000110874 001__ 110874
000110874 005__ 20230519145617.0
000110874 0247_ $$2doi$$a10.1038/s41598-021-00050-x
000110874 0248_ $$2sideral$$a127528
000110874 037__ $$aART-2021-127528
000110874 041__ $$aeng
000110874 100__ $$aCastaño-Bonilla, Tamara
000110874 245__ $$aPrognostic significance of FLT3-ITD length in AML patients treated with intensive regimens
000110874 260__ $$c2021
000110874 5060_ $$aAccess copy available to the general public$$fUnrestricted
000110874 5203_ $$aFLT3-ITD mutations are detected in approximately 25% of newly diagnosed adult acute myeloid leukemia (AML) patients and confer an adverse prognosis. The FLT3-ITD allelic ratio has clear prognostic value. Nevertheless, there are numerous manuscripts with contradictory results regarding the prognostic relevance of the length and insertion site (IS) of the FLT3-ITD fragment. We aimed to assess the prognostic impact of these variables on the complete remission (CR) rates, overall survival (OS) and relapse-free survival (RFS) of AML patients with FLT3-ITDmutations. We studied the FLT3-ITD length of 362 adult AML patients included in the PETHEMA AML registry. We tried to validate the thresholds of ITD length previously published (i.e., 39 bp and 70 bp) in intensively treated AML patients (n = 161). We also analyzed the mutational profile of 118 FLT3-ITD AML patients with an NGS panel of 39 genes and correlated mutational status with the length and IS of ITD. The AUC of the ROC curve of the ITD length for OS prediction was 0.504, and no differences were found when applying any of the thresholds for OS, RFS or CR rate. Only four out of 106 patients had ITD IS in the TKD1 domain. Our results, alongside previous publications, confirm that FLT3-ITD length lacks prognostic value and clinical applicability. © 2021, The Author(s).
000110874 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000110874 590__ $$a4.997$$b2021
000110874 592__ $$a1.005$$b2021
000110874 591__ $$aMULTIDISCIPLINARY SCIENCES$$b19 / 74 = 0.257$$c2021$$dQ2$$eT1
000110874 593__ $$aMultidisciplinary$$c2021$$dQ1
000110874 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000110874 700__ $$aAlonso-Dominguez, Juan M.
000110874 700__ $$aBarragán, Eva
000110874 700__ $$aRodríguez-Veiga, Rebeca
000110874 700__ $$aSargas, Claudia
000110874 700__ $$aGil, Cristina
000110874 700__ $$aChillón, Carmen
000110874 700__ $$aVidriales, María B.
000110874 700__ $$aGarcía, Raimundo
000110874 700__ $$aMartínez-López, Joaquín
000110874 700__ $$aAyala, Rosa
000110874 700__ $$aLarrayoz, María J.
000110874 700__ $$aAnguita, Eduardo
000110874 700__ $$aCuello, Rebeca
000110874 700__ $$aCantalapiedra, Alberto
000110874 700__ $$aCarrillo, Estrella
000110874 700__ $$aSoria-Saldise, Elena
000110874 700__ $$aLabrador, Jorge
000110874 700__ $$aRecio, Isabel
000110874 700__ $$aAlgarra, Lorenzo
000110874 700__ $$aRodríguez-Medina, Carlos
000110874 700__ $$aBilbao-Syeiro, Cristina
000110874 700__ $$aLópez-López, Juan A.
000110874 700__ $$aSerrano, Josefina
000110874 700__ $$aDe Cabo, Erik
000110874 700__ $$aSayas, María J.
000110874 700__ $$0(orcid)0000-0002-6326-5992$$aOlave, María T.$$uUniversidad de Zaragoza
000110874 700__ $$aSánchez-García, Joaquín
000110874 700__ $$aMateos, Mamen
000110874 700__ $$aBlas, Carlos
000110874 700__ $$aLópez-Lorenzo, Jose L.
000110874 700__ $$aLainez-Gonzalez, Daniel
000110874 700__ $$aSerrano, Juana
000110874 700__ $$aMartínez-Cuadrón, David
000110874 700__ $$aSanz, Miguel A.
000110874 700__ $$aMontesinos, Pau
000110874 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000110874 773__ $$g11 (2021), 20745 [10 pp]$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000110874 8564_ $$s3241274$$uhttps://zaguan.unizar.es/record/110874/files/texto_completo.pdf$$yVersión publicada
000110874 8564_ $$s2511413$$uhttps://zaguan.unizar.es/record/110874/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000110874 909CO $$ooai:zaguan.unizar.es:110874$$particulos$$pdriver
000110874 951__ $$a2023-05-18-16:11:40
000110874 980__ $$aARTICLE