203_ $$aBXD recombinant inbred (RI) lines represent a genetic reference population derived from a cross between C57BL/6J mice (B6) and DBA/2J mice (D2), which through meiotic recombination events possesses recombinant chromosomes containing B6 or D2 haplotype segments. The quantitative trait loci (QTLs) are the locations of segregating genetic polymorphisms and are fundamental to understanding genetic diversity in human disease susceptibility and severity. QTL mapping represents the typical approach for identifying naturally occurring polymorphisms that influence complex phenotypes. In this process, genotypic values at markers of known genomic locations are associated with phenotypic values measured in a segregating population. Indeed, BXD RI strains provide a powerful tool to study neurotoxicity induced by different substances. In this review, we describe the use of BXD RI lines to understand the underlying mechanisms of neurotoxicity in response to ethanol and cocaine, as well as metals and pesticide exposures. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. 000109710 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000109710 590__ $$a6.064$$b2021 000109710 592__ $$a1.019$$b2021 000109710 594__ $$a5.7$$b2021 000109710 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b75 / 297 = 0.253$$c2021$$dQ2$$eT1 000109710 593__ $$aMolecular Biology$$c2021$$dQ2 000109710 593__ $$aBiochemistry$$c2021$$dQ2 000109710 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000109710 700__ $$0(orcid)0000-0001-6767-8252$$aLópez-Granero, C.$$uUniversidad de Zaragoza 000109710 700__ $$aFerrer, B. 000109710 700__ $$aTinkov, A.A. 000109710 700__ $$aSkalny, A.V. 000109710 700__ $$aPaoliello, M.M.B. 000109710 700__ $$aAschner, M. 000109710 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica 000109710 773__ $$g11, 12 (2021), 1762 [12 pp]$$tBiomolecules$$x2218-273X 000109710 8564_ $$s310188$$uhttps://zaguan.unizar.es/record/109710/files/texto_completo.pdf$$yVersión publicada 000109710 8564_ $$s2779577$$uhttps://zaguan.unizar.es/record/109710/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000109710 909CO $$ooai:zaguan.unizar.es:109710$$particulos$$pdriver 000109710 951__ $$a2023-05-18-15:55:18 000109710 980__ $$aARTICLE