000110868 001__ 110868
000110868 005__ 20240319080949.0
000110868 0247_ $$2doi$$a10.3390/diagnostics12020379
000110868 0248_ $$2sideral$$a127726
000110868 037__ $$aART-2022-127726
000110868 041__ $$aeng
000110868 100__ $$0(orcid)0000-0003-1234-9712$$aFernández-Espinosa, Guisela
000110868 245__ $$aRetinal Vascularization Abnormalities Studied by Optical Coherence Tomography Angiography (OCTA) in Type 2 Diabetic Patients with Moderate Diabetic Retinopathy
000110868 260__ $$c2022
000110868 5060_ $$aAccess copy available to the general public$$fUnrestricted
000110868 5203_ $$aDiabetic retinopathy (DR) is the most severe and frequent retinal vascular disease that causes significant visual loss on a global scale. The purpose of our study was to evaluate retinal vascularization in the superficial capillary plexus (SCP), the deep capillary plexus (DCP) and the choriocapillaris (CC) and changes in the foveal avascular zone (FAZ) by optical tomography angiography (OCTA) in patients with type 2 diabetes mellitus (DM2) with moderate DR but without diabetic macular oedema (DME). Fifty-four eyes of DM2 with moderate DR (level 43 in the ETDRS scale) and without DME and 73 age-matched healthy eyes were evaluated using OCTA with swept-source (SS)-OCT to measure microvascularization changes in SCP, DCP, CC and the FAZ. The mean ages were 64.06 ± 11.98 and 60.79 ± 8.62 years in the DM2 and control groups, respectively. Visual acuity (VA) was lower in the DM2 patients (p = 0.001), OCTA showed changes in the SCP with a significant diminution in the vascular density and the FAZ area was significantly higher compared to healthy controls, with p < 0.001 at the SCP level. The most prevalent anatomical alterations were peripheral disruption in the SCP (83.3%), microaneurysms (MA) in the SCP and in the DCP (79.6% and 79.6%, respectively) and flow changes in the DCP (81.5%). A significant positive correlation was observed between the DM2 duration and the FAZ area in the SCP (0.304 with p = 0.025). A significant negative correlation was also found between age and CC central perfusion (p < 0.001). In summary, a decrease in the vascular density in DM2 patients with moderate DR without DME was observed, especially at the retinal SPC level. Furthermore, it was found that the FAZ was increased in the DM2 group in both retinal plexuses and was greater in the SCP group.
000110868 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B08-20R$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00740
000110868 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000110868 590__ $$a3.6$$b2022
000110868 592__ $$a0.67$$b2022
000110868 591__ $$aMEDICINE, GENERAL & INTERNAL$$b64 / 169 = 0.379$$c2022$$dQ2$$eT2
000110868 593__ $$aClinical Biochemistry$$c2022$$dQ2
000110868 594__ $$a3.6$$b2022
000110868 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000110868 700__ $$aBoned-Murillo, Ana
000110868 700__ $$0(orcid)0000-0003-2710-1875$$aOrduna-Hospital, Elvira$$uUniversidad de Zaragoza
000110868 700__ $$aDíaz-Barreda, María Dolores
000110868 700__ $$0(orcid)0000-0002-5621-1937$$aSánchez-Cano, Ana$$uUniversidad de Zaragoza
000110868 700__ $$aBielsa-Alonso, Sofía
000110868 700__ $$0(orcid)0000-0002-2987-6351$$aAcha, Javier$$uUniversidad de Zaragoza
000110868 700__ $$0(orcid)0000-0003-0349-9997$$aPinilla, Isabel$$uUniversidad de Zaragoza
000110868 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000110868 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000110868 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000110868 773__ $$g12, 2 (2022), 379 [14 pp.]$$tDiagnostics$$x2075-4418
000110868 8564_ $$s5331849$$uhttps://zaguan.unizar.es/record/110868/files/texto_completo.pdf$$yVersión publicada
000110868 8564_ $$s2807123$$uhttps://zaguan.unizar.es/record/110868/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000110868 909CO $$ooai:zaguan.unizar.es:110868$$particulos$$pdriver
000110868 951__ $$a2024-03-18-12:51:56
000110868 980__ $$aARTICLE