| TAZ-TFG-2020-915 |
Reproducibilidad de un nuevo sistema automático (CAPILLARY.IO) en el análisis de imágenes capilaroscópicas
Bas Alcolea, Paula
Gracia Tello, Borja del Carmelo (dir.)
Universidad de Zaragoza,
MED,
2020
Medicina, Psiquiatría y Dermatología department, Medicina area
Graduado en Medicina
Tipo de Trabajo Académico: Trabajo Fin de Grado
Notas: INTRODUCTION: Nailfold Capillaroscopy is a simple, inexpensive and non-invasive technique that allows microvascular damage to be observed, gaining recent importance in the diagnosis, monitoring and prognosis of many diseases with microangiopathy. However, the variability in the results interpretation has led to the development of new computerized systems that allow the automatic analysis of capillaroscopic images. OBJECTIVES: to compare the degree of agreement between the automatic system Capillary.io and a gold standard obtained from the agreement of 9 expert capillaroscopists and to know the degree of the interobserver reliability. To demonstrate the validity of the system to detect normal and enlarged capillaries, hemorrhages, megacapillaries, ramifications and tortuosities. METHODS: a cross-sectional study was performed in which 300 random and anonymous nailfold capillaroscopic images (1165 capillaries) were analyzed by 9 experienced observers. The degree of interobserver agreement was calculated from the 5 users. Likewise, the system performed an automatic assessment of the images and their agreement with the gold standard was calculated (interobserver agreement greater than 5, 6, 7, 8 and 9 successively). The validity of the program for each variable was also analyzed using sensitivity and specificity, positive and negative predictive values, and likelihood ratios, as well as their degree of agreement using the weighted kappa statistic (95% CI, p <0.05). The programs used for statistical calculations were SPSS 22.0 and EPIDAT 3.0. RESULTS: the degree of interobserver agreement was 76.5% for the agreement of 5 or more observers, progressively decreasing to 15.4% for the 9 observers. Capillary.io obtained higher levels of agreement, reaching 97.7% for the 9 observers. Statistically significant results were obtained in the automated detection of all the morphological alterations analyzed. CONCLUSIONS: Capillary.io demonstrated a high degree of agreement with the gold standard, stronger with greater consensus among observers. He was able to detect with great sensitivity and specificity hemorrhages and megacapillaries, very relevant alterations in microangiopathies. More studies will be necessary to analyze its functionality to detect dilatations, tortuosities and ramifications, although the results have been promising.
Notas: INTRODUCTION: Nailfold Capillaroscopy is a simple, inexpensive and non-invasive technique that allows microvascular damage to be observed, gaining recent importance in the diagnosis, monitoring and prognosis of many diseases with microangiopathy. However, the variability in the results interpretation has led to the development of new computerized systems that allow the automatic analysis of capillaroscopic images. OBJECTIVES: to compare the degree of agreement between the automatic system Capillary.io and a gold standard obtained from the agreement of 9 expert capillaroscopists and to know the degree of the interobserver reliability. To demonstrate the validity of the system to detect normal and enlarged capillaries, hemorrhages, megacapillaries, ramifications and tortuosities. METHODS: a cross-sectional study was performed in which 300 random and anonymous nailfold capillaroscopic images (1165 capillaries) were analyzed by 9 experienced observers. The degree of interobserver agreement was calculated from the 5 users. Likewise, the system performed an automatic assessment of the images and their agreement with the gold standard was calculated (interobserver agreement greater than 5, 6, 7, 8 and 9 successively). The validity of the program for each variable was also analyzed using sensitivity and specificity, positive and negative predictive values, and likelihood ratios, as well as their degree of agreement using the weighted kappa statistic (95% CI, p <0.05). The programs used for statistical calculations were SPSS 22.0 and EPIDAT 3.0. RESULTS: the degree of interobserver agreement was 76.5% for the agreement of 5 or more observers, progressively decreasing to 15.4% for the 9 observers. Capillary.io obtained higher levels of agreement, reaching 97.7% for the 9 observers. Statistically significant results were obtained in the automated detection of all the morphological alterations analyzed. CONCLUSIONS: Capillary.io demonstrated a high degree of agreement with the gold standard, stronger with greater consensus among observers. He was able to detect with great sensitivity and specificity hemorrhages and megacapillaries, very relevant alterations in microangiopathies. More studies will be necessary to analyze its functionality to detect dilatations, tortuosities and ramifications, although the results have been promising.
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trabajos-academicos-universidad-zaragoza > centro > facultad-de-medicina
trabajos-academicos-universidad-zaragoza > trabajos-fin-grado