000110609 001__ 110609
000110609 005__ 20240212141706.0
000110609 0247_ $$2doi$$a10.1007/s11606-021-07017-8
000110609 0248_ $$2sideral$$a127550
000110609 037__ $$aART-2021-127550
000110609 041__ $$aeng
000110609 100__ $$aGarcía-Cervera, Carles
000110609 245__ $$aEstimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry
000110609 260__ $$c2021
000110609 5060_ $$aAccess copy available to the general public$$fUnrestricted
000110609 5203_ $$aBackground: Venous thrombotic events (VTE) are frequent in COVID-19, and elevated plasma D-dimer (pDd) and dyspnea are common in both entities. Objective: To determine the admission pDd cut-off value associated with in-hospital VTE in patients with COVID-19. Methods: Multicenter, retrospective study analyzing the at-admission pDd cut-off value to predict VTE and anticoagulation intensity along hospitalization due to COVID-19. Results: Among 9386 patients, 2.2% had VTE: 1.6% pulmonary embolism (PE), 0.4% deep vein thrombosis (DVT), and 0.2% both. Those with VTE had a higher prevalence of tachypnea (42.9% vs. 31.1%; p = 0.0005), basal O2 saturation <93% (45.4% vs. 33.1%; p = 0.0003), higher at admission pDd (median [IQR]: 1.4 [0.6–5.5] vs. 0.6 [0.4–1.2] µg/ml; p < 0.0001) and platelet count (median [IQR]: 208 [158–289] vs. 189 [148–245] platelets × 109/L; p = 0.0013). A pDd cut-off of 1.1 µg/ml showed specificity 72%, sensitivity 49%, positive predictive value (PPV) 4%, and negative predictive value (NPV) 99% for in-hospital VTE. A cut-off value of 4.7 µg/ml showed specificity of 95%, sensitivity of 27%, PPV of 9%, and NPV of 98%. Overall mortality was proportional to pDd value, with the lowest incidence for each pDd category depending on anticoagulation intensity: 26.3% for those with pDd >1.0 µg/ml treated with prophylactic dose (p < 0.0001), 28.8% for pDd for patients with pDd >2.0 µg/ml treated with intermediate dose (p = 0.0001), and 31.3% for those with pDd >3.0 µg/ml and full anticoagulation (p = 0.0183). Conclusions: In hospitalized patients with COVID-19, a pDd value greater than 3.0 µg/ml can be considered to screen VTE and to consider full-dose anticoagulation. © 2021, Society of General Internal Medicine.
000110609 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000110609 590__ $$a6.473$$b2021
000110609 592__ $$a1.537$$b2021
000110609 594__ $$a5.7$$b2021
000110609 591__ $$aMEDICINE, GENERAL & INTERNAL$$b31 / 172 = 0.18$$c2021$$dQ1$$eT1
000110609 593__ $$aInternal Medicine$$c2021$$dQ1
000110609 591__ $$aHEALTH CARE SCIENCES & SERVICES$$b11 / 109 = 0.101$$c2021$$dQ1$$eT1
000110609 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000110609 700__ $$aGiner-Galvañ, Vicente
000110609 700__ $$aWikman-Jorgensen, Philip
000110609 700__ $$aLaureiro, Jaime
000110609 700__ $$aRubio-Rivas, Manuel
000110609 700__ $$aGurjian Arena, Anthony
000110609 700__ $$aArnalich-Fernandez, Francisco
000110609 700__ $$aBeato Pérez, José Luis
000110609 700__ $$aVargas Núñez, Juan Antonio
000110609 700__ $$aGonzález Igual, Jesús Javier$$uUniversidad de Zaragoza
000110609 700__ $$0(orcid)0000-0002-3132-2171$$aDíez-Manglano, Jesús$$uUniversidad de Zaragoza
000110609 700__ $$aMéndez Bailón, Manuel
000110609 700__ $$aGarcía Blanco, María José
000110609 700__ $$aFreire Castro, Santiago J.
000110609 700__ $$aAranda Lobo, Judit
000110609 700__ $$aManzano, Luis
000110609 700__ $$aMagallanes Gamboa, Jeffrey Oskar
000110609 700__ $$aArribas Pérez, Luis
000110609 700__ $$aGonzález Moraleja, Julio
000110609 700__ $$aCalderón Hernaiz, Ruth
000110609 700__ $$aGarcía Alegría, Javier
000110609 700__ $$aGonzález Noya, Amara
000110609 700__ $$aGómez Huelgas, Ricardo
000110609 700__ $$aLumbreras Bermejo, Carlos
000110609 700__ $$aAntón Santos, Juan Miguel
000110609 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000110609 773__ $$g36, 11 (2021), 3478-3486$$pJ. gen. intern. med.$$tJOURNAL OF GENERAL INTERNAL MEDICINE$$x0884-8734
000110609 8564_ $$s422398$$uhttps://zaguan.unizar.es/record/110609/files/texto_completo.pdf$$yVersión publicada
000110609 8564_ $$s2976110$$uhttps://zaguan.unizar.es/record/110609/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000110609 909CO $$ooai:zaguan.unizar.es:110609$$particulos$$pdriver
000110609 951__ $$a2024-02-12-14:15:26
000110609 980__ $$aARTICLE