110736 20230519145623.0 doi 10.3390/biomedicines9111729 sideral 127209 ART-2021-127209 eng Sanz, L. Antibody-based immunotoxins for colorectal cancer therapy 2021 Access copy available to the general public Unrestricted Monoclonal antibodies (mAbs) are included among the treatment options for advanced colorectal cancer (CRC). However, while these mAbs effectively target cancer cells, they may have limited clinical activity. A strategy to improve their therapeutic potential is arming them with a toxic payload. Immunotoxins (ITX) combining the cell-killing ability of a toxin with the specificity of a mAb constitute a promising strategy for CRC therapy. However, several important challenges in optimizing ITX remain, including suboptimal pharmacokinetics and especially the immunogenicity of the toxin moiety. Nonetheless, ongoing research is working to solve these limitations and expand CRC patients’ therapeutic armory. In this review, we provide a comprehensive overview of targets and toxins employed in the design of ITX for CRC and highlight a wide selection of ITX tested in CRC patients as well as preclinical candidates. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. info:eu-repo/grantAgreement/ES/DGA/B31-20R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.757 2021 BIOCHEMISTRY & MOLECULAR BIOLOGY 121 / 297 = 0.407 2021 Q2 T2 PHARMACOLOGY & PHARMACY 87 / 279 = 0.312 2021 Q2 T1 MEDICINE, RESEARCH & EXPERIMENTAL 62 / 140 = 0.443 2021 Q2 T2 0.874 2021 Medicine (miscellaneous) 2021 Q1 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2021 Q1 3.0 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Ibáñez-Pérez, R. Universidad de Zaragoza Guerrero-Ochoa, P. Universidad de Zaragoza (orcid)0000-0002-1657-4792 Lacadena, J. Anel, A. Universidad de Zaragoza (orcid)0000-0002-5175-8394 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 1002 050 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Biología Celular 9, 11 (2021), 1729 [24 pp] Biomedicines 2227-9059 1022053 http://zaguan.unizar.es/record/110736/files/texto_completo.pdf Versión publicada 2773497 http://zaguan.unizar.es/record/110736/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:110736 articulos driver 2023-05-18-16:17:20 ARTICLE