Spread of a SARS-CoV-2 variant through Europe in the summer of 2020.

Hodcroft E.B.; Muñoz P.; Tubio J.M.C.; Milagro A.; Robles-Fonseca L.; Galán-Sanchez F.; Muñoz-Cuevas C.; Moncunill G.; Alvarez-Argüelles M.E.; López-Hontangas J.L.; Zuber M.; Navero-Castillejos J.; Eliecer-Cano M.; Veesler D.; Moreno-Docón A.; Torregrosa-Hetland C.J.; Sicilia J.; Peiró-Mestres A.; Bueno J.; Dobaño C.; Rodríguez-Castro J.; Gallego-García P.; Camarena J.J.; Gimeno-Cardona C.; Molina A.J.; González Barberá E.M.; Viñuela-González L.; Valverde D.; Oliver A.; Martínez-Macias O.; Canut-Blasco A.; Reichmuth M.L.; García-González N.; González-Cantó J.; Fuster-Escrivá B.; Carbó-Ramírez S.; Escudero M.B.; Crawford K.H.D.; Martín-Sánchez V.; Cordón M.L.A.; Vila J.; Palop-Borrás B.; Fernández-Pinero J.; Comas I.; Soriano A.; Pérez-Ruiz M.; Sanchez-Almendro J.; Posada D.; Galiana A.; González-Recio Ó.; Pedrosa-Corral I.; Algarate S.; Hernando A.; Montes M.; López-Causapé C.; Bracho M.A.; Cascales-Ramos P.; Rezusta A.; Argüello H.; Barbeito-Castiñeiras G.; Farga-Martí M.A.; Boga J.A.; García F.; Fernández-Villa T.; Lecároz-Agara M.-C.; Gomez-Ruiz M.D.; Rubio E.; Rabella N.; Gozalo-Margüello M.; Cisteró P.; López M.G.; de Toro M.; Planas A.M.; Viedma E.; Fernandez-Silva I.; Ruiz-Hueso P.; Mayor A.; Sanbonmatsu-Gámez S.; Lozano-Serra J.; Cancino-Muñoz I.; Sanmartín I.; Mediavilla-Gradolph M.C.; Alberdi M.B.; Gutiérrez-Rivas M.; Gómez-González C.; Galán-Vendrell I.; Rodríguez-Iglesias M.; Navarro-Marí J.M.; Corti D.; Rodríguez-Rodríguez G.; Bordes-Benítez A.; Bordoy A.E.; Moreno R.; Domínguez-Márquez V.; Bowen J.E.; Torres-Puente M.; de Chiara L.; Almela-Ferrer M.R.; Ruiz-Roldán L.; Garcia-Souto D.; Medina-Gonzalez R.; Catalán-Alonso P.; Fernández-Torres M.; Martínez-Priego L.; Torres I.; Coscollá M.; García-de-Viedma D.; Pablo-Marcos D.; Stadler T.; Aguirre-Quiñonero A.; Costa-Alcalde J.J.; Pequeno-Valtierra A.; Jiménez-Serrano S.; Coira A.; Navarro F.; Varela N.; Martró E.; Martínez M.J.; Gascón I.; Ocete M.D.; Herranz M.; Miró E.; Nadeau S.; de Salazar A.; Nogueira J.M.; Carvajal A.; Pérez-del-Molino M.L.; Gomez-Navarro I.; García-Basteiro A.L.; Marcos M.Á.; Walls A.C.; Hernáez-Crespo S.; Roig-Sena F.J.; de la Puente R.; De Marco G.; Rodriguez-Pallares S.; Benito R.; D’Auria G.; de Toro I.; Méndez-Legaza J.M.; Pastor-Boix E.; Goig G.A.; Chiner-Oms Á.; Alberola-Enguidanos J.; Mingorance J.; Parra-Grande M.; Neher R.A.; Pérez-Lago L.; Albert E.; Gracia-Grataloup Y.; Aguilera A.; Ferrús M.L.; Melon S.; Althaus C.L.; Tirado M.D.; Galán-Montemayor J.C.; Rojo-Alba S.; Chueca N.; Trastoy R.; López-Mirones J.I.; Gomez-Pinedo U.; Gonzalo-Jiménez N.; Chamizo-López F.; Azcona-Gutiérrez J.M.; Fregeneda-Grandes J.-M.; Ruiz-Rodríguez P.; Piñeiro L.; del Pozo J.L.; Vergara-Gómez A.; Tristancho-Baró A.; Marimón J.M.; Pérez-Tur J.; Fernandez-Cádenas I.; Ruiz-García M.M.; Aranzamendi-Zaldumbide M.; Reina J.; Antuori-Torres A.; Rodríguez-Lozano J.; Gómez-Camarasa C.; Simarro-Córdoba E.; Castelló-Abietar C.; Siller M.; Sorarrain A.; Navarro D.; Martínez-Cameo N.F.; Vaughan T.G.; González-Candelas F.; Pérez-González C.; Estévez-Gómez N.; Cilla G.; Mateo D.; Not A.; Bloom J.D.

doi:10.1038/s41586-021-03677-y

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000110815 037__ $$aART-2021-127168
000110815 041__ $$aeng
000110815 100__ $$aHodcroft E.B.
000110815 245__ $$aSpread of a SARS-CoV-2 variant through Europe in the summer of 2020.
000110815 260__ $$c2021
000110815 5060_ $$aAccess copy available to the general public$$fUnrestricted
000110815 5203_ $$aFollowing its emergence in late 2019, the spread of SARS-CoV-21,2 has been tracked by phylogenetic analysis of viral genome sequences in unprecedented detail3–5. Although the virus spread globally in early 2020 before borders closed, intercontinental travel has since been greatly reduced. However, travel within Europe resumed in the summer of 2020. Here we report on a SARS-CoV-2 variant, 20E (EU1), that was identified in Spain in early summer 2020 and subsequently spread across Europe. We find no evidence that this variant has increased transmissibility, but instead demonstrate how rising incidence in Spain, resumption of travel, and lack of effective screening and containment may explain the variant’s success. Despite travel restrictions, we estimate that 20E (EU1) was introduced hundreds of times to European countries by summertime travellers, which is likely to have undermined local efforts to minimize infection with SARS-CoV-2. Our results illustrate how a variant can rapidly become dominant even in the absence of a substantial transmission advantage in favourable epidemiological settings. Genomic surveillance is critical for understanding how travel can affect transmission of SARS-CoV-2, and thus for informing future containment strategies as travel resumes. © 2021, The Author(s), under exclusive licence to Springer Nature Limited.
000110815 536__ $$9info:eu-repo/grantAgreement/EC/H2020/101003688/EU/Epidemic intelligence to minimize 2019-nCoV’s public health, economic and social impact in Europe/EpiPose$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101003688-EpiPose$$9info:eu-repo/grantAgreement/EC/H2020/638553/EU/Integrating genomics, epidemiology and evolution to accelerate tuberculosis eradication/TB-ACCELERATE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 638553-TB-ACCELERATE
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