Evolution of the use of corticosteroids for the treatment of hospitalised COVID-19 patients in Spain between March and November 2020: SEMI-COVID national registry

Balaz D.; Galvañ V.G.; Jansen-Chaparro S.; Alcalá J.N.; Perpiña B.O.; Samaniego N.T.; López R.B.; Corbella X.; Bailón M.M.; Casanova P.C.; Martínez L.F.C.; Huelgas R.G.; Montero A.; Morejón J.B.; Martínez M.L.T.; Villarreal G.; Klepzig J.L.G.; Tejido S.C.; Míguez A.M.; Amodeo Oblitas C.M.; Ramos J.C.; Iscar C.O.; Saavedra M.O.F.; Virto A.P.; Fernandez-Castelao S.; Fontan P.M.P.; Casado L.P.; Manglano J.D.; Lezaun C.G.; Purificación A.S.; Vergés C.D.; Pérez V.E.; Saldaña A.M.; Ortega L.O.; Fernández A.M.; Gómez J.A.; Galeano Valle F.; Gonzalo L.A.; Vieitez A.C.; Romero F.N.; Robles E.M.; Abanedes C.I.S.; López I.B.; Nohales C.M.; Wikman-Jorgensen P.E.; Casas-Rojo J.-M.; Troncoso J.Á.; Muñoz E.C.; Rubio-Rivas M.; Candalija A.C.; De Luque C.M.C.; Fernandez-Bravo I.G.; Bermúdez M.; Sanz M.T.M.; Beamonte E.D.C.; De Pedro I.P.; Bengoa G.D.; Cebrián M.B.; Caleya J.F.L.; Ayala-Gutiérrez M.M.; López-Carmona M.D.; Murgui R.M.; Castro S.M.; Ocaña P.G.; Mora-Luján J.M.; Mera I.F.; Benbunan C.C.; Christophel A.T.F.-T.; Martínez J.M.H.; Macías M.T.; Leoni M.E.G.; Godoy R.M.; Fonseca J.B.; López M.N.; Zapico A.M.; López C.M.O.; Guillan E.M.P.; Ledesma S.M.; Hernández C.D.; Fontán P.M.P.; Moreno M.C.; Muriel C.C.; Delgado C.M.; Campo B.M.; Cruz A.F.; Buonaiuto V.A.; López M.M.M.; García S.L.; Chamorro L.M.T.; Elías A.E.C.; Fernández M.S.; Etayo M.Z.; Jiménez-García N.; Pineda-Cantero A.; Martínez R.F.-M.; Suárez A.M.Á.; Corral-Gudino L.; Antúnez M.G.; Vidal A.D.; Aizpuru E.M.F.; Gómez C.R.; Iglesias M.F.G.; Molina S.C.; Rhyman N.; Ricci M.; Aseguinolaza M.G.; Sierra J.O.; Ayuso B.; Prieto M.M.; Simon R.D.; Escudero S.C.; Mendo C.L.; Guerrero M.B.; Cuchillo J.B.; Gurjian A.A.; De Oña Á.A.; Gómez A.E.; Garcia M.V.V.; Peláez E.P.; Vilan L.D.; Simón M.A.Q.; García García G.M.; Rivera N.A.; Núñez-Cortés J.M.; Gutiérrez J.C.M.; García A.T.; Lorenzo-Hernández E.; Romero M.A.F.; Fernández-Llamazares G.S.; Pedroche C.D.; Garcia A.; Palacios L.C.; Estrada A.D.B.; Ruiz D.P.; De Windt F.; García C.A.; Moreno A.D.C.; Del Pino J.L.; Clotet N.C.; Lahoz C.; Bandera V.A.; Cañas C.A.; De Santos S.; Montes J.T.; Fernández-Garcés M.; Blanco A.L.; Alegría J.G.; Do Rego A.T.; Hernández A.L.; Pérez S.C.; Sevilla J.J.M.; Jiménez P.D.; Ibáñez L.J.; Manau J.V.; Quintana F.B.; Muñoz J.A.; Escalante M.D.M.; Gil C.R.H.; Mayoral M.V.; Carrillo R.; Prieto J.M.M.; Mozo A.N.; Royo Trallero L.E.; De Blas P.A.; Sampalo A.L.; Pérez-Belmonte L.M.; Torre R.S.; Muñoz B.G.; Amezua C.H.; Grela A.G.; Narciso C.G.S.; Beato R.A.; Nuñez M.P.; Llorente B.P.; Carracedo E.F.; Fernández P.C.; Manuel E.C.; García J.G.; Rodríguez-Mancheño A.L.; Casas L.A.; Carmona J.M.; Hurtado Oliver J.A.; Ruiz S.P.; Andreu M.D.M.G.; Pampyn M.P.; Calvo C.M.; Fernández F.A.; Bueso T.S.; Gonzalo J.L.; Lora-Tamayo J.; Carrasco A.G.; Homs N.; Yeguas I.A.; Sánchez S.P.; Huerta L.J.; Corral J.B.; De La Calle G.M.; Cánovas J.S.; Hontañón V.; Frías M.C.; Ruperto L.R.; Hernández M.J.J.; Olleros C.L.; Jimeno V.M.; De La Chica M.N.; Carvajal M.C.C.; Arenzana C.B.; Abad M.D.C.B.; Sanz M.T.P.; Peralta E.E.D.; Capitán C.F.; Rodriguez V.N.; Quirantes P.L.; Reyne A.G.; Martínez D.L.; Bermejo C.L.; Tabares Y.U.; Veganzones L.I.; Jenaro M.M.F.-M.; Laorden C.J.

doi:10.3390/jcm10194610

000110828 001__ 110828
000110828 005__ 20230519145619.0
000110828 0247_ $$2doi$$a10.3390/jcm10194610
000110828 0248_ $$2sideral$$a127485
000110828 037__ $$aART-2021-127485
000110828 041__ $$aeng
000110828 100__ $$aBalaz D.
000110828 245__ $$aEvolution of the use of corticosteroids for the treatment of hospitalised COVID-19 patients in Spain between March and November 2020: SEMI-COVID national registry
000110828 260__ $$c2021
000110828 5060_ $$aAccess copy available to the general public$$fUnrestricted
000110828 5203_ $$aObjectives: Since the results of the RECOVERY trial, WHO recommendations about the use of corticosteroids (CTs) in COVID-19 have changed. The aim of the study is to analyse the evolutive use of CTs in Spain during the pandemic to assess the potential influence of new recommendations. Material and methods: A retrospective, descriptive, and observational study was conducted on adults hospitalised due to COVID-19 in Spain who were included in the SEMI-COVID- 19 Registry from March to November 2020. Results: CTs were used in 6053 (36.21%) of the included patients. The patients were older (mean (SD)) (69.6 (14.6) vs. 66.0 (16.8) years; p < 0.001), with hypertension (57.0% vs. 47.7%; p < 0.001), obesity (26.4% vs. 19.3%; p < 0.0001), and multimorbidity prevalence (20.6% vs. 16.1%; p < 0.001). These patients had higher values (mean (95% CI)) of C-reactive protein (CRP) (86 (32.7-160) vs. 49.3 (16-109) mg/dL; p < 0.001), ferritin (791 (393-1534) vs. 470 (236- 996) µg/dL; p < 0.001), D dimer (750 (430-1400) vs. 617 (345-1180) µg/dL; p < 0.001), and lower Sp02/Fi02 (266 (91.1) vs. 301 (101); p < 0.001). Since June 2020, there was an increment in the use of CTs (March vs. September; p < 0.001). Overall, 20% did not receive steroids, and 40% received less than 200 mg accumulated prednisone equivalent dose (APED). Severe patients are treated with higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%. Conclusions: Patients with greater comorbidity, severity, and inflammatory markers were those treated with CTs. In severe patients, there is a trend towards the use of higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%.
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000110828 591__ $$aMEDICINE, GENERAL & INTERNAL$$b55 / 172 = 0.32$$c2021$$dQ2$$eT1
000110828 593__ $$aMedicine (miscellaneous)$$c2021$$dQ1
000110828 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000110828 700__ $$aWikman-Jorgensen P.E.
000110828 700__ $$aGalvañ V.G.
000110828 700__ $$aRubio-Rivas M.
000110828 700__ $$aCampo B.M.
000110828 700__ $$aLópez M.N.
000110828 700__ $$aCaleya J.F.L.
000110828 700__ $$aHuelgas R.G.
000110828 700__ $$aFontán P.M.P.
000110828 700__ $$aBailón M.M.
000110828 700__ $$aFernández-Garcés M.
000110828 700__ $$aCruz A.F.
000110828 700__ $$aGarcía García G.M.
000110828 700__ $$aRhyman N.
000110828 700__ $$aCorral-Gudino L.
000110828 700__ $$aRodríguez-Mancheño A.L.
000110828 700__ $$aDe La Chica M.N.
000110828 700__ $$aGarcía A.T.
000110828 700__ $$aAlcalá J.N.
000110828 700__ $$aJiménez P.D.
000110828 700__ $$aRoyo Trallero L.E.$$uUniversidad de Zaragoza
000110828 700__ $$aCasanova P.C.
000110828 700__ $$aNúñez-Cortés J.M.
000110828 700__ $$aCasas-Rojo J.-M.
000110828 700__ $$aCorbella X.
000110828 700__ $$aHoms N.
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000110828 700__ $$aTejido S.C.
000110828 700__ $$aPedroche C.D.
000110828 700__ $$aSimon R.D.
000110828 700__ $$aReyne A.G.
000110828 700__ $$aVeganzones L.I.
000110828 700__ $$aHuerta L.J.
000110828 700__ $$aBlanco A.L.
000110828 700__ $$aGonzalo J.L.
000110828 700__ $$aLora-Tamayo J.
000110828 700__ $$aBermejo C.L.
000110828 700__ $$aDe La Calle G.M.
000110828 700__ $$aGodoy R.M.
000110828 700__ $$aPerpiña B.O.
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000110828 700__ $$aMontes J.T.
000110828 700__ $$aBandera V.A.
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000110828 700__ $$aRodriguez V.N.
000110828 700__ $$aSierra J.O.
000110828 700__ $$aCasas L.A.
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000110828 700__ $$aBeato R.A.
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000110828 700__ $$aCebrián M.B.
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000110828 700__ $$aGuerrero M.B.
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000110828 700__ $$aFernández P.C.
000110828 700__ $$aCarrillo R.
000110828 700__ $$aPérez S.C.
000110828 700__ $$aMuñoz E.C.
000110828 700__ $$aMoreno A.D.C.
000110828 700__ $$aCarvajal M.C.C.
000110828 700__ $$aDe Santos S.
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000110828 700__ $$aJenaro M.M.F.-M.
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000110828 700__ $$aFernandez-Bravo I.G.
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000110828 700__ $$aIbáñez L.J.
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000110828 700__ $$aVillarreal G.
000110828 700__ $$aEtayo M.Z.
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000110828 700__ $$aPeláez E.P.
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000110828 700__ $$aSimón M.A.Q.
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000110828 700__ $$aPurificación A.S.
000110828 700__ $$aBueso T.S.
000110828 700__ $$aTorre R.S.
000110828 700__ $$aAbanedes C.I.S.
000110828 700__ $$aTabares Y.U.
000110828 700__ $$aMayoral M.V.
000110828 700__ $$aManau J.V.
000110828 700__ $$aRivera N.A.
000110828 700__ $$aVieitez A.C.
000110828 700__ $$aBeamonte E.D.C.
000110828 700__ $$aManglano J.D.
000110828 700__ $$aMera I.F.
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000110828 700__ $$aNuñez M.P.
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000110828 700__ $$aKlepzig J.L.G.
000110828 700__ $$aBermúdez M.
000110828 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000110828 773__ $$g10, 19 (2021), 4610 [17 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
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000110828 951__ $$a2023-05-18-16:13:18
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