000110877 001__ 110877 000110877 005__ 20230519145618.0 000110877 0247_ $$2doi$$a10.3389/fmed.2021.674997 000110877 0248_ $$2sideral$$a127540 000110877 037__ $$aART-2021-127540 000110877 041__ $$aeng 000110877 100__ $$aAlonso-Fernández, Alberto 000110877 245__ $$aInfluence of obstructive sleep apnea on systemic inflammation in pregnancy 000110877 260__ $$c2021 000110877 5060_ $$aAccess copy available to the general public$$fUnrestricted 000110877 5203_ $$aBackground: Obstructive sleep apnea (OSA) is prevalent in pregnancy and it is associated with adverse pregnancy-related outcomes such as gestational diabetes, pre-eclampsia, and low birth weight. Maternal systemic inflammation is proposed to be one of the main intermediate mechanisms. However, the effects of OSA on systemic inflammation are unknown in normal pregnancy. Methods: Women in the 3rd trimester underwent hospital polysomnography to evaluate whether OSA increases systemic inflammation in normal pregnancy and its potential association with adverse fetal outcomes. OSA was defined as an apnea–hypopnea index (AHI) of = 5 h-1. Plasma cytokines levels (TNF-a, IL-1ß, IL-6, IL-8, and IL-10) were determined by multiple immunoassays. Results: We included 11 patients with OSA and 22 women with AHI < 5 h-1, who were homogeneous in age, and body mass index (BMI). Women with OSA had significant higher levels of TNF-a, IL-1ß, IL-8, and IL-10. We found significant correlations between AHI during REM and TNF-a (r = 0.40), IL-1ß (r = 0.36), IL-6 (r = 0.52), IL-8 (r = 0.43), between obstructive apnea index and TNF-a (r = 0.46) and between AHI and IL-1ß (r = 0.43). We also found that CT90% was related to IL-8 (r = 0.37). There were no significant differences in neonatal characteristics; however, we found inverse correlations between TNF-a and IL-8 with birth weight (both r = -0.48), while IL-8 showed a significant inverse relationship with neonatal gestational age (r = -0.48). Conclusions: OSA in our normal pregnancy population was associated with higher systemic inflammation, which was related to obstructive events, especially during REM sleep. Moreover, systemic inflammation was inversely correlated with neonatal birth weight and age. 000110877 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/PI10/00495 000110877 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000110877 590__ $$a5.058$$b2021 000110877 592__ $$a1.179$$b2021 000110877 594__ $$a3.4$$b2021 000110877 591__ $$aMEDICINE, GENERAL & INTERNAL$$b53 / 172 = 0.308$$c2021$$dQ2$$eT1 000110877 593__ $$aMedicine (miscellaneous)$$c2021$$dQ1 000110877 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000110877 700__ $$aRibot Quetglas, Caterina 000110877 700__ $$aHerranz Mochales, Andrea 000110877 700__ $$aÁlvarez Ruiz De Larrinaga, Ainhoa 000110877 700__ $$aSánchez Barón, Andrés 000110877 700__ $$aRodríguez Rodríguez, Paula 000110877 700__ $$aGil Gómez, Ana Victoria 000110877 700__ $$aPía Martínez, Carla 000110877 700__ $$aCubero Marín, José Pablo 000110877 700__ $$aBarceló Nicolau, Maria 000110877 700__ $$aCerdà Moncadas, María 000110877 700__ $$aCodina Marcet, Mercedes 000110877 700__ $$aDe La Peña Bravo, Mónica 000110877 700__ $$aBarceló Bennasar, Antònia 000110877 700__ $$aIglesias Coma, Amanda 000110877 700__ $$aMorell-Garcia, Daniel 000110877 700__ $$aPeña Zarza, José Antonio 000110877 700__ $$aGiménez Carrero, María Paloma 000110877 700__ $$aDurán Cantolla, Joaquín 000110877 700__ $$0(orcid)0000-0001-9096-2294$$aMarín Trigo, José María$$uUniversidad de Zaragoza 000110877 700__ $$aPiñas Cebrian, María Concepción 000110877 700__ $$aSoriano, Joan B 000110877 700__ $$aGarcía-Río, Francisco 000110877 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000110877 773__ $$g8 (2021), 674997 [13 pp.]$$pFront. med.$$tFrontiers in Medicine$$x2296-858X 000110877 8564_ $$s970878$$uhttps://zaguan.unizar.es/record/110877/files/texto_completo.pdf$$yVersión publicada 000110877 8564_ $$s2541386$$uhttps://zaguan.unizar.es/record/110877/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000110877 909CO $$ooai:zaguan.unizar.es:110877$$particulos$$pdriver 000110877 951__ $$a2023-05-18-16:12:27 000110877 980__ $$aARTICLE