000109713 001__ 109713
000109713 005__ 20230519145556.0
000109713 0247_ $$2doi$$a10.1186/s12966-021-01205-9
000109713 0248_ $$2sideral$$a126779
000109713 037__ $$aART-2021-126779
000109713 041__ $$aeng
000109713 100__ $$aMasip, G.
000109713 245__ $$aThe temporal relationship between parental concern of overeating and childhood obesity considering genetic susceptibility: longitudinal results from the IDEFICS/I.Family study
000109713 260__ $$c2021
000109713 5060_ $$aAccess copy available to the general public$$fUnrestricted
000109713 5203_ $$aBackground: Many genes and molecular pathways are associated with obesity, but the mechanisms from genes to obesity are less well known. Eating behaviors represent a plausible pathway, but because the relationships of eating behaviors and obesity may be bi-directional, it remains challenging to resolve the underlying pathways. A longitudinal approach is needed to assess the contribution of genetic risk during the development of obesity in childhood. In this study we aim to examine the relationships between the polygenic risk score for body mass index (PRS-BMI), parental concern of overeating and obesity indices during childhood. Methods: The IDEFICS/I.Family study is a school-based multicenter pan-European cohort of children observed for 6 years (mean ± SD follow-up 5.8 ± 0.4). Children examined in 2007/2008 (wave 1) (mean ± SD age: 4.4 ± 1.1, range: 2–9 years), in 2009/2010 (wave 2) and in 2013/2014 (wave 3) were included. A total of 5112 children (49% girls) participated at waves 1, 2 and 3. For 2656 children with genome-wide data we constructed a PRS based on 2.1 million single nucleotide polymorphisms. Z-score BMI and z-score waist circumference (WC) were assessed and eating behaviors and relevant confounders were reported by parents via questionnaires. Parental concern of overeating was derived from principal component analyses from an eating behavior questionnaire. Results: In cross-lagged models, the prospective associations between z-score obesity indices and parental concern of overeating were bi-directional. In mediation models, the association between the PRS-BMI and parental concern of overeating at wave 3 was mediated by baseline z-BMI (ß = 0.16, 95% CI: 0.10, 0.21) and baseline z-WC (ß = 0.17, 95% CI: 0.11, 0.23). To a lesser extent, baseline parental concern of overeating also mediated the association between the PRS-BMI and z-BMI at wave 3 (ß = 0.10, 95% CI: 0.07, 0.13) and z-WC at wave 3 (ß = 0.09, 95% CI: 0.07, 0.12). Conclusions: The findings suggest that the prospective associations between obesity indices and parental concern of overeating are likely bi-directional, but obesity indices have a stronger association with future parental concern of overeating than vice versa. The findings suggest parental concern of overeating as a possible mediator in the genetic susceptibility to obesity and further highlight that other pathways are also involved. A better understanding of the genetic pathways that lead to childhood obesity can help to prevent weight gain. Trial registration: Registry number: ISRCTN62310987 Retrospectively registered 17 September 2018. © 2021, The Author(s).
000109713 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000109713 590__ $$a8.915$$b2021
000109713 592__ $$a2.028$$b2021
000109713 594__ $$a10.2$$b2021
000109713 591__ $$aPHYSIOLOGY$$b5 / 81 = 0.062$$c2021$$dQ1$$eT1
000109713 593__ $$aNutrition and Dietetics$$c2021$$dQ1
000109713 591__ $$aNUTRITION & DIETETICS$$b7 / 90 = 0.078$$c2021$$dQ1$$eT1
000109713 593__ $$aMedicine (miscellaneous)$$c2021$$dQ1
000109713 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000109713 700__ $$aForaita, R.
000109713 700__ $$aSilventoinen, K.
000109713 700__ $$aAdan, R.A.H.
000109713 700__ $$aAhrens, W.
000109713 700__ $$aDe Henauw, S.
000109713 700__ $$aHebestreit, A.
000109713 700__ $$aKeski-Rahkonen, A.
000109713 700__ $$aLissner, L.
000109713 700__ $$aMehlig, K.
000109713 700__ $$aMolnar, D.
000109713 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L.A.$$uUniversidad de Zaragoza
000109713 700__ $$aPigeot, I.
000109713 700__ $$aRusso, P.
000109713 700__ $$aVeidebaum, T.
000109713 700__ $$aBogl, L.H.
000109713 700__ $$aKaprio, J.
000109713 700__ $$aon behalf of the IDEFICS/I.Family Consortia
000109713 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000109713 773__ $$g18, 1 (2021), 139 [11 pp]$$pInternational Journal of Behavioral Nutrition and Physical Activity$$tInternational Journal of Behavioral Nutrition and Physical Activity$$x1479-5868
000109713 8564_ $$s1831679$$uhttps://zaguan.unizar.es/record/109713/files/texto_completo.pdf$$yVersión publicada
000109713 8564_ $$s2500034$$uhttps://zaguan.unizar.es/record/109713/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000109713 909CO $$ooai:zaguan.unizar.es:109713$$particulos$$pdriver
000109713 951__ $$a2023-05-18-15:55:47
000109713 980__ $$aARTICLE