000110832 001__ 110832
000110832 005__ 20230519145620.0
000110832 0247_ $$2doi$$a10.3390/jcm10194402
000110832 0248_ $$2sideral$$a127563
000110832 037__ $$aART-2021-127563
000110832 041__ $$aeng
000110832 100__ $$aGarcía, M. J.
000110832 245__ $$aImpact of biological agents on postsurgical complications in inflammatory bowel disease: A multicentre study of Geteccu
000110832 260__ $$c2021
000110832 5060_ $$aAccess copy available to the general public$$fUnrestricted
000110832 5203_ $$aBackground: The impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab. Aims: To evaluate the impact of biologics on the risk of PC. Methods: A retrospective study was performed in 37 centres. Patients treated with biologics within 12 weeks before surgery were considered “exposed”. The impact of the exposure on the risk of 30-day PC and the risk of infections was assessed by logistic regression and propensity score-matched analysis. Results: A total of 1535 surgeries were performed on 1370 patients. Of them, 711 surgeries were conducted in the exposed cohort (584 anti-TNF, 58 vedolizumab and 69 ustekinumab). In the multivariate analysis, male gender (OR: 1.5; 95% CI: 1.2–2.0), urgent surgery (OR: 1.6; 95% CI: 1.2–2.2), laparotomy approach (OR: 1.5; 95% CI: 1.1–1.9) and severe anaemia (OR: 1.8; 95% CI: 1.3–2.6) had higher risk of PC, while academic hospitals had significantly lower risk. Exposure to biologics (either anti-TNF, vedolizumab or ustekinumab) did not increase the risk of PC (OR: 1.2; 95% CI: 0.97–1.58), although it could be a risk factor for postoperative infections (OR 1.5; 95% CI: 1.03–2.27). Conclusions: Preoperative administration of biologics does not seem to be a risk factor for overall PC, although it may be so for postoperative infections.
000110832 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000110832 590__ $$a4.964$$b2021
000110832 592__ $$a1.04$$b2021
000110832 594__ $$a4.4$$b2021
000110832 591__ $$aMEDICINE, GENERAL & INTERNAL$$b55 / 172 = 0.32$$c2021$$dQ2$$eT1
000110832 593__ $$aMedicine (miscellaneous)$$c2021$$dQ1
000110832 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000110832 700__ $$aRivero, M.
000110832 700__ $$aMiranda-Bautista, J.
000110832 700__ $$aBastón-Rey, I.
000110832 700__ $$aMesonero, F.
000110832 700__ $$aLeo-Carnerero, E.
000110832 700__ $$0(orcid)0000-0001-6883-8940$$aCasas-Deza, D.
000110832 700__ $$aCagigas Fernández, C.
000110832 700__ $$aMartin-Cardona, A.
000110832 700__ $$aEl Hajra, I.
000110832 700__ $$aHernández-Aretxabaleta, N.
000110832 700__ $$aPérez-Martínez, I.
000110832 700__ $$aFuentes-Valenzuela, E.
000110832 700__ $$aJiménez, N.
000110832 700__ $$aRubin de Célix, C.
000110832 700__ $$aGutiérrez, A.
000110832 700__ $$aSuárez Ferrer, C.
000110832 700__ $$aHuguet, J. M.
000110832 700__ $$aFernández-Clotet, A.
000110832 700__ $$aGonzález-Vivó, M.
000110832 700__ $$aDel Val, B.
000110832 700__ $$aCastro-Poceiro, J.
000110832 700__ $$aMelcarne, L.
000110832 700__ $$aDueñas, C.
000110832 700__ $$aIzquierdo, M.
000110832 700__ $$aMonfort, D.
000110832 700__ $$aBouhmidi, A.
000110832 700__ $$aRamírez de la Piscina, P.
000110832 700__ $$aRomero, E.
000110832 700__ $$aMolina, G.
000110832 700__ $$aZorrilla, J.
000110832 700__ $$aCalvino-Suárez, C.
000110832 700__ $$aSánchez, E.
000110832 700__ $$aNúñez, A.
000110832 700__ $$aSierra, O.
000110832 700__ $$aCastro, B.
000110832 700__ $$aZabana, Y.
000110832 700__ $$aGonzález-Partida, I.
000110832 700__ $$aDe la Maza, S.
000110832 700__ $$aCastaño, A.
000110832 700__ $$aNájera-Muñoz, R.
000110832 700__ $$aSánchez-Guillén, L.
000110832 700__ $$aRiat Castro, M.
000110832 700__ $$aRueda, J. L.
000110832 700__ $$aBenítez, J. M.
000110832 700__ $$aDelgado-Guillena, P.
000110832 700__ $$aTardillo, C.
000110832 700__ $$aPeña, E.
000110832 700__ $$aFrago-Larramona, S.
000110832 700__ $$aRodríguez-Grau. M. C.
000110832 700__ $$aPlaza, R.
000110832 700__ $$aPérez-Galindo, P.
000110832 700__ $$aMartínez-Cadilla, J.
000110832 700__ $$aMenchén, L.
000110832 700__ $$aBarreiro-De Acosta, M.
000110832 700__ $$aSánchez-Aldehuelo, R.
000110832 700__ $$aDe la Cruz, M. D.
000110832 700__ $$aLamuela, L. J.
000110832 700__ $$aMarín, I.
000110832 700__ $$aNieto-García, L.
000110832 700__ $$aLópez San Román, A.
000110832 700__ $$aHerrera, J. M.
000110832 700__ $$aChaparro, M.
000110832 700__ $$aGisbert, J. P.
000110832 700__ $$aYoung Group of GETECCU
000110832 773__ $$g10, 19 (2021), 4402 [17 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000110832 8564_ $$s760640$$uhttps://zaguan.unizar.es/record/110832/files/texto_completo.pdf$$yVersión publicada
000110832 8564_ $$s3267739$$uhttps://zaguan.unizar.es/record/110832/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000110832 909CO $$ooai:zaguan.unizar.es:110832$$particulos$$pdriver
000110832 951__ $$a2023-05-18-16:14:29
000110832 980__ $$aARTICLE