000110563 001__ 110563
000110563 005__ 20230519145526.0
000110563 0247_ $$2doi$$a10.3390/ijms222111745
000110563 0248_ $$2sideral$$a127640
000110563 037__ $$aART-2021-127640
000110563 041__ $$aeng
000110563 100__ $$aColón-Mesa, Ignacio
000110563 245__ $$aRegulation of p27 and cdk2 expression in different adipose tissue depots in aging and obesity
000110563 260__ $$c2021
000110563 5060_ $$aAccess copy available to the general public$$fUnrestricted
000110563 5203_ $$aAging usually comes associated with increased visceral fat accumulation, reaching even an obesity state, and favoring its associated comorbidities. One of the processes involved in aging is cellular senescence, which is highly dependent on the activity of the regulators of the cell cycle. The aim of this study was to analyze the changes in the expression of p27 and cdk2 in different adipose tissue depots during aging, as well as their regulation by obesity in mice. Changes in the expression of p27 and CDK2 in visceral and subcutaneous white adipose tissue (WAT) biopsies were also analyzed in a human cohort of obesity and type 2 diabetes. p27, but not cdk2, exhibits a lower expression in subcutaneous than in visceral WAT in mice and humans. p27 is drastically downregulated by aging in subcutaneous WAT (scWAT), but not in gonadal WAT, of female mice. Obesity upregulates p27 and cdk2 expression in scWAT, but not in other fat depots of aged mice. In humans, a significant upregulation of p27 was observed in visceral WAT of subjects with obesity. Taken together, these results show a differential adipose depot-dependent regulation of p27 and cdk2 in aging and obesity, suggesting that p27 and cdk2 could contribute to the adipose-tissue depot’s metabolic differences. Further studies are necessary to fully corroborate this hypothesis.
000110563 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CB12-03-30002$$9info:eu-repo/grantAgreement/ES/MCIU/CER-20191010-TECNOMIFOOD$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/BFU2015-65937-R
000110563 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000110563 590__ $$a6.208$$b2021
000110563 592__ $$a1.176$$b2021
000110563 594__ $$a6.9$$b2021
000110563 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b69 / 297 = 0.232$$c2021$$dQ1$$eT1
000110563 593__ $$aComputer Science Applications$$c2021$$dQ1
000110563 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b50 / 180 = 0.278$$c2021$$dQ2$$eT1
000110563 593__ $$aInorganic Chemistry$$c2021$$dQ1
000110563 593__ $$aSpectroscopy$$c2021$$dQ1
000110563 593__ $$aOrganic Chemistry$$c2021$$dQ1
000110563 593__ $$aPhysical and Theoretical Chemistry$$c2021$$dQ1
000110563 593__ $$aMolecular Biology$$c2021$$dQ1
000110563 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000110563 700__ $$aFernández-Galilea, Marta
000110563 700__ $$aSáinz, Neira
000110563 700__ $$aLopez-Yus, Marta
000110563 700__ $$0(orcid)0000-0003-0437-0028$$aArtigas, Jose M.$$uUniversidad de Zaragoza
000110563 700__ $$aArbonés-Mainar, José Miguel
000110563 700__ $$aFélix-Soriano, Elisa
000110563 700__ $$aEscoté, Xavier
000110563 700__ $$aMoreno-Aliaga, María Jesús
000110563 7102_ $$11011$$2770$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Radiol. y Medicina Física
000110563 773__ $$g22, 21 (2021), 11745 [17 pp.]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000110563 8564_ $$s9700898$$uhttps://zaguan.unizar.es/record/110563/files/texto_completo.pdf$$yVersión publicada
000110563 8564_ $$s2829730$$uhttps://zaguan.unizar.es/record/110563/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000110563 909CO $$ooai:zaguan.unizar.es:110563$$particulos$$pdriver
000110563 951__ $$a2023-05-18-15:26:43
000110563 980__ $$aARTICLE