110641 20230519145410.0 doi 10.1016/j.joca.2021.05.055 sideral 125051 ART-2021-125051 eng Paesa, M. Therapeutic molecules for osteoarthritis treatment. role of phloretin, ipriflavone and raloxifene in lipopolysaccharide induced osteoarthritic chondrocytes 2021 Access copy available to the general public Unrestricted Purpose: The search of novel molecules for the treatment of osteoarthritis (OA) is complex as any new therapeutic approach should encompass these requirements: inhibition of cartilage degradation, protection of bone and inhibition of inflammation. In the last years, different drugs have been proposed though most of them did not succeed in fulfil these requirements. Moreover, few of them have been encapsulated in drug delivery systems to improve their therapeutic potential to achieve a sustained or controlled release compared to the administration of equivalent doses of the free compounds. Nanoscience has arisen in the last decades as a potential field of study in drug delivery because nanomaterials may overcome the main current limitations to achieve an efficient and localized drug delivery by improving the targeted delivery and providing a sustained or controlled delivery to prolong the therapeutic effect. On the other hand, different polyphenols and aromatic organic compounds are known to possess anti-inflammatory, antioxidant and bone density-building properties... info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 7.507 2021 RHEUMATOLOGY 5 / 34 = 0.147 2021 Q1 T1 ORTHOPEDICS 2 / 86 = 0.023 2021 Q1 T1 1.823 2021 Orthopedics and Sports Medicine 2021 Q1 Biomedical Engineering 2021 Q1 10.2 2021 info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/publishedVersion Remirez de Ganuza, C. Bertol, J. García-Alvarez, F. Universidad de Zaragoza (orcid)0000-0003-2587-7506 Rodriguez Yoldi, M. Universidad de Zaragoza (orcid)0000-0002-3595-7668 Irusta, S. Universidad de Zaragoza (orcid)0000-0002-2966-9088 Arruebo, M. Universidad de Zaragoza (orcid)0000-0003-3165-0156 Mendoza, G. 1012 410 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Fisiología 1013 830 Universidad de Zaragoza Dpto. Cirugía Área Traumatología y Ortopedia 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 5005 790 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Tecnologi. Medio Ambiente 29, SUPP 2 (2021), S33-S35 Osteoarthr. cartil. OSTEOARTHRITIS AND CARTILAGE 1063-4584 831980 http://zaguan.unizar.es/record/110641/files/texto_completo.pdf Versión publicada 4218896 http://zaguan.unizar.es/record/110641/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:110641 articulos driver 2023-05-18-13:54:32 ARTICLE