Trajectories of alcohol consumption during life and the risk of developing breast cancer

Donat-Vargas C. ; Guerrero-Zotano Á. ; Casas A. ; Baena-Cañada J.M. ; Lope V. ; Antolín S. ; Garcia-Saénz J.Á. ; Bermejo B. ; Muñoz M. ; Ramos M. ; de Juan A. ; Jara Sánchez C. ; Sánchez-Rovira P. ; Antón Torres, A. (Universidad de Zaragoza) ; Brunet J. ; Gavilá J. ; Salvador J. ; Arriola Arellano E. ; Bezares S. ; Fernández de Larrea-Baz N. ; Pérez-Gómez B. ; Martín M. ; Pollán M.

Resumen: Background: Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive. Objective: To compare the influence of distinctive trajectories of alcohol consumption throughout a woman’s life on development of breast cancer (BC). Methods: 1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women’s lifetime. Results: Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption (<5 g/day) throughout their life. The second included those (33%) who gradually moved from a low alcohol consumption in adolescence to a moderate in adulthood (5 to <15 g/day), never having a high consumption; and oppositely, women in the third trajectory (16%) moved from moderate consumption in adolescence, to a lower consumption in adulthood. Women in the fourth (6%) moved from a moderate alcohol consumption in adolescence to the highest consumption in adulthood (=15 g/day), never having a low alcohol consumption. Comparing with the first trajectory, the fourth doubled BC risk (OR 2.19; 95% CI 1.27, 3.77), followed by the third (OR 1.44; 0.96, 2.16) and ultimately by the second trajectory (OR 1.17; 0.86, 1.58). The magnitude of BC risk was greater in postmenopausal women, especially in those with underweight or normal weight. When alcohol consumption was independently examined at each life stage, =15 g/day of alcohol consumption in adolescence was strongly associated with BC risk followed by consumption in adulthood. Conclusions: The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk. © 2021, The Author(s).

Idioma: Inglés

DOI: 10.1038/s41416-021-01492-w

Año: 2021

Publicado en: BRITISH JOURNAL OF CANCER 125, 8 (2021), 1168-1176
ISSN: 0007-0920

Factor impacto JCR: 9.082 (2021)

Categ. JCR: ONCOLOGY rank: 37 / 245 = 0.151 (2021) - Q1 - T1

Factor impacto CITESCORE: 12.4 - Medicine (Q1) - Biochemistry, Genetics and Molecular Biology (Q1)

Factor impacto SCIMAGO: 2.272 - Oncology (Q1) - Cancer Research (Q1)

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)