000110710 001__ 110710
000110710 005__ 20240319080958.0
000110710 0247_ $$2doi$$a10.1038/s41430-021-00985-4
000110710 0248_ $$2sideral$$a127340
000110710 037__ $$aART-2022-127340
000110710 041__ $$aeng
000110710 100__ $$aWolters, M.
000110710 245__ $$a25-Hydroxyvitamin D reference percentiles and the role of their determinants among European children and adolescents
000110710 260__ $$c2022
000110710 5060_ $$aAccess copy available to the general public$$fUnrestricted
000110710 5203_ $$aBackground/objectives: To provide age- and sex-specific percentile curves of serum 25-hydroxyvitamin D (25(OH)D) by determinants from 3-<15 year-old European children, and to analyse how modifiable determinants influence 25(OH)D. Subjects/methods: Serum samples were collected from children of eight European countries participating in the multicenter IDEFICS/I.Family cohort studies. Serum 25(OH)D concentrations were analysed in a central lab by a chemiluminescence assay and the values from 2171 children (N = 3606 measurements) were used to estimate percentile curves using the generalized additive model for location, scale and shape. The association of 25(OH)D with time spent outdoors was investigated considering sex, age, country, parental education, BMI z score, UV radiation, and dietary vitamin D in regressions models. Results: The age- and sex-specific 5th and 95th percentiles of 25(OH)D ranged from 16.5 to 73.3 and 20.8 to 79.3 nmol/l in girls and boys, respectively. A total of 63% had deficient (<50 nmol/l), 33% insufficient (50-<75 nmol/l) and 3% sufficient (=75 nmol/l) levels. 25(OH)D increased with increasing UV radiation, time spent outdoors, and vitamin D intake and slightly decreased with increasing BMI z score and age. The odds ratio (OR) for a non-deficient 25(OH)D status (reference category: deficient status) by one additional hour spent outdoors was 1.21, 95% CI [1.12–1.31], i.e., children who spent one more hour per day outdoors than other children had a 21% higher chance of a non-deficient than a deficient status. Conclusion: A majority of children suffer from deficient 25(OH)D. UV radiation, outdoor time, and dietary vitamin D are important determinants of 25(OH)D. © 2021, The Author(s).
000110710 536__ $$9info:eu-repo/grantAgreement/EUR/FP6/FOOD-016181$$9info:eu-repo/grantAgreement/EC/FP7/266044/EU/Determinants of eating behaviour in European children, adolescents and their parents/I.FAMILY
000110710 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000110710 590__ $$a4.7$$b2022
000110710 592__ $$a1.073$$b2022
000110710 591__ $$aNUTRITION & DIETETICS$$b33 / 87 = 0.379$$c2022$$dQ2$$eT2
000110710 593__ $$aNutrition and Dietetics$$c2022$$dQ1
000110710 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1
000110710 594__ $$a9.0$$b2022
000110710 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000110710 700__ $$aIntemann, T.
000110710 700__ $$aRusso, P.
000110710 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, L. A.$$uUniversidad de Zaragoza
000110710 700__ $$aMolnár, D.
000110710 700__ $$aVeidebaum, T.
000110710 700__ $$aTornaritis, M.
000110710 700__ $$aDe Henauw, S.
000110710 700__ $$aEiben, G.
000110710 700__ $$aAhrens, W.
000110710 700__ $$aFloegel, A.
000110710 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000110710 773__ $$g76 (2022), 564–573$$pEur. j. clin. nutr.$$tEuropean Journal of Clinical Nutrition$$x0954-3007
000110710 8564_ $$s1164232$$uhttps://zaguan.unizar.es/record/110710/files/texto_completo.pdf$$yVersión publicada
000110710 8564_ $$s2808714$$uhttps://zaguan.unizar.es/record/110710/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000110710 909CO $$ooai:zaguan.unizar.es:110710$$particulos$$pdriver
000110710 951__ $$a2024-03-18-13:48:50
000110710 980__ $$aARTICLE