110828 20230519145619.0 doi 10.3390/jcm10194610 sideral 127485 ART-2021-127485 eng Balaz D. Evolution of the use of corticosteroids for the treatment of hospitalised COVID-19 patients in Spain between March and November 2020: SEMI-COVID national registry 2021 Access copy available to the general public Unrestricted Objectives: Since the results of the RECOVERY trial, WHO recommendations about the use of corticosteroids (CTs) in COVID-19 have changed. The aim of the study is to analyse the evolutive use of CTs in Spain during the pandemic to assess the potential influence of new recommendations. Material and methods: A retrospective, descriptive, and observational study was conducted on adults hospitalised due to COVID-19 in Spain who were included in the SEMI-COVID- 19 Registry from March to November 2020. Results: CTs were used in 6053 (36.21%) of the included patients. The patients were older (mean (SD)) (69.6 (14.6) vs. 66.0 (16.8) years; p < 0.001), with hypertension (57.0% vs. 47.7%; p < 0.001), obesity (26.4% vs. 19.3%; p < 0.0001), and multimorbidity prevalence (20.6% vs. 16.1%; p < 0.001). These patients had higher values (mean (95% CI)) of C-reactive protein (CRP) (86 (32.7-160) vs. 49.3 (16-109) mg/dL; p < 0.001), ferritin (791 (393-1534) vs. 470 (236- 996) µg/dL; p < 0.001), D dimer (750 (430-1400) vs. 617 (345-1180) µg/dL; p < 0.001), and lower Sp02/Fi02 (266 (91.1) vs. 301 (101); p < 0.001). Since June 2020, there was an increment in the use of CTs (March vs. September; p < 0.001). Overall, 20% did not receive steroids, and 40% received less than 200 mg accumulated prednisone equivalent dose (APED). Severe patients are treated with higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%. Conclusions: Patients with greater comorbidity, severity, and inflammatory markers were those treated with CTs. In severe patients, there is a trend towards the use of higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.964 2021 MEDICINE, GENERAL & INTERNAL 55 / 172 = 0.32 2021 Q2 T1 1.04 2021 Medicine (miscellaneous) 2021 Q1 4.4 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Wikman-Jorgensen P.E. Galvañ V.G. Rubio-Rivas M. Campo B.M. López M.N. Caleya J.F.L. Huelgas R.G. Fontán P.M.P. Bailón M.M. Fernández-Garcés M. Cruz A.F. García García G.M. Rhyman N. Corral-Gudino L. Rodríguez-Mancheño A.L. De La Chica M.N. García A.T. Alcalá J.N. Jiménez P.D. Royo Trallero L.E. Universidad de Zaragoza Casanova P.C. Núñez-Cortés J.M. Casas-Rojo J.-M. Corbella X. Homs N. Montero A. Mora-Luján J.M. De Blas P.A. Cañas C.A. Ayuso B. Morejón J.B. Escudero S.C. Frías M.C. Tejido S.C. Pedroche C.D. Simon R.D. Reyne A.G. Veganzones L.I. Huerta L.J. Blanco A.L. Gonzalo J.L. Lora-Tamayo J. Bermejo C.L. De La Calle G.M. Godoy R.M. Perpiña B.O. Ruiz D.P. Fernández M.S. Montes J.T. Bandera V.A. Alegría J.G. Jiménez-García N. Del Pino J.L. Escalante M.D.M. Romero F.N. Rodriguez V.N. Sierra J.O. Casas L.A. De Oña Á.A. Beato R.A. Gonzalo L.A. Muñoz J.A. Amodeo Oblitas C.M. García C.A. Cebrián M.B. Corral J.B. Guerrero M.B. Estrada A.D.B. Moreno M.C. Fernández P.C. Carrillo R. Pérez S.C. Muñoz E.C. Moreno A.D.C. Carvajal M.C.C. De Santos S. Gómez A.E. Carracedo E.F. Jenaro M.M.F.-M. Galeano Valle F. Garcia A. Fernandez-Bravo I.G. Leoni M.E.G. Antúnez M.G. Narciso C.G.S. Gurjian A.A. Ibáñez L.J. Olleros C.L. Mendo C.L. García S.L. Jimeno V.M. Nohales C.M. Ledesma S.M. Míguez A.M. Delgado C.M. Ortega L.O. Sánchez S.P. Virto A.P. Sanz M.T.P. Llorente B.P. Ruiz S.P. Fernández-Llamazares G.S. Macías M.T. Samaniego N.T. Do Rego A.T. Garcia M.V.V. Villarreal G. Etayo M.Z. Suárez A.M.Á. Vergés C.D. Martínez R.F.-M. Aizpuru E.M.F. Carrasco A.G. Amezua C.H. Martínez D.L. López M.M.M. Zapico A.M. Iscar C.O. Casado L.P. Martínez M.L.T. Chamorro L.M.T. Ayala-Gutiérrez M.M. López R.B. Fonseca J.B. Buonaiuto V.A. Martínez L.F.C. Palacios L.C. Muriel C.C. De Windt F. Christophel A.T.F.-T. Ocaña P.G. García J.G. Hurtado Oliver J.A. Jansen-Chaparro S. López-Carmona M.D. Quirantes P.L. Sampalo A.L. Lorenzo-Hernández E. Sevilla J.J.M. Carmona J.M. Pérez-Belmonte L.M. De Pedro I.P. Pineda-Cantero A. Gómez C.R. Ricci M. Cánovas J.S. Troncoso J.Á. Fernández F.A. Quintana F.B. Arenzana C.B. Molina S.C. Candalija A.C. Bengoa G.D. Grela A.G. Hernández A.L. Vidal A.D. Capitán C.F. Iglesias M.F.G. Muñoz B.G. Gil C.R.H. Martínez J.M.H. Hontañón V. Hernández M.J.J. Lahoz C. Calvo C.M. Gutiérrez J.C.M. Prieto M.M. Robles E.M. Saldaña A.M. Fernández A.M. Prieto J.M.M. Mozo A.N. López C.M.O. Peláez E.P. Pampyn M.P. Simón M.A.Q. Ramos J.C. Ruperto L.R. Purificación A.S. Bueso T.S. Torre R.S. Abanedes C.I.S. Tabares Y.U. Mayoral M.V. Manau J.V. Rivera N.A. Vieitez A.C. Beamonte E.D.C. Manglano J.D. Mera I.F. Andreu M.D.M.G. Aseguinolaza M.G. Lezaun C.G. Laorden C.J. Murgui R.M. Sanz M.T.M. Abad M.D.C.B. Romero M.A.F. Castro S.M. Guillan E.M.P. Nuñez M.P. Fontan P.M.P. Yeguas I.A. Gómez J.A. Cuchillo J.B. López I.B. Clotet N.C. Elías A.E.C. Manuel E.C. De Luque C.M.C. Benbunan C.C. Vilan L.D. Hernández C.D. Peralta E.E.D. Pérez V.E. Fernandez-Castelao S. Saavedra M.O.F. Klepzig J.L.G. Bermúdez M. 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 10, 19 (2021), 4610 [17 pp.] J. clin.med. Journal of Clinical Medicine 2077-0383 1020841 http://zaguan.unizar.es/record/110828/files/texto_completo.pdf Versión publicada 2815710 http://zaguan.unizar.es/record/110828/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:110828 articulos driver 2023-05-18-16:13:18 ARTICLE