000110627 001__ 110627
000110627 005__ 20240319081002.0
000110627 0247_ $$2doi$$a10.3389/fvets.2021.805004
000110627 0248_ $$2sideral$$a127501
000110627 037__ $$aART-2022-127501
000110627 041__ $$aeng
000110627 100__ $$0(orcid)0000-0002-7173-7216$$aBadiola, J. J.$$uUniversidad de Zaragoza
000110627 245__ $$aSARS-CoV-2 outbreak on a Spanish mink farm: epidemiological, molecular, and pathological studies
000110627 260__ $$c2022
000110627 5060_ $$aAccess copy available to the general public$$fUnrestricted
000110627 5203_ $$aFarmed minks have been reported to be highly susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and may represent a risk to humans. In this study, we describe the first outbreak of SARS-CoV-2 occurred on a mink farm in Spain, between June and July 2020, involving 92,700 animals. The outbreak started shortly after some farm workers became seropositive for SARS-CoV-2. Minks showed no clinical signs compatible with SARS-CoV-2 infection throughout the outbreak. Samples from 98 minks were collected for histopathological, serological, and molecular studies. Twenty out of 98 (20.4%) minks were positive by RT-qPCR and 82 out 92 (89%) seroconverted. This finding may reflect a rapid spread of the virus at the farm with most of the animals overcoming the infection. Additionally, SARS-CoV-2 was detected by RT-qPCR in 30% of brain samples from positive minks. Sequencing analysis showed that the mink sequences were not closely related with the other mink SARS-CoV-2 sequences available, and that this mink outbreak has its probable origin in one of the genetic variants that were prevalent in Spain during the first COVID-19 epidemic wave. Histological studies revealed bronchointerstitial pneumonia in some animals. Immunostaining of viral nucleocapsid was also observed in nasal turbinate tissue. Farmed minks could therefore constitute an important SARS-CoV-2 reservoir, contributing to virus spread among minks and humans. Consequently, continuous surveillance of mink farms is needed.
000110627 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/COV20-00140
000110627 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000110627 590__ $$a3.2$$b2022
000110627 592__ $$a0.737$$b2022
000110627 591__ $$aVETERINARY SCIENCES$$b12 / 144 = 0.083$$c2022$$dQ1$$eT1
000110627 593__ $$aVeterinary (miscellaneous)$$c2022$$dQ1
000110627 594__ $$a3.8$$b2022
000110627 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000110627 700__ $$0(orcid)0000-0001-9075-2764$$aOtero, A.$$uUniversidad de Zaragoza
000110627 700__ $$0(orcid)0000-0002-4213-2904$$aSevilla, E.$$uUniversidad de Zaragoza
000110627 700__ $$0(orcid)0000-0002-1590-3347$$aMarín, B.$$uUniversidad de Zaragoza
000110627 700__ $$0(orcid)0000-0002-8752-5146$$aGarcía Martínez, M.$$uUniversidad de Zaragoza
000110627 700__ $$0(orcid)0000-0002-0388-9429$$aBetancor, M.$$uUniversidad de Zaragoza
000110627 700__ $$aSola, D.$$uUniversidad de Zaragoza
000110627 700__ $$0(orcid)0000-0002-2079-0711$$aPérez Lázaro, S.$$uUniversidad de Zaragoza
000110627 700__ $$aLozada, J.
000110627 700__ $$aVelez, C.
000110627 700__ $$aChiner-Oms, Á.
000110627 700__ $$aComas, I.
000110627 700__ $$aCancino-Muñoz, I.
000110627 700__ $$0(orcid)0000-0002-7453-1766$$aMonleón, E$$uUniversidad de Zaragoza
000110627 700__ $$0(orcid)0000-0002-2787-9671$$aMonzón, M.$$uUniversidad de Zaragoza
000110627 700__ $$0(orcid)0000-0001-5105-6133$$aAcín, C.$$uUniversidad de Zaragoza
000110627 700__ $$0(orcid)0000-0002-2746-3932$$aBolea, R.$$uUniversidad de Zaragoza
000110627 700__ $$0(orcid)0000-0001-6629-6842$$aMoreno, B.$$uUniversidad de Zaragoza
000110627 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000110627 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000110627 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000110627 773__ $$g8 (2022), 805004[9 pp.]$$pFront. vet. sci.$$tFrontiers in Veterinary Science$$x2297-1769
000110627 8564_ $$s1337713$$uhttps://zaguan.unizar.es/record/110627/files/texto_completo.pdf$$yVersión publicada
000110627 8564_ $$s2426718$$uhttps://zaguan.unizar.es/record/110627/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000110627 909CO $$ooai:zaguan.unizar.es:110627$$particulos$$pdriver
000110627 951__ $$a2024-03-18-14:14:51
000110627 980__ $$aARTICLE