000110641 001__ 110641
000110641 005__ 20230519145410.0
000110641 0247_ $$2doi$$a10.1016/j.joca.2021.05.055
000110641 0248_ $$2sideral$$a125051
000110641 037__ $$aART-2021-125051
000110641 041__ $$aeng
000110641 100__ $$aPaesa, M.
000110641 245__ $$aTherapeutic molecules for osteoarthritis treatment. role of phloretin, ipriflavone and raloxifene in lipopolysaccharide induced osteoarthritic chondrocytes
000110641 260__ $$c2021
000110641 5060_ $$aAccess copy available to the general public$$fUnrestricted
000110641 5203_ $$aPurpose: The search of novel molecules for the treatment of osteoarthritis (OA) is complex as any new therapeutic approach should encompass these requirements: inhibition of cartilage degradation, protection of bone and inhibition of inflammation. In the last years, different drugs have been proposed though most of them did not succeed in fulfil these requirements. Moreover, few of them have been encapsulated in drug delivery systems to improve their therapeutic potential to achieve a sustained or controlled release compared to the administration of equivalent doses of the free compounds. Nanoscience has arisen in the last decades as a potential field of study in drug delivery because nanomaterials may overcome the main current limitations to achieve an efficient and localized drug delivery by improving the targeted delivery and providing a sustained or controlled delivery to prolong the therapeutic effect. On the other hand, different polyphenols and aromatic organic compounds are known to possess anti-inflammatory, antioxidant and bone density-building properties...
000110641 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000110641 590__ $$a7.507$$b2021
000110641 592__ $$a1.823$$b2021
000110641 594__ $$a10.2$$b2021
000110641 591__ $$aRHEUMATOLOGY$$b5 / 34 = 0.147$$c2021$$dQ1$$eT1
000110641 593__ $$aOrthopedics and Sports Medicine$$c2021$$dQ1
000110641 591__ $$aORTHOPEDICS$$b2 / 86 = 0.023$$c2021$$dQ1$$eT1
000110641 593__ $$aBiomedical Engineering$$c2021$$dQ1
000110641 655_4 $$ainfo:eu-repo/semantics/conferenceObject$$vinfo:eu-repo/semantics/publishedVersion
000110641 700__ $$aRemirez de Ganuza, C.
000110641 700__ $$aBertol, J.
000110641 700__ $$0(orcid)0000-0003-2587-7506$$aGarcía-Alvarez, F.$$uUniversidad de Zaragoza
000110641 700__ $$0(orcid)0000-0002-3595-7668$$aRodriguez Yoldi, M.$$uUniversidad de Zaragoza
000110641 700__ $$0(orcid)0000-0002-2966-9088$$aIrusta, S.$$uUniversidad de Zaragoza
000110641 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, M.$$uUniversidad de Zaragoza
000110641 700__ $$aMendoza, G.
000110641 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000110641 7102_ $$11013$$2830$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Traumatología y Ortopedia
000110641 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000110641 7102_ $$15005$$2790$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Tecnologi. Medio Ambiente
000110641 773__ $$g29, SUPP 2 (2021), S33-S35$$pOsteoarthr. cartil.$$tOSTEOARTHRITIS AND CARTILAGE$$x1063-4584
000110641 8564_ $$s831980$$uhttps://zaguan.unizar.es/record/110641/files/texto_completo.pdf$$yVersión publicada
000110641 8564_ $$s4218896$$uhttps://zaguan.unizar.es/record/110641/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000110641 909CO $$ooai:zaguan.unizar.es:110641$$particulos$$pdriver
000110641 951__ $$a2023-05-18-13:54:32
000110641 980__ $$aARTICLE