000110689 001__ 110689
000110689 005__ 20230519145600.0
000110689 0247_ $$2doi$$a10.1038/s41598-021-89511-x
000110689 0248_ $$2sideral$$a126805
000110689 037__ $$aART-2021-126805
000110689 041__ $$aeng
000110689 100__ $$aComín, J.
000110689 245__ $$aAnalysis of Mycobacterium africanum in the last 17 years in Aragon identifies a specific location of IS6110 in Lineage 6
000110689 260__ $$c2021
000110689 5060_ $$aAccess copy available to the general public$$fUnrestricted
000110689 5203_ $$aThe purpose of this study was to increase our knowledge about Mycobacterium africanum and report the incidence and characteristics of tuberculosis (TB) due to their lineages in Aragon, Spain, over the period 2003–2019. The study includes all the cases in our region, where all the M. tuberculosis complex isolates are systematically characterised. We detected 31 cases of M. africanum among 2598 cases of TB in the period studied. TB caused by M. africanum is rare (1.19%) in our population, and it affects mainly men of economically productive age coming from West African countries. Among the isolates, Lineage (L) 6 was more frequent than L5. The genotyping of these strains identified five clusters and 13 strains with a unique pattern. The isolates’ characterisation identified a copy of IS6110 within the moaX gene, which turned out to be specific for L6. It will allow the differentiation of this lineage from the rest of MTBC with a simple PCR reaction. It remains to be established whether this polymorphism may limit M. africanum transmission. Furthermore, a mutation in the mutT2 promoter was found as specific for L6 strains, which could be related to the high variability found for L6 compared to L5. © 2021, The Author(s).
000110689 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS18-0336
000110689 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000110689 590__ $$a4.997$$b2021
000110689 592__ $$a1.005$$b2021
000110689 591__ $$aMULTIDISCIPLINARY SCIENCES$$b19 / 74 = 0.257$$c2021$$dQ2$$eT1
000110689 593__ $$aMultidisciplinary$$c2021$$dQ1
000110689 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000110689 700__ $$aMonforte, M.L.
000110689 700__ $$aSamper, S.
000110689 700__ $$0(orcid)0000-0003-2266-8602$$aIglesias, M.J.$$uUniversidad de Zaragoza
000110689 700__ $$aIbarz, D.$$uUniversidad de Zaragoza
000110689 700__ $$aViñuelas, J.
000110689 700__ $$aTorres, L.
000110689 700__ $$aSahagún, J.
000110689 700__ $$aLafoz, M.C.
000110689 700__ $$aMalo, M.C.
000110689 700__ $$0(orcid)0000-0003-1027-7583$$aOtal, I.$$uUniversidad de Zaragoza
000110689 700__ $$aAragonese Working Group on Molecular Epidemiology of Tuberculosis (EPIMOLA)
000110689 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000110689 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000110689 773__ $$g11, 1 (2021), 10359 [10 pp]$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000110689 8564_ $$s1441302$$uhttps://zaguan.unizar.es/record/110689/files/texto_completo.pdf$$yVersión publicada
000110689 8564_ $$s2584675$$uhttps://zaguan.unizar.es/record/110689/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000110689 909CO $$ooai:zaguan.unizar.es:110689$$particulos$$pdriver
000110689 951__ $$a2023-05-18-15:59:40
000110689 980__ $$aARTICLE