Incidence, clinical characteristics and management of inflammatory bowel disease in Spain: large-scale epidemiological study

Chaparro, M.; Monrobel, A.; Aguas, M.; Sicilia, B.; Martín-Arranz, M. D.; Marrero, J. M.; Rivero, M.; Bermejo, F.; Garre, A.; Zapata, E. M.; Duque, J. M.; Blázquez Gómez, I.; Casanova, M. J.; Bosch, O.; Gutiérrez, A.; Ber, Y.; Hernández, L.; Calafat, M.; Diz-Lois Palomares, M. T.; Marín-Jiménez, I.; Sierra, M.; Martínez Pascual, C.; Echarri, A.; Ortiz de Zarate, J.; Vicente, R.; Ginard, D.; Cruz, N.; Torra Alsina, S.; Hernández Camba, A.; Torrella Cortés, E.; Fernández-Salazar, L.; Gordillo, J.; Ferreiro-Iglesias, R.; Benítez, J. M.; López Serrano, P.; Roncero, Ó.; Alonso-Abreu, I.; Cabriada, J. L.; Barrio. J.; Bouhmidi, A.; Mata, L.; Rodríguez Mondéjar, S.; Nicolás, I.; Navarro-Llavat, M.; Montealegre, M.; Carmona, A.; Huguet, J. M.; Alonso-Galán, H.; Mir, A.; Vela, M.; Gómez-Valero, J. A.; Menacho, M.; Lorente Poyatos, R.; Martí Romero, L.; Alcalá, M. J.; Calvet, X.; Ledezma, C.; Ponferrada Díaz, Á.; García-Esquinas, E.; Gisbert, J. P.; Rodríguez, C.; Sabat, M.; Forcelledo, J. L. F.; Crespo Suarez, B.; Botella, B.; Herreros Martínez, B.; Sapiña, A.; Jiménez, N.; Ramírez Palanca, J. J.; Opio, V.; Irisarri, R.; Soler, M.; Muñoz Vicente, M.; Martínez-Cerezo, F. J.; Riestra, S.; Galve, M. L.; Vega, P.; Navarro, P.; Esteve Comas, M.; Robledo, P.; Barreiro de Acosta, M.; Hernández-Martínez, Á.; Novella Durán, M. T.; Castaño-Milla, C.; Lucendo, A. J.; Sesé Abizanda, E.; Kutz, M.; Fernández Salgado, E.; Varela Trastoy, P.; Hernández, V.; Kolle, L.; Torres Domínguez, Y.; Gomollón, F.; Sampedro, M. J.; Núñez Ortiz, A.; Maroto, N.; Spicakova, K.; Iyo E.; Nerín de la Puerta, J.; Fuentes Coronel, A. M.; Abraldes Bechiarelli, A.; Camargo, R.; Piñero, C.; Lluis, L.; Guerra del Río, E.; Rodríguez-Artalejo, F.; Hervías, D.; Fernández Rosáenz, H.; Tejada, M.; Vera-Mendoza, I.; Castro, E.; Sánchez Rodríguez, E.; Pozzati, L.

doi:10.3390/jcm10132885

000111680 001__ 111680
000111680 005__ 20230519145608.0
000111680 0247_ $$2doi$$a10.3390/jcm10132885
000111680 0248_ $$2sideral$$a127860
000111680 037__ $$aART-2021-127860
000111680 041__ $$aeng
000111680 100__ $$aChaparro, M.
000111680 245__ $$aIncidence, clinical characteristics and management of inflammatory bowel disease in Spain: large-scale epidemiological study
000111680 260__ $$c2021
000111680 5060_ $$aAccess copy available to the general public$$fUnrestricted
000111680 5203_ $$a(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD—Crohn’s disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)—during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100, 000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31–56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
000111680 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI16-01296$$9info:eu-repo/grantAgreement/ES/ISCIII/FI17-00143
000111680 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
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000111680 591__ $$aMEDICINE, GENERAL & INTERNAL$$b55 / 172 = 0.32$$c2021$$dQ2$$eT1
000111680 593__ $$aMedicine (miscellaneous)$$c2021$$dQ1
000111680 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000111680 700__ $$aGarre, A.
000111680 700__ $$aNúñez Ortiz, A.
000111680 700__ $$aDiz-Lois Palomares, M. T.
000111680 700__ $$aRodríguez, C.
000111680 700__ $$aRiestra, S.
000111680 700__ $$aVela, M.
000111680 700__ $$aBenítez, J. M.
000111680 700__ $$aFernández Salgado, E.
000111680 700__ $$aSánchez Rodríguez, E.
000111680 700__ $$aHernández, V.
000111680 700__ $$aFerreiro-Iglesias, R.
000111680 700__ $$aPonferrada Díaz, Á.
000111680 700__ $$aBarrio. J.
000111680 700__ $$aHuguet, J. M.
000111680 700__ $$aSicilia, B.
000111680 700__ $$aMartín-Arranz, M. D.
000111680 700__ $$aCalvet, X.
000111680 700__ $$aGinard, D.
000111680 700__ $$aAlonso-Abreu, I.
000111680 700__ $$aFernández-Salazar, L.
000111680 700__ $$aVarela Trastoy, P.
000111680 700__ $$aRivero, M.
000111680 700__ $$aVera-Mendoza, I.
000111680 700__ $$aVega, P.
000111680 700__ $$aNavarro, P.
000111680 700__ $$aSierra, M.
000111680 700__ $$aCabriada, J. L.
000111680 700__ $$aAguas, M.
000111680 700__ $$0(orcid)0000-0002-7605-3534$$aVicente, R.$$uUniversidad de Zaragoza
000111680 700__ $$aNavarro-Llavat, M.
000111680 700__ $$aEcharri, A.
000111680 700__ $$0(orcid)0000-0003-0076-3529$$aGomollón, F.$$uUniversidad de Zaragoza
000111680 700__ $$aGuerra del Río, E.
000111680 700__ $$aPiñero, C.
000111680 700__ $$aCasanova, M. J.
000111680 700__ $$aSpicakova, K.
000111680 700__ $$aOrtiz de Zarate, J.
000111680 700__ $$aTorrella Cortés, E.
000111680 700__ $$aGutiérrez, A.
000111680 700__ $$aAlonso-Galán, H.
000111680 700__ $$aHernández-Martínez, Á.
000111680 700__ $$aMarrero, J. M.
000111680 700__ $$aLorente Poyatos, R.
000111680 700__ $$aCalafat, M.
000111680 700__ $$aMartí Romero, L.
000111680 700__ $$aRobledo, P.
000111680 700__ $$aBosch, O.
000111680 700__ $$aJiménez, N.
000111680 700__ $$aEsteve Comas, M.
000111680 700__ $$aDuque, J. M.
000111680 700__ $$aFuentes Coronel, A. M.
000111680 700__ $$aSampedro, M. J.
000111680 700__ $$aSesé Abizanda, E.
000111680 700__ $$aHerreros Martínez, B.
000111680 700__ $$aPozzati, L.
000111680 700__ $$aFernández Rosáenz, H.
000111680 700__ $$aCrespo Suarez, B.
000111680 700__ $$aLópez Serrano, P.
000111680 700__ $$aLucendo, A. J.
000111680 700__ $$aMuñoz Vicente, M.
000111680 700__ $$aBermejo, F.
000111680 700__ $$aRamírez Palanca, J. J.
000111680 700__ $$aMenacho, M.
000111680 700__ $$aCarmona, A.
000111680 700__ $$aCamargo, R.
000111680 700__ $$aTorra Alsina, S.
000111680 700__ $$aMaroto, N.
000111680 700__ $$aNerín de la Puerta, J.
000111680 700__ $$aCastro, E.
000111680 700__ $$aMarín-Jiménez, I.
000111680 700__ $$aBotella, B.
000111680 700__ $$aSapiña, A.
000111680 700__ $$aCruz, N.
000111680 700__ $$aForcelledo, J. L. F.
000111680 700__ $$aBouhmidi, A.
000111680 700__ $$aCastaño-Milla, C.
000111680 700__ $$aOpio, V.
000111680 700__ $$aNicolás, I.
000111680 700__ $$aKutz, M.
000111680 700__ $$aAbraldes Bechiarelli, A.
000111680 700__ $$aGordillo, J.
000111680 700__ $$aBer, Y.
000111680 700__ $$aTorres Domínguez, Y.
000111680 700__ $$aNovella Durán, M. T.
000111680 700__ $$aRodríguez Mondéjar, S.
000111680 700__ $$aMartínez-Cerezo, F. J.
000111680 700__ $$aKolle, L.
000111680 700__ $$aSabat, M.
000111680 700__ $$aLedezma, C.
000111680 700__ $$aIyo E.
000111680 700__ $$aRoncero, Ó.
000111680 700__ $$aIrisarri, R.
000111680 700__ $$aLluis, L.
000111680 700__ $$aBlázquez Gómez, I.
000111680 700__ $$aZapata, E. M.
000111680 700__ $$aAlcalá, M. J.
000111680 700__ $$aMartínez Pascual, C.
000111680 700__ $$aMontealegre, M.
000111680 700__ $$aMata, L.
000111680 700__ $$aMonrobel, A.
000111680 700__ $$aHernández Camba, A.
000111680 700__ $$aHernández, L.
000111680 700__ $$aTejada, M.
000111680 700__ $$aMir, A.
000111680 700__ $$aGalve, M. L.
000111680 700__ $$aSoler, M.
000111680 700__ $$aHervías, D.
000111680 700__ $$aGómez-Valero, J. A.
000111680 700__ $$aBarreiro de Acosta, M.
000111680 700__ $$aRodríguez-Artalejo, F.
000111680 700__ $$aGarcía-Esquinas, E.
000111680 700__ $$aGisbert, J. P.
000111680 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000111680 773__ $$g10, 13 (2021), 2885 [19 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
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000111680 951__ $$a2023-05-18-16:06:25
000111680 980__ $$aARTICLE

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