000110692 001__ 110692 000110692 005__ 20230519145603.0 000110692 0247_ $$2doi$$a10.1371/journal.pone.0259822 000110692 0248_ $$2sideral$$a127216 000110692 037__ $$aART-2021-127216 000110692 041__ $$aeng 000110692 100__ $$aGimeno-Miguel, A. 000110692 245__ $$aChronic diseases associated with increased likelihood of hospitalization and mortality in 68, 913 COVID-19 confirmed cases in Spain: A population-based cohort study 000110692 260__ $$c2021 000110692 5060_ $$aAccess copy available to the general public$$fUnrestricted 000110692 5203_ $$aBackground Clinical outcomes among COVID-19 patients vary greatly with age and underlying comorbidities. We aimed to determine the demographic and clinical factors, particularly baseline chronic conditions, associated with an increased risk of severity in COVID-19 patients from a population-based perspective and using data from electronic health records (EHR). Methods Retrospective, observational study in an open cohort analyzing all 68, 913 individuals (mean age 44.4 years, 53.2% women) with SARS-CoV-2 infection between 15 June and 19 December 2020 using exhaustive electronic health registries. Patients were followed for 30 days from inclusion or until the date of death within that period. We performed multivariate logistic regression to analyze the association between each chronic disease and severe infection, based on hospitalization and all-cause mortality. Results 5885 (8.5%) individuals showed severe infection and old age was the most influencing factor. Congestive heart failure (odds ratio -OR- men: 1.28, OR women: 1.39), diabetes (1.37, 1.24), chronic renal failure (1.31, 1.22) and obesity (1.21, 1.26) increased the likelihood of severe infection in both sexes. Chronic skin ulcers (1.32), acute cerebrovascular disease (1.34), chronic obstructive pulmonary disease (1.21), urinary incontinence (1.17) and neoplasms (1.26) in men, and infertility (1.87), obstructive sleep apnea (1.43), hepatic steatosis (1.43), rheumatoid arthritis (1.39) and menstrual disorders (1.18) in women were also associated with more severe outcomes. Conclusions Age and specific cardiovascular and metabolic diseases increased the risk of severe SARSCoV-2 infections in men and women, whereas the effects of certain comorbidities are sex specific. Future studies in different settings are encouraged to analyze which profiles of chronic patients are at higher risk of poor prognosis and should therefore be the targets of prevention and shielding strategies. © 2021 Gimeno-Miguel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 000110692 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/B01-20R 000110692 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000110692 590__ $$a3.752$$b2021 000110692 592__ $$a0.852$$b2021 000110692 591__ $$aMULTIDISCIPLINARY SCIENCES$$b29 / 74 = 0.392$$c2021$$dQ2$$eT2 000110692 593__ $$aMultidisciplinary$$c2021$$dQ1 000110692 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000110692 700__ $$aBliek-Bueno, K. 000110692 700__ $$aPoblador-Plou, B. 000110692 700__ $$aCarmona-Pírez, J. 000110692 700__ $$aPoncel-Falcó, A. 000110692 700__ $$aGonzález-Rubio, F. 000110692 700__ $$aIoakeim-Skoufa, I. 000110692 700__ $$aPico-Soler, V. 000110692 700__ $$aAza-Pascual-Salcedo, M. 000110692 700__ $$aPrados-Torres, A. 000110692 700__ $$0(orcid)0000-0003-2928-6623$$aGimeno-Feliu, L.A.$$uUniversidad de Zaragoza 000110692 700__ $$aGimeno-Miguel, A. 000110692 700__ $$aMoreno-Juste, A. 000110692 700__ $$aCano-Del-Pozo, M. 000110692 700__ $$aBandrés-Liso, A.C. 000110692 700__ $$aDíez-Manglano, J. 000110692 700__ $$aAra-Bardají, P. 000110692 700__ $$athe PRECOVID Group 000110692 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000110692 773__ $$g16, 11 November (2021), e0259822 [14 pp]$$pPLoS One$$tPLoS ONE$$x1932-6203 000110692 8564_ $$s618036$$uhttps://zaguan.unizar.es/record/110692/files/texto_completo.pdf$$yVersión publicada 000110692 8564_ $$s2395025$$uhttps://zaguan.unizar.es/record/110692/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000110692 909CO $$ooai:zaguan.unizar.es:110692$$particulos$$pdriver 000110692 951__ $$a2023-05-18-16:02:04 000110692 980__ $$aARTICLE