000110610 001__ 110610
000110610 005__ 20230519145619.0
000110610 0247_ $$2doi$$a10.1016/j.surg.2021.04.023
000110610 0248_ $$2sideral$$a127551
000110610 037__ $$aART-2021-127551
000110610 041__ $$aeng
000110610 100__ $$aProbst P.
000110610 245__ $$aEvidence Map of Pancreatic Surgery–A living systematic review with meta-analyses by the International Study Group of Pancreatic Surgery (ISGPS)
000110610 260__ $$c2021
000110610 5060_ $$aAccess copy available to the general public$$fUnrestricted
000110610 5203_ $$aBackground: Pancreatic surgery is associated with considerable morbidity and, consequently, offers a large and complex field for research. To prioritize relevant future scientific projects, it is of utmost importance to identify existing evidence and uncover research gaps. Thus, the aim of this project was to create a systematic and living Evidence Map of Pancreatic Surgery. Methods: PubMed, the Cochrane Central Register of Controlled Trials, and Web of Science were systematically searched for all randomized controlled trials and systematic reviews on pancreatic surgery. Outcomes from every existing randomized controlled trial were extracted, and trial quality was assessed. Systematic reviews were used to identify an absence of randomized controlled trials. Randomized controlled trials and systematic reviews on identical subjects were grouped according to research topics. A web-based evidence map modeled after a mind map was created to visualize existing evidence. Meta-analyses of specific outcomes of pancreatic surgery were performed for all research topics with more than 3 randomized controlled trials. For partial pancreatoduodenectomy and distal pancreatectomy, pooled benchmarks for outcomes were calculated with a 99% confidence interval. The evidence map undergoes regular updates. Results: Out of 30, 860 articles reviewed, 328 randomized controlled trials on 35, 600 patients and 332 systematic reviews were included and grouped into 76 research topics. Most randomized controlled trials were from Europe (46%) and most systematic reviews were from Asia (51%). A living meta-analysis of 21 out of 76 research topics (28%) was performed and included in the web-based evidence map. Evidence gaps were identified in 11 out of 76 research topics (14%). The benchmark for mortality was 2% (99% confidence interval: 1%–2%) for partial pancreatoduodenectomy and <1% (99% confidence interval: 0%–1%) for distal pancreatectomy. The benchmark for overall complications was 53% (99%confidence interval: 46%–61%) for partial pancreatoduodenectomy and 59% (99% confidence interval: 44%–80%) for distal pancreatectomy. Conclusion: The International Study Group of Pancreatic Surgery Evidence Map of Pancreatic Surgery, which is freely accessible via www.evidencemap.surgery and as a mobile phone app, provides a regularly updated overview of the available literature displayed in an intuitive fashion. Clinical decision making and evidence-based patient information are supported by the primary data provided, as well as by living meta-analyses. Researchers can use the systematic literature search and processed data for their own projects, and funding bodies can base their research priorities on evidence gaps that the map uncovers. © 2021 The Authors
000110610 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000110610 590__ $$a4.348$$b2021
000110610 592__ $$a1.236$$b2021
000110610 594__ $$a5.5$$b2021
000110610 591__ $$aSURGERY$$b36 / 214 = 0.168$$c2021$$dQ1$$eT1
000110610 593__ $$aSurgery$$c2021$$dQ1
000110610 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000110610 700__ $$aHüttner F.J.
000110610 700__ $$aMeydan Ö.
000110610 700__ $$aAbu Hilal M.
000110610 700__ $$aAdham M.
000110610 700__ $$aBarreto S.G.
000110610 700__ $$aBesselink M.G.
000110610 700__ $$aBusch O.R.
000110610 700__ $$aBockhorn M.
000110610 700__ $$aDel Chiaro M.
000110610 700__ $$aConlon K.
000110610 700__ $$aCastillo C.F.-D.
000110610 700__ $$aFriess H.
000110610 700__ $$aFusai G.K.
000110610 700__ $$aGianotti L.
000110610 700__ $$aHackert T.
000110610 700__ $$aHalloran C.
000110610 700__ $$aIzbicki J.
000110610 700__ $$aKalkum E.
000110610 700__ $$aKelemen D.
000110610 700__ $$aKenngott H.G.
000110610 700__ $$aKretschmer R.
000110610 700__ $$aLandré V.
000110610 700__ $$aLillemoe K.D.
000110610 700__ $$aMiao Y.
000110610 700__ $$aMarchegiani G.
000110610 700__ $$aMihaljevic A.
000110610 700__ $$aRadenkovic D.
000110610 700__ $$aSalvia R.
000110610 700__ $$aSandini M.
000110610 700__ $$0(orcid)0000-0003-4712-9891$$aSerrablo Requejo, A.$$uUniversidad de Zaragoza
000110610 700__ $$aShrikhande S.
000110610 700__ $$aShukla P.J.
000110610 700__ $$aSiriwardena A.K.
000110610 700__ $$aStrobel O.
000110610 700__ $$aUzunoglu F.G.
000110610 700__ $$aVollmer C.
000110610 700__ $$aWeitz J.
000110610 700__ $$aWolfgang C.L.
000110610 700__ $$aZerbi A.
000110610 700__ $$aBassi C.
000110610 700__ $$aDervenis C.
000110610 700__ $$aNeoptolemos J.
000110610 700__ $$aBüchler M.W.
000110610 700__ $$aDiener M.K.
000110610 7102_ $$11013$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Cirugía
000110610 773__ $$g170, 5 (2021), 1517-1524$$pSurgery$$tSURGERY$$x0039-6060
000110610 8564_ $$s571489$$uhttps://zaguan.unizar.es/record/110610/files/texto_completo.pdf$$yVersión publicada
000110610 8564_ $$s2496218$$uhttps://zaguan.unizar.es/record/110610/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000110610 909CO $$ooai:zaguan.unizar.es:110610$$particulos$$pdriver
000110610 951__ $$a2023-05-18-16:13:55
000110610 980__ $$aARTICLE