000111648 001__ 111648
000111648 005__ 20230519145512.0
000111648 0247_ $$2doi$$a10.1038/s41398-021-01645-8
000111648 0248_ $$2sideral$$a126118
000111648 037__ $$aART-2021-126118
000111648 041__ $$aeng
000111648 100__ $$aGassó P.
000111648 245__ $$aA longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood
000111648 260__ $$c2021
000111648 5060_ $$aAccess copy available to the general public$$fUnrestricted
000111648 5203_ $$aLittle is known about the pathophysiological mechanisms of relapse in first-episode schizophrenia, which limits the study of potential biomarkers. To explore relapse mechanisms and identify potential biomarkers for relapse prediction, we analyzed gene expression in peripheral blood in a cohort of first-episode schizophrenia patients with less than 5 years of evolution who had been evaluated over a 3-year follow-up period. A total of 91 participants of the 2EPs project formed the sample for baseline gene expression analysis. Of these, 67 provided biological samples at follow-up (36 after 3 years and 31 at relapse). Gene expression was assessed using the Clariom S Human Array. Weighted gene co-expression network analysis was applied to identify modules of co-expressed genes and to analyze their preservation after 3 years of follow-up or at relapse. Among the 25 modules identified, one module was semi-conserved at relapse (DarkTurquoise) and was enriched with risk genes for schizophrenia, showing a dysregulation of the TCF4 gene network in the module. Two modules were semi-conserved both at relapse and after 3 years of follow-up (DarkRed and DarkGrey) and were found to be biologically associated with protein modification and protein location processes. Higher expression of DarkRed genes was associated with higher risk of suffering a relapse and early appearance of relapse (p = 0.045). Our findings suggest that a dysregulation of the TCF4 network could be an important step in the biological process that leads to relapse and suggest that genes related to the ubiquitin proteosome system could be potential biomarkers of relapse. © 2021, The Author(s).
000111648 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000111648 590__ $$a7.989$$b2021
000111648 592__ $$a2.076$$b2021
000111648 594__ $$a8.5$$b2021
000111648 591__ $$aPSYCHIATRY$$b24 / 157 = 0.153$$c2021$$dQ1$$eT1
000111648 593__ $$aCellular and Molecular Neuroscience$$c2021$$dQ1
000111648 593__ $$aBiological Psychiatry$$c2021$$dQ1
000111648 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000111648 700__ $$aRodríguez N.
000111648 700__ $$aMartínez-Pinteño A.
000111648 700__ $$aMezquida G.
000111648 700__ $$aRibeiro M.
000111648 700__ $$aGonzález-Peñas J.
000111648 700__ $$aZorrilla I.
000111648 700__ $$aMartínez-Sadurni L.
000111648 700__ $$aRodriguez-Jimenez R.
000111648 700__ $$aCorripio I.
000111648 700__ $$aSarró S.
000111648 700__ $$aIbáñez A.
000111648 700__ $$aUsall J.
000111648 700__ $$0(orcid)0000-0002-9098-655X$$aLobo Satué A.$$uUniversidad de Zaragoza
000111648 700__ $$aMoren C.
000111648 700__ $$aCuesta M.J.
000111648 700__ $$aParellada M.
000111648 700__ $$aGonzález-Pinto A.
000111648 700__ $$aBerrocoso E.
000111648 700__ $$aBernardo M.
000111648 700__ $$aMas S.
000111648 700__ $$aBioque M.
000111648 700__ $$aAmoretti S.
000111648 700__ $$aAndreu-Bernabeu A.
000111648 700__ $$aGurriarán X.
000111648 700__ $$aAlonso-Solís A.
000111648 700__ $$aGrasa E.
000111648 700__ $$aLópez P.
000111648 700__ $$aGarcia E.
000111648 700__ $$aBergé D.
000111648 700__ $$aTrabsa A.
000111648 700__ $$aSànchez-Pastor L.
000111648 700__ $$aJiménez-Rodríguez O.
000111648 700__ $$aPomarol-Clotet E.
000111648 700__ $$aFeria-Raposo I.
000111648 700__ $$aButjosa A.
000111648 700__ $$aPardo M.
000111648 700__ $$aMoreno-Izco L.
000111648 700__ $$aSánchez-Torres A.M.
000111648 700__ $$aSaiz-Ruiz J.
000111648 700__ $$aLeón-Quismondo L.
000111648 700__ $$aNacher J.
000111648 700__ $$aContreras F.
000111648 700__ $$aDe-la-Cámara C.
000111648 700__ $$aGutiérrez M.
000111648 700__ $$aSáiz P.A.
000111648 700__ $$a2EPs Group
000111648 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000111648 773__ $$g11 (2021), 539 [9 pp]$$pTransl Psychiatr$$tTranslational Psychiatry$$x2158-3188
000111648 8564_ $$s1949944$$uhttps://zaguan.unizar.es/record/111648/files/texto_completo.pdf$$yVersión publicada
000111648 8564_ $$s2888603$$uhttps://zaguan.unizar.es/record/111648/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000111648 909CO $$ooai:zaguan.unizar.es:111648$$particulos$$pdriver
000111648 951__ $$a2023-05-18-15:12:52
000111648 980__ $$aARTICLE