110576 20240122154815.0 doi 10.3390/ijerph19020876 sideral 127181 ART-2022-127181 eng Lecina, Miguel 768-km Multi-Stage Ultra-Trail Case Study-Muscle Damage, Biochemical Alterations and Strength Loss on Lower Limbs 2022 Access copy available to the general public Unrestricted A series of case studies aimed to evaluate muscular fatigue in running a 768-km ultra-trail race in 11 days. Four non-professional athletes (four males) were enrolled. Muscle damage blood biomarkers (creatine kinase (CK), lactodeshydrogenase (LDH), aspartate transaminase (AST) and alanine aminotransferase (ALT) and lower limb strength were evaluated by using Bosco jumps test; squat jump (SJ), countermovement jump (CMJ) and Abalakov jump (ABA) were assessed before (pre), after the race (post) and for two and nine days during the recovery period (rec2 and rec9), respectively. Results showed: pre-post SJ = −28%, CMJ = −36% and ABA = −21%. Values returned to basal during rec9: SJ = −1%, CMJ = −2% or even exceeded pre-values ABA = +3%. On the contrary, muscle damage blood biomarkers values increased at post; CK = +888%, LDH = +172%, AST = +167% and ALT = +159% and the values returned gradually to baseline at rec9 except for AST = +226% and ALT = +103% which remained higher. Nonparametric bivariate Spearman’s test showed strong correlations (Rs ≥ 0.8) between some jumps and muscle damage biomarkers at post (SJ-LDH Rs = 0.80, SJ-AST Rs = 0.8, ABA-LD H Rs = 0.80 and ABA-AST Rs = 0.80), at rec2 (SJ-CK Rs = 0.80 and SJ-ALT Rs = 0.80) and even during rec9 (ABA-CK). Similarly, some parameters such as accumulated elevation and training volume showed a strong correlation with LDH values after finishing the ultra-trail race. The alteration induced by completing an ultra-trail event in the muscle affects lower limb strength and may in some circumstances result in serious medical conditions including post- exertional rhabdomyolysis. info:eu-repo/grantAgreement/ES/DGA/S53-17D info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 0.828 2022 Health, Toxicology and Mutagenesis 2022 Q2 Public Health, Environmental and Occupational Health 2022 Q2 Pollution 2022 Q2 5.4 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Castellar, Carlos Universidad de Zaragoza (orcid)0000-0003-1121-6408 Pradas, Francisco Universidad de Zaragoza (orcid)0000-0002-6829-0775 López-Laval, Isaac Universidad de Zaragoza (orcid)0000-0002-9304-3709 3001 187 Universidad de Zaragoza Dpto. Expres.Music.Plást.Corp. Área Didáctica Expres.Corporal 1006 245 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Educación Física y Depor. 19, 2 (2022), 876 Int. j. environ. res. public health International journal of environmental research and public health 1661-7827 365770 http://zaguan.unizar.es/record/110576/files/texto_completo.pdf Versión publicada 2826301 http://zaguan.unizar.es/record/110576/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:110576 articulos driver 2024-01-22-15:39:08 ARTICLE