110877 20230519145618.0 doi 10.3389/fmed.2021.674997 sideral 127540 ART-2021-127540 eng Alonso-Fernández, Alberto Influence of obstructive sleep apnea on systemic inflammation in pregnancy 2021 Access copy available to the general public Unrestricted Background: Obstructive sleep apnea (OSA) is prevalent in pregnancy and it is associated with adverse pregnancy-related outcomes such as gestational diabetes, pre-eclampsia, and low birth weight. Maternal systemic inflammation is proposed to be one of the main intermediate mechanisms. However, the effects of OSA on systemic inflammation are unknown in normal pregnancy. Methods: Women in the 3rd trimester underwent hospital polysomnography to evaluate whether OSA increases systemic inflammation in normal pregnancy and its potential association with adverse fetal outcomes. OSA was defined as an apnea–hypopnea index (AHI) of = 5 h-1. Plasma cytokines levels (TNF-a, IL-1ß, IL-6, IL-8, and IL-10) were determined by multiple immunoassays. Results: We included 11 patients with OSA and 22 women with AHI < 5 h-1, who were homogeneous in age, and body mass index (BMI). Women with OSA had significant higher levels of TNF-a, IL-1ß, IL-8, and IL-10. We found significant correlations between AHI during REM and TNF-a (r = 0.40), IL-1ß (r = 0.36), IL-6 (r = 0.52), IL-8 (r = 0.43), between obstructive apnea index and TNF-a (r = 0.46) and between AHI and IL-1ß (r = 0.43). We also found that CT90% was related to IL-8 (r = 0.37). There were no significant differences in neonatal characteristics; however, we found inverse correlations between TNF-a and IL-8 with birth weight (both r = -0.48), while IL-8 showed a significant inverse relationship with neonatal gestational age (r = -0.48). Conclusions: OSA in our normal pregnancy population was associated with higher systemic inflammation, which was related to obstructive events, especially during REM sleep. Moreover, systemic inflammation was inversely correlated with neonatal birth weight and age. info:eu-repo/grantAgreement/ES/MINECO/PI10/00495 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.058 2021 MEDICINE, GENERAL & INTERNAL 53 / 172 = 0.308 2021 Q2 T1 1.179 2021 Medicine (miscellaneous) 2021 Q1 3.4 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Ribot Quetglas, Caterina Herranz Mochales, Andrea Álvarez Ruiz De Larrinaga, Ainhoa Sánchez Barón, Andrés Rodríguez Rodríguez, Paula Gil Gómez, Ana Victoria Pía Martínez, Carla Cubero Marín, José Pablo Barceló Nicolau, Maria Cerdà Moncadas, María Codina Marcet, Mercedes De La Peña Bravo, Mónica Barceló Bennasar, Antònia Iglesias Coma, Amanda Morell-Garcia, Daniel Peña Zarza, José Antonio Giménez Carrero, María Paloma Durán Cantolla, Joaquín Marín Trigo, José María Universidad de Zaragoza (orcid)0000-0001-9096-2294 Piñas Cebrian, María Concepción Soriano, Joan B García-Río, Francisco 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 8 (2021), 674997 [13 pp.] Front. med. Frontiers in Medicine 2296-858X 970878 http://zaguan.unizar.es/record/110877/files/texto_completo.pdf Versión publicada 2541386 http://zaguan.unizar.es/record/110877/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:110877 articulos driver 2023-05-18-16:12:27 ARTICLE