110815 20230519145558.0 doi 10.1038/s41586-021-03677-y sideral 127168 ART-2021-127168 eng Hodcroft E.B. Spread of a SARS-CoV-2 variant through Europe in the summer of 2020. 2021 Access copy available to the general public Unrestricted Following its emergence in late 2019, the spread of SARS-CoV-21,2 has been tracked by phylogenetic analysis of viral genome sequences in unprecedented detail3–5. Although the virus spread globally in early 2020 before borders closed, intercontinental travel has since been greatly reduced. However, travel within Europe resumed in the summer of 2020. Here we report on a SARS-CoV-2 variant, 20E (EU1), that was identified in Spain in early summer 2020 and subsequently spread across Europe. We find no evidence that this variant has increased transmissibility, but instead demonstrate how rising incidence in Spain, resumption of travel, and lack of effective screening and containment may explain the variant’s success. Despite travel restrictions, we estimate that 20E (EU1) was introduced hundreds of times to European countries by summertime travellers, which is likely to have undermined local efforts to minimize infection with SARS-CoV-2. Our results illustrate how a variant can rapidly become dominant even in the absence of a substantial transmission advantage in favourable epidemiological settings. Genomic surveillance is critical for understanding how travel can affect transmission of SARS-CoV-2, and thus for informing future containment strategies as travel resumes. © 2021, The Author(s), under exclusive licence to Springer Nature Limited. info:eu-repo/grantAgreement/EC/H2020/101003688/EU/Epidemic intelligence to minimize 2019-nCoV’s public health, economic and social impact in Europe/EpiPose This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101003688-EpiPose info:eu-repo/grantAgreement/EC/H2020/638553/EU/Integrating genomics, epidemiology and evolution to accelerate tuberculosis eradication/TB-ACCELERATE This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 638553-TB-ACCELERATE info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 69.504 2021 MULTIDISCIPLINARY SCIENCES 1 / 74 = 0.014 2021 Q1 T1 17.897 2021 Multidisciplinary 2021 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Zuber M. Nadeau S. Vaughan T.G. Crawford K.H.D. Althaus C.L. Reichmuth M.L. Bowen J.E. Walls A.C. Corti D. Bloom J.D. Veesler D. Mateo D. Hernando A. Comas I. González-Candelas F. González-Candelas F. Goig G.A. Chiner-Oms Á. Cancino-Muñoz I. López M.G. Torres-Puente M. Gomez-Navarro I. Jiménez-Serrano S. Ruiz-Roldán L. Bracho M.A. García-González N. Martínez-Priego L. Galán-Vendrell I. Ruiz-Hueso P. De Marco G. Ferrús M.L. Carbó-Ramírez S. D’Auria G. Coscollá M. Ruiz-Rodríguez P. Roig-Sena F.J. Sanmartín I. Garcia-Souto D. Pequeno-Valtierra A. Tubio J.M.C. Rodríguez-Castro J. Rabella N. Navarro F. Miró E. Rodríguez-Iglesias M. Galán-Sanchez F. Rodriguez-Pallares S. de Toro M. Escudero M.B. Azcona-Gutiérrez J.M. Alberdi M.B. Mayor A. García-Basteiro A.L. Moncunill G. Dobaño C. Cisteró P. García-de-Viedma D. Pérez-Lago L. Herranz M. Sicilia J. Catalán-Alonso P. Muñoz P. Muñoz-Cuevas C. Rodríguez-Rodríguez G. Alberola-Enguidanos J. Nogueira J.M. Camarena J.J. Rezusta A. Universidad de Zaragoza (orcid)0000-0001-7294-245X Tristancho-Baró A. Milagro A. Martínez-Cameo N.F. Gracia-Grataloup Y. Martró E. Bordoy A.E. Not A. Antuori-Torres A. Benito R. Universidad de Zaragoza (orcid)0000-0001-5134-1006 Algarate S. Universidad de Zaragoza (orcid)0000-0002-0036-6630 Bueno J. del Pozo J.L. Boga J.A. Castelló-Abietar C. Rojo-Alba S. Alvarez-Argüelles M.E. Melon S. Aranzamendi-Zaldumbide M. Vergara-Gómez A. Fernández-Pinero J. Martínez M.J. Vila J. Rubio E. Peiró-Mestres A. Navero-Castillejos J. Posada D. Valverde D. Estévez-Gómez N. Fernandez-Silva I. de Chiara L. Gallego-García P. Varela N. Moreno R. Tirado M.D. Gomez-Pinedo U. Gozalo-Margüello M. Eliecer-Cano M. Méndez-Legaza J.M. Rodríguez-Lozano J. Siller M. Pablo-Marcos D. Oliver A. Reina J. López-Causapé C. Canut-Blasco A. Hernáez-Crespo S. Cordón M.L.A. Lecároz-Agara M.-C. Gómez-González C. Aguirre-Quiñonero A. López-Mirones J.I. Fernández-Torres M. Almela-Ferrer M.R. Gonzalo-Jiménez N. Ruiz-García M.M. Galiana A. Sanchez-Almendro J. Cilla G. Montes M. Piñeiro L. Sorarrain A. Marimón J.M. Gomez-Ruiz M.D. López-Hontangas J.L. González Barberá E.M. Navarro-Marí J.M. Pedrosa-Corral I. Sanbonmatsu-Gámez S. Pérez-González C. Chamizo-López F. Bordes-Benítez A. Navarro D. Albert E. Torres I. Gascón I. Torregrosa-Hetland C.J. Pastor-Boix E. Cascales-Ramos P. Fuster-Escrivá B. Gimeno-Cardona C. Ocete M.D. Medina-Gonzalez R. González-Cantó J. Martínez-Macias O. Palop-Borrás B. de Toro I. Mediavilla-Gradolph M.C. Pérez-Ruiz M. González-Recio Ó. Gutiérrez-Rivas M. Simarro-Córdoba E. Lozano-Serra J. Robles-Fonseca L. de Salazar A. Viñuela-González L. Chueca N. García F. Gómez-Camarasa C. Carvajal A. de la Puente R. Martín-Sánchez V. Fregeneda-Grandes J.-M. Molina A.J. Argüello H. Fernández-Villa T. Farga-Martí M.A. Domínguez-Márquez V. Costa-Alcalde J.J. Trastoy R. Barbeito-Castiñeiras G. Coira A. Pérez-del-Molino M.L. Aguilera A. Planas A.M. Soriano A. Fernandez-Cádenas I. Pérez-Tur J. Marcos M.Á. Moreno-Docón A. Viedma E. Mingorance J. Galán-Montemayor J.C. Parra-Grande M. Stadler T. Neher R.A. 1011 630 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Microbiología 595 (2021), 707-712 Nature Nature 0028-0836 8401100 http://zaguan.unizar.es/record/110815/files/texto_completo.pdf Postprint 1158502 http://zaguan.unizar.es/record/110815/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:110815 articulos driver 2023-05-18-15:58:12 ARTICLE